Centella asiatica Water Extract Shows Low Potential for Cytochrome P450-Mediated Drug Interactions [0.03%]
.centella asiatica 水提物几乎不对药物代谢酶cyp p450产生影响
Kirsten M Wright,Armando Alcazar Magana,Ronald M Laethem et al.
Kirsten M Wright et al.
Centella asiatica (CA) shows considerable promise for development as a botanical drug for cognitive decline. Its primary bioactive components include triterpene glycosides asiaticoside and madecassoside and their corresponding aglycones asi...
Abemaciclib Does Not Have a Clinically Meaningful Effect on Pharmacokinetics of CYP1A2, CYP2C9, CYP2D6, and CYP3A4 Substrates in Patients with Cancer [0.03%]
阿贝西利对癌症患者CYP1A2、CYP2C9、CYP2D6和CYP3A4底物药代动力学没有临床显著影响
P Kellie Turner,Stephen D Hall,Sonya C Chapman et al.
P Kellie Turner et al.
Abemaciclib is an orally administered, potent inhibitor of cyclin-dependent kinases 4 and 6 and is metabolized extensively by CYP3A4. The effects of abemaciclib on several CYPs were qualified in vitro and subsequently evaluated in a clinica...
Influence of Zuojin Pill on the Metabolism of Venlafaxine in Vitro and in Rats and Associated Herb-Drug Interaction [0.03%]
佐金丸对文拉法辛代谢的体内外影响及相应中药西药相互作用研究
Yue Li,Juan Li,Dongmin Yan et al.
Yue Li et al.
Venlafaxine (VEN), a first-line antidepressant, and Zuojin Pill (ZJP), a common Chinese herbal medicine consisting of Rhizoma Coptidis and Fructus Evodiae, have a high likelihood of combination usage in patients with depression with gastroi...
Dexamethasone-Induced Liver Enlargement Is Related to PXR/YAP Activation and Lipid Accumulation but Not Hepatocyte Proliferation [0.03%]
糖皮质激素致肝肿大与PXR/YAP活化和脂质蓄积相关但并非肝细胞增殖所致
Tingying Jiao,Xinpeng Yao,Yingyuan Zhao et al.
Tingying Jiao et al.
Dexamethasone (Dex), a widely prescribed anti-inflammatory drug, was reported to induce liver enlargement (hepatomegaly) in clinical practice and in animal models. However, the underlying mechanisms are not elucidated. Dex is a known activa...
Application of Azamulin to Determine the Contribution of CYP3A4/5 to Drug Metabolic Clearance Using Human Hepatocytes [0.03%]
用人肝细胞研究阿扎木林测定CYP3A4/5对药物代谢清除贡献的方法学应用
Hugues Chanteux,Maria Rosa,Claude Delatour et al.
Hugues Chanteux et al.
Early determination of CYP3A4/5 contribution to the clearance of new chemical entities is critical to inform on the risk of drug-drug interactions with CYP3A inhibitors and inducers. Several in vitro approaches (recombinant P450 enzymes, co...
Circadian Clock Component Rev-erb α Regulates Diurnal Rhythm of UDP-Glucuronosyltransferase 1a9 and Drug Glucuronidation in Mice [0.03%]
核受体调节素（Rev-erbα）调控小鼠尿苷二磷酸葡萄糖醛酸转移酶1a9的昼夜节律和药物葡萄糖醛酸化反应
Haiman Xu,Min Chen,Fangjun Yu et al.
Haiman Xu et al.
UDP-glucuronosyltransferases (UGTs) are a family of phase II enzymes that play an important role in metabolism and elimination of numerous endo- and xenobiotics. Here, we aimed to characterize diurnal rhythm of Ugt1a9 in mouse liver and to ...
Evaluation of Erythromycin as a Tool to Assess CYP3A Contribution of Low Clearance Compounds in a Long-Term Hepatocyte Culture [0.03%]
评价红霉素作为评估长期肝细胞培养中低清除率化合物CYP3A贡献的工具的效果
Tom S Chan,Young-Sun Scaringella,Klairynne Raymond et al.
Tom S Chan et al.
Long-term hepatocyte culture systems such as HepatoPac are well suited to evaluate the metabolic turnover of low clearance (CL) drugs because of their sustained metabolic capacity and longer-term viability. Erythromycin (ERY), a moderate, m...
The Impact of Infection and Inflammation on Drug Metabolism, Active Transport, and Systemic Drug Concentrations in Veterinary Species [0.03%]
感染和炎症对兽医物种药物代谢、主动转运和全身药物浓度的影响
Marilyn N Martinez,Jonathan Greene,Leslie Kenna et al.
Marilyn N Martinez et al.
Within human medicine, it is recognized that the pharmacokinetics (PK) of many compounds can be altered by the presence of inflammation or infection. Research into the reason for these changes has identified pathways that can influence drug...
Nrf2 Antioxidative System is Involved in Cytochrome P450 Gene Expression and Activity: A Delay in Pentobarbital Metabolism in Nrf2-Deficient Mice [0.03%]
NRF2抗氧系统参与细胞色素P450基因表达及活性：NRF2缺陷小鼠中 pentobarbital代谢延迟
Takashi Ashino,Masayuki Yamamoto,Satoshi Numazawa
Takashi Ashino
NF-E2-related factor 2 (Nrf2) is a transcriptional regulator of biologic defense proteins, such as antioxidant proteins and phase II detoxification enzymes. Cytochrome P450 (P450) enzymes have been shown to regulate phase I metabolism of va...
Excretion, Mass Balance, and Metabolism of [14C]LY3202626 in Humans: An Interplay of Microbial Reduction, Reabsorption, and Aldehyde Oxidase Oxidation That Leads to an Extended Excretion Profile [0.03%]
[14C]LY3202626在人体内的排泄、质量平衡及其代谢：微生物还原作用、重吸收以及醛氧化酶氧化相互作用导致的延长排泄模式
Kishore Katyayan,Ping Yi,Scott Monk et al.
Kishore Katyayan et al.
The mass balance, excretion, and metabolism of LY3202626 were determined in healthy subjects after oral administration of a single dose of 10 mg of (approximately 100 μCi) [14C]LY3202626. Excretion of radioactivity was slow and incomplete,...