Discovery of 10-Shogaol from Zingiber officinale with Broad Antiviral and Anti-inflammatory Activity against Dengue and Zika Viruses Using Activity-Guided Molecular Networking [0.03%]
从姜黄中发现具有广谱抗病毒和抗炎活性的10-石薄荷醇：针对登革热和寨卡病毒的活性导向分子网络分析
Mengxue Li,Renyu Zhou,Lei Guo et al.
Mengxue Li et al.
The bioactive constituents of ginger (Zingiber officinale Roscoe) display well-documented immunomodulatory and antimicrobial effects; however, the role of these components in combating dengue virus (DENV) and other flaviviruses infection re...
Cross-Talk Between a Nematode Effector-Targeted Metabolic Enzyme and a Lectin Receptor Kinase Regulates Wheat Immunity [0.03%]
wheat免疫调控中的一个效应物靶向代谢酶和一个凝集素受体激酶的互作
Fayu Li,Wei Zhao,Manyu Chen et al.
Fayu Li et al.
The cereal cyst nematode (Heterodera avenae) is an obligate plant parasite that severely threatens wheat production. Previous studies have shown that its secreted effector HaGLAND5, suppresses host immunity and promotes nematode parasitism ...
Crt-miR166a, a Citrus-Derived MicroRNA, Modulates the Gut Microbiota-Metabolites under High-Fat Diet [0.03%]
柑橘来源的微小核糖核酸Crt-miR166a调节高脂饮食下的肠道微生物群-代谢物
Minmin Zhan,Chenxi Zhao,Bin Chen et al.
Minmin Zhan et al.
High-fat diet (HFD) induces dysregulation of gut microbiota-derived metabolites, including short-chain fatty acids, bile acids, and indole derivatives. Although microRNAs (miRNAs) are known to regulate gut microbiota composition, the effect...
Rational Design, Structural Optimization, Synthesis, Biological Assessment, and Theoretical Validation of Novel HPPD-Targeting Herbicides Based on Computational Chemistry [0.03%]
基于计算化学的新型HPPD靶向除草剂的设计、合成、评估及验证
Yue Li,Dmitry B Rubinov,Veronica G Zinovich et al.
Yue Li et al.
4-Hydroxyphenylpyruvate dioxygenase (HPPD; EC 1.13.11.27) is regarded as a critical target enzyme in herbicide discovery and rational design. In this study, a series of 3-aroylpyridine-2,4(1H,3H)-diones were designed as potential HPPD inhib...
Cobamide Fingerprints in Foods: A Molecular Framework for Re-Evaluating Dietary Vitamin B12 Sources [0.03%]
膳食维生素B12来源的甲钴胺指纹：重新评估的分子框架
Fumio Watanabe,Kyohei Koseki,Tomohiro Bito
Fumio Watanabe
Vitamin B12 is synthesized exclusively by certain bacteria and archaea and is generally absent from unfortified plant-derived foods. However, food composition data often rely on microbiological assays that lack chemical specificity and may ...
Engineering a Robust Glucose Oxidase for Juice Preservation: Enhanced Catalytic Performance Drives Browning Inhibition and Shelf Life Extension [0.03%]
工程化用于果汁保鲜的耐药葡萄糖氧化酶：增强催化性能驱动抑制褐变和延长保质期
Ying-Zhi Peng,Jing Li,Xin-Cheng Jiang et al.
Ying-Zhi Peng et al.
Glucose oxidase (GOX) is widely recognized for its potential in food preservation, yet its practical application is often limited by insufficient stability and catalytic efficiency under processing conditions. In this study, a GOX from Aspe...
circFAM129B Regulates Adipogenesis and Unsaturated Fatty Acid Synthesis by bta-let-7d in Buffalo Intramuscular Preadipocytes [0.03%]
circFAM129B通过bta-let-7d调控水 buffalo 瘦肉中的前脂肪细胞的脂质生成和不饱和脂肪酸合成
Hao Tian,Fangfang Zou,Ruirui Zhu et al.
Hao Tian et al.
Intramuscular fat (IMF) and unsaturated fatty acid (UFA) contents are critical factors influencing meat quality in livestock. Circular RNAs (circRNAs) have recently emerged as key regulators in lipid metabolism. However, their roles in IMF ...
Design, Synthesis, and Fungicidal Activity of Pyrimidinamine Derivatives as Novel Complex I Inhibitors [0.03%]
新型复杂I抑制剂的嘧啶胺衍生物的设计、合成及抗菌活性研究
Wen-Feng Jia,Yu-Shun Xia,Qiang-Hui Lu et al.
Wen-Feng Jia et al.
To develop novel fungicides targeting complex I, a series of pyrimidinamine derivatives bearing a dichloropropene ether moiety were designed and synthesized via the intermediate derivatization method. Their structures were confirmed by 1H/1...
Comparative Evaluation of Total Ergot Alkaloids Determination by ELISA and UHPLC-MS/MS in Wheat: Implications of Cross-Reactivity and Matrix Effects [0.03%]
一种测定小麦中全部麦角生物碱的ELISA与UHPLC-MS/MS法比较评价：交叉反应及基质效应的影响
Chamali Kodikara,Dainna Drul,Nandika Bandara et al.
Chamali Kodikara et al.
Ergot alkaloids (EAs) are toxic secondary metabolites found in cereal grains that require effective monitoring strategies. This study evaluated a commercially available enzyme-linked immunosorbent assay (ELISA) for total ergot alkaloids aga...
Novel Robust-Thermostable Zearalenone Hydrolase Engineered via Ancestral Sequence Reconstruction: In Silico Design, In Vitro Characterization, and In Vivo Efficacy Evaluation [0.03%]
基于祖先序列重建工程化创制新型抗干扰及耐热的玉米赤霉烯酮水解酶：计算设计，体外表征和体内功效评价
Yanan Wang,Qianqian Wang,Xinlan Liu et al.
Yanan Wang et al.
Despite the high efficiency of zearalenone (ZEN) hydrolases in detoxifying ZEN, the limited thermostability restricts their industrial application. This study employed ancestral sequence reconstruction to enhance the thermostability of a no...