The Simultaneous Inhibition of Solute Carrier Family 6 Member 19 and Breast Cancer Resistance Protein Transporters Leads to an Increase of Indoxyl Sulfate (a Uremic Toxin) in Plasma and Kidney [0.03%]
Solute Carrier家族6成员19和乳腺癌耐药蛋白转运体的协同抑制导致血浆及肾脏中尿毒症毒素吲哚硫酸盐蓄积
Qingping Wang,Bogdan Munteanu,Alexander Marker et al.
Qingping Wang et al.
Solute carrier family 6 member 19 (SLC6A19) inhibitors are being studied as therapeutic agents for phenylketonuria. In this work, a potent SLC6A19 inhibitor (RA836) elevated rat kidney uremic toxin indoxyl sulfate (IDS) levels by intensity ...
Effects of Compound Probiotics on Pharmacokinetics of Cytochrome 450 Probe Drugs in Rats [0.03%]
复方益生菌对大鼠细胞色素P450探针药物药动学的影响
Yanjuan Zhang,Zhi Chen,Yayi Xiao et al.
Yanjuan Zhang et al.
Compound probiotics have been widely used and commonly coadministered with other drugs for treating various chronic illnesses, yet their effects on drug pharmacokinetics remain underexplored. This study elucidated the impact of VSL#3 on the...
CYP8B1 Catalyzes 12alpha-Hydroxylation of C27 Bile Acid: In Vitro Conversion of Dihydroxycoprostanic Acid into Trihydroxycoprostanic Acid [0.03%]
CYP8B1催化C27胆酸的12α-羟基化：将二羟基胆通酸转化为三羟基胆通酸的体内转化反应
Yutong Wang,Yixuan Wang,YiTing Hu et al.
Yutong Wang et al.
Sterol 12α-hydroxylase (CYP8B1) is the unique P450 enzyme with sterol 12-oxidation activity, playing an exclusive role in 12α-hydroxylating intermediates along the bile acid (BA) synthesis pathway. Despite the long history of BA metabolis...
The Induction of Drug Uptake Transporter Organic Anion Transporting Polypeptide 1A2 by Radiation Is Mediated by the Nonreceptor Tyrosine Kinase v-YES-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 [0.03%]
辐射诱导的药物摄取转运蛋白阴离子转运多肽1A2的表达由非受体酪氨酸激酶_yes_同源基因调节
Zicong Wu,Jiajian Yuan,Kui Li et al.
Zicong Wu et al.
Organic anion transporting polypeptides (OATP, gene symbol SLCO) are well-recognized key determinants for the absorption, distribution, and excretion of a wide spectrum of endogenous and exogenous compounds including many antineoplastic age...
Sarinj Fattah,Abhijit Babaji Shinde,Myriam Baes et al.
Sarinj Fattah et al.
The organic cation transporter (OCT)-1 mediates hepatic uptake of cationic endogenous compounds and xenobiotics. To date, limited information exists on how Oct1/OCT1 functionally develops with age in rat and human livers and how this would ...
Molecular Mechanisms for the Selective Transport of Dichlorofluorescein by Human Organic Anion Transporting Polypeptide 1B1 [0.03%]
人类阴离子转运多肽1B1选择性转运二氯荧光素的分子机制研究
Han Liu,Lanjing Li,Ting Liang et al.
Han Liu et al.
Human organic anion transporting polypeptide (OATP) 1B1 and 1B3 are two highly homologous liver-specific uptake transporters. However, 2',7'-dichlorofluorescein (DCF) is preferably transported by OATP1B1. In the present study, the molecular...
Characterization and Prediction of Organic Anion Transporting Polypeptide 1B Activity in Prostate Cancer Patients on Abiraterone Acetate Using Endogenous Biomarker Coproporphyrin I [0.03%]
使用内源性生物标志物粪卟啉原I表征和预测阿比特龙治疗的前列腺癌患者有机阴离子转运多肽1B活性
Ziteng Wang,Kylie Hoi Yan Luk,Eleanor Jing Yi Cheong et al.
Ziteng Wang et al.
Organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 are important hepatic transporters. We previously identified OATP1B3 being critically implicated in the disposition of abiraterone. We aimed to further investigate the effects of...
Investigations into the Concentrations and Metabolite Profiles of Doping Agents and Antidepressants in Human Seminal Fluid Using Liquid Chromatography-Mass Spectrometry [0.03%]
液相色谱-质谱法研究兴奋剂和抗抑郁药物在人精液中的浓度和代谢产物分布
Johanna Breuer,Ann-Marie Garzinsky,Andreas Thomas et al.
Johanna Breuer et al.
Exogenous substances, including drugs and chemicals, can transfer into human seminal fluid and influence male fertility and reproduction. In addition, substances relevant in the context of sports drug testing programs, can be transferred in...
Correlations of Long Noncoding RNA HNF4A-AS1 Alternative Transcripts with Liver Diseases and Drug Metabolism [0.03%]
长链非编码RNA HNF4A-AS1的可变剪切本与肝脏疾病和药物代谢的相关性研究
Jing Jin,Le Tra Giang Nguyen,Andrew Wassef et al.
Jing Jin et al.
Hepatocyte nuclear factor 4 alpha antisense 1 (HNF4A-AS1) is a long noncoding RNA (lncRNA) gene physically located next to the transcription factor HNF4A gene in the human genome. Its transcription products have been reported to inhibit the...
Nonclinical Pharmacokinetics Study of OLX702A-075-16, N-Acetylgalactosamine Conjugated Asymmetric Small Interfering RNA (GalNAc-asiRNA) [0.03%]
N-乙酰半乳糖胺不对称小干扰RNA（GalNAc-asiRNA）的非临床药代动力学研究
Jihye Ban,Bong Kyo Seo,Yunmi Yu et al.
Jihye Ban et al.
In this study, the nonclinical pharmacokinetics of OLX702A-075-16, an RNA interference therapeutic currently in development, were investigated. OLX702A-075-16 is a novel N-acetylgalactosamine conjugated asymmetric small-interfering RNA (Gal...