Innovative Utilization of Bamboo for High-Yield Vitexin Production: Strategies and Optimization [0.03%]
竹资源高效生产黄耆苷的策略与优化研究
Ling Guo,Xin Yan,Wenli Xia et al.
Ling Guo et al.
Bamboo sugars such as glucose and cellobiose can be transformed into valuable biochemicals. Cellobiose, a glycosyl precursor, enables the synthesis of C-glycosyl flavonoids, such as vitexin, a bioactive compound in bamboo extracts. This stu...
Methyltransferase "Gating Loop" Reengineering: Reshaping Catalytic Performance through Tunnel Dynamics and Structural Flexibility [0.03%]
甲基转移酶“门控环”重工程：通过隧道动力学和结构柔韧性重塑催化性能
Ming-Xin Sun,Cui Zhang,Zhi-Han Gong et al.
Ming-Xin Sun et al.
The double mutant MsE of the methyltransferase EgtD from Mycobacterium smegmatis can catalyze the N-terminal trimethylation of L-tryptophan to produce the medicinal indole alkaloid L-hypaphorine. Structural comparison, loop deletion, and al...
Rational Engineering of a GH18 Chitinase for Enhanced Thermostability and Catalytic Efficiency via Dynamic Allosteric Modulation [0.03%]
通过动态别构调节理性工程改造GH18型几丁质酶以增强其热稳定性和催化效率
Xingyue Wang,Jianrong Chen,Liyan Yang et al.
Xingyue Wang et al.
Engineering chitinases with simultaneous improvements in catalytic efficiency and thermostability remains challenging. Here, we present a computational strategy targeting the insertion domain (CID), a noncatalytic auxiliary region. Using Ca...
Discovery of a Unique NRPS Gene Cluster San for the Biosynthesis of Anti-Phytopathogenic and Cytotoxic Sansalvamides in the Endophytic Fusarium sp. R1 [0.03%]
一株内生轮枝菌中沉默抗植物病原和细胞毒性的独特非核糖体肽合成酶基因簇Sansalvamide的生物合成研究
Yuanyuan Liu,Jiaoqun Liao,Wangjie Zhu et al.
Yuanyuan Liu et al.
Sansalvamides are a class of bioactive cyclodepsipeptides recognized for their potent antitumor properties. In this study, genome mining of an endophytic fungus Fusarium sp. R1 led to the identification of a unique nonribosomal peptide synt...
GcPG and GcGel: Verification of Their Key Roles in Geotrichum citri-aurantii Infecting Citrus via Overexpression and Effects on Fruit Membrane Lipid [0.03%]
Geotrichum 柑橘致病菌中GcPG和GcGel的关键作用及其对果实膜脂的影响
Xue Li,Qingchao Gao,Xueyan Ren et al.
Xue Li et al.
The pathogen Geotrichum citri-aurantii causes postharvest sour rot disease in citrus fruit worldwide, severely impacting the commercial development and economic value of citrus. However, research on G. citri-aurantii commenced relatively la...
The ArWOX11-ArNRPM3 Module Decreases Drought Tolerance Through Abscisic Acid Signal Pathway in Anoectochilus roxburghii [0.03%]
胡黄连脱水素模块通过脱落酸信号途径降低干旱耐受性
Aimin Lv,Yu Zhang,Yanqin Zhu et al.
Aimin Lv et al.
Drought stress inhibits the growth and development of Anoectochilus roxburghii, and WUSCHEL-related homeobox (WOX) transcription factors participate in plant growth and abiotic stress responses. However, the mechanism of the WOX-regulated d...
Revisiting the Influence of Young White Wine Composition on Ester Evolution [0.03%]
白葡萄酒Composition对酯演变的影响研究
Diana A Martin-Rojas,Tatjana Radovanović Vukajlović,Martin Šala et al.
Diana A Martin-Rojas et al.
The evolution of volatile esters is a key determinant of the sensory profile of young white wines during the storage. This study evaluates the stability of 17 esters in 32 commercial wines under forced aging conditions. Although ester hydro...
A Pheromone-Dominant Odorant-Binding Protein Mediates Mating and Host Volatile Perception in Anomala corpulenta [0.03%]
一种信息素主导的气味结合蛋白介导了沟金针虫对交配和寄主挥发物的感知
Huanhuan Dong,Jinqiao Li,Ertao Li et al.
Huanhuan Dong et al.
The scarab beetle Anomala corpulenta is a significant agricultural pest, causing crop damage through adult feeding and larval root destruction. Targeting its sex pheromone system provides a promising eco-friendly pest control strategy. Pher...
Csi-Bantam Delivered by Clonorchis sinensis Extracellular Vesicles Promotes Liver Fibrosis via Targeting TRIM35 [0.03%]
由肝吸虫分泌的外泌体蛋白质Csi-Bantam通过靶向TRIM35促进肝纤维化
Xuewei Liu,Meiru Hou,Wei Wei et al.
Xuewei Liu et al.
Freshwater fish is widely consumed, yet raw or undercooked freshwater fish can transmit foodborne zoonotic pathogens. Clonorchiasis, caused by Clonorchis sinensis, is a major foodborne parasitic disease associated with hepatobiliary injury ...
Spectral Characterization, Isomerization Behavior, and Antioxidant Activity of ζ-Carotene Geometric Isomers: From Biosynthetic Intermediates to Functional Ingredients [0.03%]
ζ-胡萝卜素几何异构体的光谱表征、互变异构行为及抗氧化活性：从生物合成中间产物到功能成分
Mitsuya Ito,Yuki Nishimura,Kazumi Sawada et al.
Mitsuya Ito et al.
ζ-Carotene is a key biosynthetic intermediate of lycopene that is widely distributed in plants and fungi but difficult to purify, which has limited detailed physicochemical and biological studies. Here, we established a purification strate...