Population pharmacokinetic analysis of onradivir to support dosing recommendations in elderly adults with influenza [0.03%]
奥拉地韦的群体药代动力学分析支持老年流感患者的给药方案
Xiao-Jie Zheng,Jiong-Xian Lv,Yi-Huan Huang et al.
Xiao-Jie Zheng et al.
Onradivir (ZSP1273) is a novel oral inhibitor of the influenza A virus polymerase PB2 subunit, developed for the treatment of influenza. Given that elderly patients represent a key target population and may experience age-related changes in...
Altered renal disposition of adefovir in metabolic dysfunction-associated steatohepatitis using the fast-food diet and thioacetamide-induced model to extrapolate renal secretion [0.03%]
快速食物饮食和硫代乙酰胺诱导的代谢紊乱相关肝脂肪性肝炎模型对肾分泌的外推研究中的阿德福韦肾排泄改变
Dominique O Farrera,Paxton A Sample,Mina M Alaaldin et al.
Dominique O Farrera et al.
Metabolic dysfunction-associated fatty liver disease and metabolic dysfunction-associated steatohepatitis (MASH) are the most prevalent liver diseases globally. As MASH progresses, changes in expression of xenobiotic transporters significan...
Characterization of human intestinal organoid-derived monolayers under air-liquid interface culture for pharmacokinetics evaluation [0.03%]
人肠道类器官衍生单层细胞的特征化及其在空气-液体界面培养中用于药代动力学评价
Ilona Wehl,Kazuyoshi Michiba,Veronika Walser et al.
Ilona Wehl et al.
Intestinal organoid-derived monolayers have emerged as a novel in vitro model for investigating drug absorption and metabolism. Air-liquid interface (ALI) culture method enhances physiologically relevance of epithelial cells. In this study,...
Rapid assessment of metabolism and disposition of conjugated oligonucleotide vutrisiran in rats using a sensitive LC-HRMS platform [0.03%]
一种敏感的LC-HRMS平台快速评估寡核苷酸偶联物vutrisiran在大鼠中的代谢和分布
Peng Li,Xianqing Yu,Jiamin Wu et al.
Peng Li et al.
Vutrisiran is an N-acetylgalactosamine (GalNAc)-conjugated small interfering RNA therapeutic approved for targeted hepatic delivery and long-acting gene silencing; however, detailed in vitro and in vivo metabolism data have not been publish...
Metabolomics-based predictive biomarker discovery for thiopurine response in Crohn disease: Plasma histidine as a promising biomarker [0.03%]
基于代谢组学的硫嘌呤类药物在克罗恩病治疗中反应预测生物标志物的发现：血浆组氨酸作为潜在生物标志物的识别
Sum-Yuet Chan,Kang Chao,Ting Yang et al.
Sum-Yuet Chan et al.
Thiopurine drugs are cornerstone immunosuppressive agents for treating Crohn disease (CD), yet their clinical utility is limited by significant interindividual variability in efficacy and a lack of reliable predictive biomarkers. This study...
Peptide-mediated delivery of an α-synuclein-targeting antisense oligonucleotide: Pharmacokinetics, safety, and central nervous system efficacy in a synucleinopathy model [0.03%]
基于肽的α-突触核蛋白靶向反义寡核苷酸输送：药代动力学，安全性及在突触核蛋白病模型中的中枢神经系统有效性
Rijwan U Ahammad,Bao Quach,Sahar Salehi et al.
Rijwan U Ahammad et al.
Effective blood-brain barrier penetration is a major challenge for antisense oligonucleotide (ASO) therapies targeting neurodegenerative diseases. We utilized an 11-amino acid peptide derived from apolipoprotein B (ApoB11) that binds the lo...
Clinical discovery of anti-CYP2E1 autoantibodies and preclinical efficacy of a CYP2E1 inhibitor in rheumatoid arthritis [0.03%]
类风湿关节炎的抗CYP2E1自身抗体的临床发现及CYP2E1抑制剂的药效学研究
Liyuan Gao,Hongming Yang,Mengyan Deng et al.
Liyuan Gao et al.
Rheumatoid arthritis (RA) is an autoimmune disease characterized by aberrant and persistent immune responses against self-antigens. However, the mechanisms of autoantibody production and the specific self-antigens in RA are not fully unders...
Reduction in estimated glomerular filtration rate observed with doravirine is caused by inhibition of organic cation transporter 2 [0.03%]
多拉韦林导致肾小球滤过率估计值下降是通过抑制有机阳离子转运蛋白2所致
Yang Li,Chitra Saran,Xiaoyan Chu et al.
Yang Li et al.
Doravirine (DOR), a potent nonnucleoside reverse transcriptase inhibitor for HIV-1 treatment, is primarily metabolized by cytochrome P450 3A enzymes to form doravirine carboxylic acid metabolite (M9), the major plasma metabolite excreted in...
Impact of SLCO1B1 and ABCB1 variants on statin efficacy and toxicity in a Tunisian population [0.03%]
SLCO1B1和ABCB1基因多态性对突尼斯人群他汀类药物疗效和毒性的影響
Houwaida Abbes,Yassine Khalij,Maha Meksi et al.
Houwaida Abbes et al.
Statins are the cornerstone treatment for coronary artery disease treatment. However, they exhibit considerable interindividual variability in both pharmacokinetics and pharmacodynamics. This variability was assessed by investigating 9 gene...
Erratum to "A semimechanistic PK/PD model-informed Taxus tablets' development: Accelerating early clinical translation of a taxane-based antitumor agent" [Drug Metabolism and Disposition 54 (2026) 100262] [0.03%]
“基于半机制PK/PD模型的紫杉醇片剂开发：加速紫杉烷类抗肿瘤药物临床转化”一文的勘误通知
Yagang Li,Tianyang Jiang,Guanwen Mo et al.
Yagang Li et al.