Genistein from Thai Fermented Soybean (Thua-nao) Attenuates Osteoarthritis Pathogenesis via Dual Inhibition of NF-κB and MAPK Signaling: Evidence from Ex Vivo, Computational, and In Vitro Models [0.03%]
来源于泰国发酵大豆(Thua-nao)的Genistein通过NF-κB和MAPK信号的双途径抑制作用缓解骨关节炎病理：来自外源，计算和体外模型的证据
Benjawan Wudtiwai,Aitthiphon Chongchai,Pattaralawan Sittiju et al.
Benjawan Wudtiwai et al.
Aglycone isoflavones derived from fermented soybeans demonstrate antioxidant, anticancer, antiobesity, and anti-inflammatory properties, with evidence suggesting protective effects against cartilage deterioration. However, precise mechanism...
Carbene-Mediated Kinetic Resolution Reveals (1 S,2 R,4 R)-Cinmethylin as the Herbicidal Eutomer [0.03%]
卡宾介导的动力学拆分揭示了(1S,2R,4R)-cinmethylin是增效异构体
Jiahui Yao,Xingjie Zhang,Ziming Wang et al.
Jiahui Yao et al.
Global spread of weeds resistant to conventional herbicide modes of action threatens sustainable weed management. Cinmethylin, a decades-old herbicide with a unique molecular basis, has re-emerged for controlling resistant grass weeds, but ...
Gas Conduction Functional Units (GCFUs) Enable Quantitative Equilibrium Modified Atmosphere Packaging to Suppress Respiration and Pectin Degradation in Strawberries [0.03%]
气体传导功能单元(GCFU)使定量平衡气调包装能够抑制草莓的呼吸和果胶降解
Wenzhen Liao,Lingling Liu,Ying Zhang et al.
Wenzhen Liao et al.
Postharvest strawberry softening is driven by rapid pectin depolymerization, a process accelerated by the fruit's inherently high respiration rate. Although equilibrium modified atmosphere packaging (EMAP) can suppress respiration, conventi...
An Enzyme-Mediated Strategy for Diminishing Bitterness-Contributing Peptides of Pea (Pisum sativum) Protein Isolates [0.03%]
一种降低豌豆蛋白苦味多肽的酶法策略
Shengnan Wang,Chengliang Qi,Yueming Wang et al.
Shengnan Wang et al.
To improve the applicability of pea protein isolate (PPI), this work demonstrated that enzymatic hydrolysis effectively mitigates its bitterness, which is primarily driven by specific bitter peptides. Five peptides were validated with low r...
Construction of a Highly Efficient System for Fisetin-3-O-Glucoside Synthesis Using a Novel Glycosyltransferase AaUGT from Arabis alpina [0.03%]
利用报春苣苔新型糖基转移酶AaUGT构建高效合成白杨素-3-O-葡萄糖苷体系
Shiping Cao,Jiafeng Li,Kaixuan Ke et al.
Shiping Cao et al.
Fisetin is a natural polyhydroxyl flavonoid with anti-inflammatory, antioxidant, and neuroprotective activities, but its application in foods and agriculture is limited by poor stability, low absorption, and low bioavailability. Glycosylati...
Functional Divergence of Three Segmentally Duplicated UGT71 Enzymes Reveals Distinct Glycosylation Strategies toward Resveratrol and Emodin in Polygonum cuspidatum [0.03%]
三个片段重复的UGT71酶的功能分化揭示了雷公藤多苷片中白藜芦醇和大黄素的不同糖基化策略
Jianhui Chen,Hongping Ma,Fan Lin et al.
Jianhui Chen et al.
Polygonum cuspidatum is a medicinal and edible plant rich in bioactive phenolics, predominantly occurring as O-glycosides catalyzed by UDP-glycosyltransferases (UGTs). However, how gene duplication drives the UGT functional diversification ...
Dietary Lactic Acid Attenuates Ovalbumin-Induced Food Allergy in Mice via Orchestrating Dendritic Cell and T Cell Immune Tolerance [0.03%]
膳食乳酸通过调节树突状细胞和T细胞免疫耐受抑制小鼠卵清蛋白诱导的食品过敏反应
Ruofan Xie,Fan Yang,Yong Wu et al.
Ruofan Xie et al.
Food allergies have become a global public health problem, but effective interventions are limited. Lactic acid (LA), a major bioactive compound in fermented foods, possesses immunomodulatory potential, but its role in food allergies is poo...
Pathogen-Associated Molecular Pattern (PAMP)-Induced Peptide LcPIP1 Derived from Litchi Promotes the Resistance of Litchi Fruit against Litchi Downy Blight Caused by Peronophythora litchii [0.03%]
由中国荔枝果实疫病菌诱导的植物肽LcPIP1增强荔枝对果实疫病的抗性
Xiaoyun Ye,Shuwei Zhang,Yuean Wang et al.
Xiaoyun Ye et al.
Litchi downy blight is a postharvest disease caused by Peronophythora litchii, causing yield loss and postharvest deterioration. The role of native plant peptides in fruit responses to fungal infections has seldom been reported. Here, we id...
Galacto-Oligosaccharides Reshape Mucin O-Glycan Profiles to Enhance Small Intestinal Barrier Development in Early Life [0.03%]
益生元半乳低聚糖通过重塑黏蛋白O-聚糖谱型促进生命早期小肠屏障发育的作用机制研究
Laipeng Xu,Xuan Li,Wenlu Fan et al.
Laipeng Xu et al.
The mucin barrier is essential for postnatal gut homeostasis, but whether galacto-oligosaccharides (GOS) regulate mucin glycosylation remains unclear. Here, we investigated the effects of early-life GOS supplementation on mucin O-glycans an...
Unraveling the Multilevel Phytotoxicity of Micro(nano)plastics and Their Combined Effects with Antibiotics in Soil-Plant Systems: Internalization, Mechanisms, and ARG Dissemination [0.03%]
微纳米塑料及其与抗生素联合暴露对土植系统的多水平次生毒性效应：内化机制及 ARG 传播风险
Hua Wei,Shuiping Cheng
Hua Wei
Micro(nano)plastics (MNPs) often coexist with antibiotics in soil ecosystems via organic fertilizer applications. They can be taken up and accumulated by plants, especially food crops, thereby threatening food safety. Despite increasing glo...