Audrey Kahn,Rosalie Kempkes,Valentino D&#x;Onofrio;yEFIS Equity & Diversity Working Group
Audrey Kahn
The Respiratory Epithelial Barrier as an Immunopharmacological Rheostat: From Homeostatic Sentinel to Therapeutic Target in Chronic Lung Disease [0.03%]
呼吸道上皮屏障作为免疫药理调节器：从稳态哨兵到慢性肺病治疗靶点
Feng-Xian Ni,Jie Hu,Hui-Hui Chen et al.
Feng-Xian Ni et al.
The respiratory epithelium is a dynamic immunopharmacological interface that transcends its traditional role as a passive barrier to become a central coordinator of pulmonary immunity. This review introduces and elaborates on the paradigm o...
Ly Phuong Vy Nguyen,Christelle Oblet,Alice Barbarin et al.
Ly Phuong Vy Nguyen et al.
Chimeric antigen receptor (CAR)-T-based strategies target the B-cell maturation antigen (BCMA) expressed on the surface of malignant plasma cells in patients with multiple myeloma (MM). Idecabtagene vicleucel (ide-cel), an anti-BCMA CAR-T t...
Andrea Cossarizza
Andrea Cossarizza
Inflammaging, defined as the persistent, low-grade sterile inflammation accompanying aging, represents a central driver of age-related pathology, including cardiovascular dysfunction, neurodegeneration, metabolic disorders, and frailty. Thi...
Caecal Epithelium-Derived Thymic Stromal Lymphopoietin is not Required for Protective Immunity Against Whipworm [0.03%]
盲肠上皮来源的胸腺基质淋巴细胞生成素不参与抵抗鞭虫感染的保护性免疫反应
Connor P Lynch,Seona Thompson,Erin-Claire Pallott et al.
Connor P Lynch et al.
Recent research examining classical type two alarmin TSLP has uncovered non-epithelial cellular sources of the cytokine in various murine challenges. Trichuris muris is a key model of type two immunity in the intestine, with expulsion being...
Altered TRPM3-Dependent Cytosolic and Mitochondrial Calcium Influx in Natural Killer Cells of Post-COVID-19 Condition Patients [0.03%]
新冠后状态患者的自然杀伤细胞中TRPM3依赖的胞浆和线粒体钙内流改变
Chandi Tabeth Magawa,Natalie Eaton-Fitch,Katsuhiko Muraki et al.
Chandi Tabeth Magawa et al.
According to the World Health Organization (WHO), approximately 6% of COVID-19 cases develop serious long-term sequelae referred to as post-COVID-19 condition (PCC). Immunological disturbances such as persistent activation of immune cells a...
Hematopoietic Antigen Presenting Cells Fine-Tune the Effector Phenotype of Intrathymic Unconventional αβ T Cells [0.03%]
造血抗原递呈细胞调节胸腺非常规αβ T 淋巴细胞的分化方向
Yi Wang,Trang T Lam,Sotaro Ochiai et al.
Yi Wang et al.
The development of unconventional αβ T cells, including invariant natural killer T (iNKT) and mucosal-associated invariant T (MAIT) cells, in the thymus is distinct from conventional T cells. Unconventional αβ T cells adopt a memory phe...
Sebastiaan M W R Hamers,Emmy J Buter,Richard B Pouw
Sebastiaan M W R Hamers
The complement system is a key component of innate immunity, modulating immunological processes to maintain proper homeostasis. However, dysregulation of the complement can lead to severe pathologies. Complement therapeutics strive to reduc...