Analysis of Nonconcurrent Controls in Adaptive Platform Trials: Separating Randomized and Nonrandomized Information [0.03%]
自适应平台试验中非同期控制分析：分离随机与非随机信息
Ian C Marschner,I Manjula Schou
Ian C Marschner
Adaptive platform trials allow treatments to be added or dropped during the study, meaning that the control arm may be active for longer than the experimental arms. This leads to nonconcurrent controls, which provide nonrandomized informati...
Health Care Provider Clustering Using Fusion Penalty in Quasi-Likelihood [0.03%]
基于拟似然融合罚项的医疗服务供应商聚类算法研究
Lili Liu,Kevin He,Di Wang et al.
Lili Liu et al.
There has been growing research interest in developing methodology to evaluate the health care providers' performance with respect to a patient outcome. Random and fixed effects models are traditionally used for such a purpose. We propose a...
MTML: An Efficient Multitrait Multilocus GWAS Method Based on the Cauchy Combination Test [0.03%]
基于Cauchy组合检验的高效多性状多位点GWAS方法(MTML)
Hongping Guo,Tong Li,Yao Shi et al.
Hongping Guo et al.
Genome-wide association study (GWAS) by measuring the joint effect of multiple loci on multiple traits, has recently attracted interest, due to the decreased costs of high-throughput genotyping and phenotyping technologies. Previous studies...
Factor-Analytic Variance-Covariance Structures for Prediction Into a Target Population of Environments [0.03%]
用于预测目标环境的因子分析协方差结构
Hans-Peter Piepho,Emlyn Williams
Hans-Peter Piepho
Finlay-Wilkinson regression is a popular method for modeling genotype-environment interaction in plant breeding and crop variety testing. When environment is a random factor, this model may be cast as a factor-analytic variance-covariance s...
Robust Regression Techniques for Multiple Method Comparison and Transformation [0.03%]
稳健回归技术的多重方法比较与变换研究
Florian Dufey
Florian Dufey
A generalization of Passing-Bablok regression is proposed for comparing multiple measurement methods simultaneously. Possible applications include assay migration studies or interlaboratory trials. When comparing only two methods, the metho...
A Marginalized Zero-Inflated Negative Binomial Model for Spatial Data: Modeling COVID-19 Deaths in Georgia [0.03%]
用于空间数据的边缘零膨胀负二项模型：佐治亚州COVID-19死亡率建模
Fedelis Mutiso,John L Pearce,Sara E Benjamin-Neelon et al.
Fedelis Mutiso et al.
Spatial count data with an abundance of zeros arise commonly in disease mapping studies. Typically, these data are analyzed using zero-inflated models, which comprise a mixture of a point mass at zero and an ordinary count distribution, suc...
Years of Life Lost to COVID-19 and Related Mortality Indicators: An Illustration in 30 Countries [0.03%]
COVID-19导致的预期寿命损失及相关的死亡率指标：对30个国家的说明性分析
Valentin Rousson,Isabella Locatelli
Valentin Rousson
The concept of (potential) years of life lost is a measure of premature mortality that can be used to compare the impacts of different specific causes of death. However, interpreting a given number of years of life lost at face value is mor...
A Shared-Frailty Spatial Scan Statistic Model for Time-to-Event Data [0.03%]
一种用于生存数据的空间扫描统计模型的共享脆弱性方法
Camille Frévent,Mohamed-Salem Ahmed,Sophie Dabo-Niang et al.
Camille Frévent et al.
Spatial scan statistics are well-known methods widely used to detect spatial clusters of events. Furthermore, several spatial scan statistics models have been applied to the spatial analysis of time-to-event data. However, these models do n...
Biostatistical Aspects of Whole Genome Sequencing Studies: Preprocessing and Quality Control [0.03%]
全基因组测序研究的生物统计学问题：预处理与质量控制
Raphael O Betschart,Cristian Riccio,Domingo Aguilera-Garcia et al.
Raphael O Betschart et al.
Rapid advances in high-throughput DNA sequencing technologies have enabled large-scale whole genome sequencing (WGS) studies. Before performing association analysis between phenotypes and genotypes, preprocessing and quality control (QC) of...
Aude Allemang-Trivalle,Annabel Maruani,Bruno Giraudeau
Aude Allemang-Trivalle
In the individual stepped-wedge randomized trial (ISW-RT), subjects are allocated to sequences, each sequence being defined by a control period followed by an experimental period. The total follow-up time is the same for all sequences, but ...