IL-21 Selectively Augments Cytotoxic Potential of Antigen-Activated MAIT Cells [0.03%]
白细胞介素-21可选择性增强抗原活化的MAIT细胞的细胞毒性潜力
Laura E Wedlock,Rajesh Lamichhane,Meg C Webley et al.
Laura E Wedlock et al.
Mucosal-associated invariant T (MAIT) cells are unconventional cytotoxic T cells restricted by MHC class 1 related molecule, MR1. They are activated through their T cell receptor (TCR) by derivatives from microbial riboflavin synthesis or i...
Charting Bird Tregs [0.03%]
鸟类Tregs的表征研究进展
Lingling Wu,Jingxia Wu,Guoliang Cui
Lingling Wu
Regulatory T cells (Tregs) are fundamental to immune homeostasis, maintaining peripheral tolerance and preventing pathological autoimmunity across vertebrate species. The recent publication, "Beyond FoxP3: Identification of a Chicken Regula...
Manuel O Jakob,Patrycja M Forster,Christoph S N Klose
Manuel O Jakob
Innate lymphoid cells (ILCs) are innate immune cells populating many tissues early in ontogeny. ILCs and T cells share basic transcriptional programs, immune modules, and effector functions. This article focuses on ILC2s, a subset capable o...
Multi-Omics Analysis Reveals Sex-Specific Signatures for BCG Vaccine Efficacy [0.03%]
多组学分析揭示了BCG疫苗有效性的性别特异性特征
Qiuyao Zhan,Liang Zhou,Jianbo Fu et al.
Qiuyao Zhan et al.
Vaccines are a cornerstone of global public health, but their efficacy can vary significantly among individuals. Bacille Calmette-Guérin (BCG) vaccine against tuberculosis is one of the most used vaccines, and its efficacy is influenced by...
Meningococcal Serogroup Y Meningitis Reveals Inborn Factor B Deficiency [0.03%]
脑膜炎奈瑟氏菌群B型脑膜炎揭示了先天性因子B缺乏症
Camille Bougeard,Eléonore Eskander,Paula Vieira Martins et al.
Camille Bougeard et al.
Complement factor B (FB) deficiency is an extremely rare alternative pathway (AP) defect predisposing to invasive infections, with only three families reported to date. We investigated a 14-year-old girl who developed Neisseria meningitidis...
Cytomegalovirus-Based Viral Vectors Elicit Robust Systemic and Tissue-Resident Immune Response Against SARS-CoV-2 Antigens [0.03%]
巨细胞病毒载体针对新冠病毒抗原产生较强的全身性和组织驻留性免疫应答
Maja Cokarić Brdovčak,Jelena Materljan Franki,Marko Šustić et al.
Maja Cokarić Brdovčak et al.
Current COVID-19 vaccines face challenges such as waning immunity and limited mucosal protection. These limitations highlight the importance of developing next-generation vaccines that can induce strong tissue-specific and systemic immune r...
Isolation of Pure Stable Human Treg Cells Based on Expression of GPA33 [0.03%]
基于GPA33表达的人纯化稳定Treg细胞的分离
Florencia Morgana,Edith Slot,Derk Amsen
Florencia Morgana
Adoptive cell therapy (ACT) with regulatory T (Treg) cells offers potential for treating immune-mediated diseases. Ensuring the purity and stability of Treg cell products is critical for safe and effective therapies, particularly when targe...
UBL3 Participates in the Early Stages of CD83-Dependent CD4+ T Cell Selection [0.03%]
UBL3参与CD83依赖的CD4⁺T细胞选择早期过程
Huw Morgan,Haiyin Liu,Jose A Villadangos et al.
Huw Morgan et al.
CD83 is critical for CD4+ T cell selection. It regulates MHC II ubiquitination and turnover at the surface of thymic epithelial cells (TECs). The role of UBL3, a recently identified adaptor molecule for MHC II ubiquitination, is unknown in ...
A Novel Murine Model of Hemophagocytic Lymphohistiocytosis-Like Inflammation in ZNFX1 Deficiency [0.03%]
ZNFX1缺陷小鼠模型中的一种新型噬血细胞淋巴组织细胞增多症样炎症模型
Diana Tintor,Samantha Milanesi,Tommaso Marchetti et al.
Diana Tintor et al.
Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory syndrome characterized by persistent activation of lymphocytes and macrophages. Recently, deleterious autosomal recessive mutations in ZNFX1 were reported to predispose pedia...
Gene Regulatory Programs of NK Cells Show That NCAM1 (CD56) and KIRs Are Controlled by Genetically Polymorphic Distal Regulatory Elements [0.03%]
NK细胞的基因调控程序表明NCAM1(CD56)和KIR受遗传多态性远端调控元件控制
Mariam A Salem,Aditi Varkey,Matthew D Estrada et al.
Mariam A Salem et al.
Owing to their immunoprotective properties, natural killer (NK) cells are critical for the innate immune response to pathogens, as well as a new wave of cancer immunotherapy that harnesses natural cytotoxicity. We sought to study the geneti...