Correction to "Design and Interpretation of Human Sulfotransferase A1 Assays" [0.03%]
"关于“人类硫酸转移酶A1测定的设计与解读”的更正通知"
[This corrects the article on p. 481 in vol. 44, PMID: 26658224.].
Plasma Protein and Lipoprotein Binding of Cis- and Trans-Permethrin and Deltamethrin in Adult Humans and Rats [0.03%]
成人人类和大鼠血浆蛋白及脂蛋白结合率测定氯氟氰菊酯顺式、反式异构体及右旋苯醚菊酯的研究
Pankaj Sethi,James V Bruckner,Tanzir B Mortuza et al.
Pankaj Sethi et al.
The majority of residents of the United States, Canada, and Europe are exposed to pyrethroids, the most commonly used class of insecticides. Surprisingly little is known about key aspects of their pharmacokinetics, including their mode of t...
Arylacetamide Deacetylase Enzyme: Presence and Interindividual Variability in Human Lungs [0.03%]
人类肺部芳基乙酰胺脱乙酰酶的存在及其个体间差异
Morena Gabriele,Paola Puccini,Marco Lucchi et al.
Morena Gabriele et al.
Human arylacetamide deacetylase (AADAC) is a single microsomal serine esterase involved in the hydrolysis of many acetyl-containing drugs. To date, the presence and activity of the AADAC enzyme in human lungs has been scarcely examined. We ...
Mechanism of H2S Formation from the Metabolism of Anetholedithiolethione and Anetholedithiolone by Rat Liver Microsomes [0.03%]
大鼠肝微粒体代谢安息香二硫酮和安息香二亚砜生成H2S的机制研究
Martin Dulac,Citra Nagarathinam,Patrick Dansette et al.
Martin Dulac et al.
The drug anetholedithiolethione (ADT) and its analogs have been extensively used as H2S donors. However, the mechanism of H2S formation from ADT under biologic conditions remains almost completely unknown. This article shows that only small...
The Enhancement of Subcutaneous First-Pass Metabolism Causes Nonlinear Pharmacokinetics of TAK-448 after a Single Subcutaneous Administration to Rats [0.03%]
单次皮下给药后TAK-448呈现非线性药代动力学特征是由于其皮下首关代谢增强所致
Yuu Moriya,Akifumi Kogame,Yoshihiko Tagawa et al.
Yuu Moriya et al.
2-(N-acetyl-D-tyrosyl-trans-4-hydroxy-L-prolyl-L-asparaginyl-L-threonyl-L-phenylalanyl) hydrazinocarbonyl-L-leucyl-Nω-methyl-L-arginyl-L-tryptophanamide monoacetate (TAK-448, RVT-602), a kisspeptin analog, has been developed as a therapeut...
Structure-Guided In Vitro to In Vivo Pharmacokinetic Optimization of Propargyl-Linked Antifolates [0.03%]
基于结构的从体外到体内抗叶酸类药物动力学优化研究
M N Lombardo,N G-Dayanandan,S Keshipeddy et al.
M N Lombardo et al.
Pharmacokinetic/pharmacodynamic properties are strongly correlated with the in vivo efficacy of antibiotics. Propargyl-linked antifolates, a novel class of antibiotics, demonstrate potent antibacterial activity against both Gram-positive an...
Role of Molybdenum-Containing Enzymes in the Biotransformation of the Novel Ghrelin Receptor Inverse Agonist PF-5190457: A Reverse Translational Bed-to-Bench Approach [0.03%]
含钼酶在新型胃饥饿素受体反向激动剂PF-5190457生物转化中的作用：从床到实验台的逆向翻译研究
Sravani Adusumalli,Rohitash Jamwal,R Scott Obach et al.
Sravani Adusumalli et al.
(R)-2-(2-methylimidazo[2,1-b]thiazol-6-yl)-1-(2-(5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl)-2,7-diazaspiro[3.5]nonan-7-yl)ethan-1-one (PF-5190457) was identified as a potent and selective inverse agonist of the ghrelin receptor [...
Clinical Extrapolation of the Effects of Dolutegravir and Other HIV Integrase Inhibitors on Folate Transport Pathways [0.03%]
关于多替拉韦及其他人类免疫缺陷病毒整合酶抑制剂对叶酸转运途径的影响的临床推论研究
Maciej J Zamek-Gliszczynski,Xuexiang Zhang,Jennypher Mudunuru et al.
Maciej J Zamek-Gliszczynski et al.
Preliminary analysis of ongoing birth surveillance study identified evidence of potential increased risk for neural tube defects (NTDs) in newborns associated with exposure to dolutegravir at the time of conception. Folate deficiency is a c...
Altered Expression and Function of Hepatic Transporters in a Rodent Model of Polycystic Kidney Disease [0.03%]
多囊肾病rodent模型中肝转运体的表达和功能改变
Jacqueline Bezençon,James J Beaudoin,Katsuaki Ito et al.
Jacqueline Bezençon et al.
Autosomal dominant polycystic kidney disease (ADPKD) is a common form of inherited polycystic kidney disease (PKD) and is a leading cause of kidney failure. Fluid-filled cysts develop in the kidneys of patients with ADPKD, and cysts often f...