Overestimation of the drug-drug interaction risk between remimazolam and clopidogrel [0.03%]
瑞美扎宗与氯吡格雷药物相互作用风险过高的问题
Hisakazu Ohtani,Mao Inagaki
Hisakazu Ohtani
Deoxynivalenol binds and impairs nuclear receptor pregnane X receptor function perturbing modulatory control over xenobiotic metabolism and disposition machinery [0.03%]
脱氧雪腐镰刀菌烯醇结合并损害核受体孕烷X受体功能，扰乱对异生物质代谢和转运装置的调节控制作用
Sheeba Rizvi,Priyanka Shandilya,Keshav Thakur et al.
Sheeba Rizvi et al.
Mycotoxins are prominent environmental pollutants that pose serious health risks. Deoxynivalenol (DON), a trichothecene mycotoxin, is a widespread food contaminant known to cause metabolic and hepatotoxic effects in humans and animals. Alth...
Aryl hydrocarbon receptor ligand 6-formylindolo[3,2-b]carbazole attenuates pressure overload cardiac hypertrophy by activating the CYP1A1/19(S)-hydroxyeicosatetraenoic acid (HETE) and suppressing midchain-HETEs/G protein coupled receptor 31 pathways [0.03%]
核受体aryl hydrocarbon receptor配体6-甲醛吲哚[3,2-b]咔唑通过激活CYP1A1/19(S)-羟基二十碳四烯酸并抑制中链长度的HETEs/G蛋白偶联受体31信号通路来减轻压力超负荷诱导的心脏肥大
Ahmad H Alammari,Shereen M Hamza,Fadumo Ahmed Isse et al.
Ahmad H Alammari et al.
Pressure overload induced cardiac hypertrophy is a major contributor to heart failure, and the arachidonic acid (AA) metabolism through cytochrome P450 enzymes is one of the metabolic pathways implicated in the hypertrophic response. The ar...
Metabolism and excretion pathways of CD388, a novel drug-fragment crystallizable conjugate for prevention of seasonal or pandemic influenza [0.03%]
新型药物CD388(Fc结合片段)预防季节性和大流行性流感的代谢和排泄途径研究
Jan Snoeys,Grayson Hough,Shawn Flanagan et al.
Jan Snoeys et al.
CD388 is an investigational antiviral drug-fragment crystallizable (Fc) conjugate comprising multiple copies of neuraminidase inhibitor stably conjugated to an Fc fragment of recombinant human IgG1 through a polyethylene glycol based linker...
Comparative effectiveness of 7 major human let-7-5p isoforms to modulate target gene expression in liver cells [0.03%]
7种主要的人let-7-5p异构体在肝细胞中调控靶基因表达的效果比较
Joseph M Cronin,Mei-Juan Tu,Yimei Wang et al.
Joseph M Cronin et al.
Dysregulation of efflux ATP-binding cassette (ABC) transporters often confers multidrug resistance, presenting significant challenges in treating various diseases (eg, hepatocellular carcinoma [HCC]). The let-7-5p microRNAs (miRNAs), common...
A semimechanistic PK/PD model-informed Taxus tablets' development: Accelerating early clinical translation of a taxane-based antitumor agent [0.03%]
基于半机制PK / PD模型的紫杉醇 tablet 开发：加速紫杉醇类抗肿瘤药物的临床转化
Yagang Li,Tianyang Jiang,Guanwen Mo et al.
Yagang Li et al.
Taxus chinensis formulation is clinically utilized for the treatment of cancer, while Taxus tablet is expected to be developed as an antitumor drug for early clinical trials. Preclinical pharmacokinetic/pharmacodynamics (PK/PD) analysis cou...
Drug-drug interactions induced by immunosuppressants through inhibition of human carboxylesterases [0.03%]
人类羧酸酯酶抑制引起的免疫抑制剂药物相互作用
Yuxin Yang,Jiahong Liang,Chenyuan Liao et al.
Yuxin Yang et al.
Immunosuppressants are a class of therapeutic agents that attenuate immune responses by modulating pathways involved in immune cell activation, proliferation, and signaling, and are widely used to prevent organ transplant rejection and to t...
Enzyme-substrate-inactivator complex formation can impact time-dependent inhibition kinetics [0.03%]
底物与酶和抑制剂形成的复合物会影响时间依赖性抑制动力学
Jaydeep Yadav,Jan Wahlstrom,Ken Korzekwa et al.
Jaydeep Yadav et al.
In order to predict drug-drug interactions (DDIs), screening and evaluating time-dependent inhibition (TDI) of cytochrome P450 is an important part of the drug discovery process. In vitro experiments are performed for obtaining TDI paramete...
Drug-drug interaction assessments of clinical transporter inhibition: Learnings from the Transporter Working Group of the International Consortium for Innovation and Quality in Pharmaceutical Development [0.03%]
药物相互作用评估中的临床转运体抑制作用：国际医药开发创新与质量联盟转运体工作组的研究成果
Rucha S Sane,Pallabi Mitra,Yurong Lai et al.
Rucha S Sane et al.
The International Consortium for Innovation and Quality for Pharmaceutical Development Transporter Working Group analyzed survey results submitted by 17 member companies describing in vitro and in vivo data for drug-drug interactions (DDI) ...
Yifan Gong,Carlos A Barrero,Magda L Florez et al.
Yifan Gong et al.
Concentrations of basic drugs are often overpredicted by physiologically based pharmacokinetic models at very early time points after intravenous dosing. An empirical shallow compartment in our recently published permeability- and perfusion...