Reprogramming Disulfide Reduction in Endoplasmic Reticulum Uncouples Immune Evasion of Pancreatic Cancer [0.03%]
胰腺癌中内质网二硫键重编程使免疫逃避与代谢适应脱钩
Zhongqiu Guo,Yuting Lu,Li Zhang et al.
Zhongqiu Guo et al.
The modulation of immune checkpoint activity exerts profound impacts on tumor immunotherapy. However, the interfere of mature immune checkpoints encounter efficacy challenges in solid tumors, which underlies a critical barrier in clinical t...
A Structurally Stabilized Lipopolymer Nanoplatform Targeting Pan-Tissue Antigen-Presenting Cells Enables Durable in situ mRNA Cancer Immunotherapy [0.03%]
一种结构稳定的脂质聚集体纳米平台，用于靶向泛组织抗原呈递细胞，可实现长效的原位mRNA癌症免疫治疗
Ling Zeng,Qian Shen,Lingyu Wei et al.
Ling Zeng et al.
Messenger RNA (mRNA) vaccines have transformed cancer immunotherapy, yet delayed immune activation, multi-dose requirements, and poor efficacy in immunosuppressive tumor microenvironments (TMEs) hinder current platforms. Here, a structurall...
Boosting Seawater Desalination by Ampere-Level Nitrate Electroreduction On Defect-Rich Ultrathin RuCu Alloy Nanostructures [0.03%]
利用富缺陷的钌铜超薄合金纳米结构进行安培级硝酸根电解促进海水淡化
Juan Wang,Liang Guo,Qingbo Wa et al.
Juan Wang et al.
Freshwater scarcity and nitrate pollution in water bodies are two growing environmental concerns. Developing green and sustainable techniques for simultaneous rapid freshwater production from seawater and efficient effluent treatment is cru...
Phase Boundary Enabled High Dielectric Tunability in Ba1 - xSrxTiO3 Thin Films and their Integration on Silicon [0.03%]
基于相界的高性能BST铁电薄膜及其在硅片上的集成研究
Garima Kaura,Sukriti Mantri,Fang Liu et al.
Garima Kaura et al.
Achieving ultra-high dielectric tunability with robust temperature and frequency stability poses a key challenge for next-generation microwave electronics and telecommunications devices. Likewise, the integration of such materials with sili...
In Situ Phosphoester Polymer Layer Locking Oxygen Migration in Ni-Rich Cathodes Under Ultra-High Voltage [0.03%]
原位磷酯聚合物层锁定富镍正极材料的高压氧气迁移问题
Yue Pan,Cong-Zheng Chai,Ya-Hui Wang et al.
Yue Pan et al.
Raising the cutoff voltage of nickel-rich layered cathodes is an effective strategy to increase the energy density of lithium batteries, yet it markedly aggravates structural degradation and gas evolution driven by lattice oxygen instabilit...
A Radial Modulus-Gradient Fiber for Chronic Recording and Decoding in Deep Brain [0.03%]
一种用于深度大脑长期记录和解码的径向模量梯度光纤
Liyuan Wang,Chengqiang Tang,Zhengqi Han et al.
Liyuan Wang et al.
Fiber electronics provide the most promising platform for the detection, modulation, and reconstruction of biosignals in the brain. However, preserving stable communication between fiber electronics and cellular-scale targets in the deep br...
Ag Nanocluster-Triggered Lattice Oxygen Activation in Amorphous Sulfide Matrices for Superior Oxygen Evolution [0.03%]
用于优异氧气进化的非晶硫化物基质中Ag纳米团簇触发的晶格氧活化
Lanfang Wang,Jiahe Zhao,Hui Zhang et al.
Lanfang Wang et al.
Polymetallic sulfides have emerged as promising electrocatalysts for the oxygen evolution reaction (OER) due to their exceptional compositional tunability and excellent catalytic activity. However, stability is a huge challenge for large-sc...
Design Strategies for Laser Additive Manufacturing of High-Performance Alloys With Uniform Mechanical Properties [0.03%]
具有均匀力学性能的高性能合金激光增材制造设计策略
Jingqi Zhang,Jinyu Zhang,Xipeng Tan
Jingqi Zhang
Additive manufacturing (AM), or 3D printing, enables the fabrication of metallic components layer by layer with enhanced design flexibility and efficiency. However, the layer-wise build fashion of AM, along with the associated high cooling ...
Biomimetic Symbiotic Engineering: Mycelial Bioceramics to Activate Energy Metabolism for Enhanced Osteogenesis [0.03%]
仿生共生工程：菌丝生物陶瓷活化能量代谢促进骨再生
Jiyi Huang,Shijie Cao,Wenping Ma et al.
Jiyi Huang et al.
The repair of bone defects remains a considerable challenge, primarily due to the lack of biomimetic hierarchical structures and the insufficient supply of bioenergy in implants. Inspired by the symbiotic structural relationship between myc...
Solvation Regulation of Flame-Retardant Bromine-Based Electrolyte Enables Stable Cycling Dual-Ion Battery [0.03%]
溶剂调节的阻燃溴系电解质实现双离子电池稳定循环
Yibo Zhao,Tingyi Wang,Jian Shang et al.
Yibo Zhao et al.
Dual-ion batteries (DIBs) have emerged as an attractive electrochemical energy storage technology owing to the distinctive advantages of cost-effectiveness, high operating voltage, and high power density. Nevertheless, conventional electrol...