Insights in Food Allergy from DCs: The Influence and Mechanism of Diet Components with Antiallergic Properties [0.03%]
Ling Li,Shuping Chen,Yan Zhao et al.
Ling Li et al.
Food allergy (FA), defined as abnormal immunological response to certain food proteins, is a serious issue in food safety and public health. Dendritic cells (DCs) orchestrate tolerance or allergic reactions to food proteins. Accumulating re...
Functional Characterization of Helicoverpa armigera Nicotinic Acetylcholine Receptor Subunits Targeted by cis- and trans-Configuration Piperidine Alkaloids in Solenopsis Fire Ant Venom [0.03%]
Xi Sun,Guangyu Wang,Yanxia Cheng et al.
Xi Sun et al.
Piperidine alkaloids in Solenopsis invicta venom are natural substances with insecticidal activity. Their structural diversity provides a model for investigating structure-activity relationships to develop novel targeted insecticides. Using...
Unraveling the Mechanism of Action: Novel Steroidal Piperidone Compound I-9 Targets Pyruvate Kinase in the Rhopalosiphum padi [0.03%]
Mengfan Qin,Jinyan Wang,Qi Zhan et al.
Mengfan Qin et al.
Aphids are important worldwide pests in crop production. Steroidal Piperidone Compound I-9 exhibits high insecticidal activity against aphids, but its aphidicidal mechanism remains unclear. In this study, drug affinity responsive target sta...
Antagonistic Mechanisms of Iturin A-4 Derived from Bacillus velezensis ZC2-4 against Sporisorium scitamineum [0.03%]
Ruqing Feng,Ming Wei,Xuna Zhang et al.
Ruqing Feng et al.
Sugarcane smut, caused by Sporisorium scitamineum, is a globally destructive disease that severely threatens sugarcane production. In this study, we isolated an endophytic bacterium, Bacillus velezensis ZC2-4, which exhibits inhibitory acti...
Wenjia Wang,Xiao Liu,Yiping Liang et al.
Wenjia Wang et al.
Dysphagia is a common clinical symptom, often accompanied by insufficient lubrication of the oral cavity and pharynx, which reduces eating efficiency and nutrient intake, increases the risk of complications such as aspiration pneumonia. Art...
Enhancing the Promiscuous Phosphorylation Activity of Acid Phosphatase via Transition-State-Stabilization-Mediated Screening Strategy [0.03%]
Wei Song,Xin Xu,Wanqing Wei et al.
Wei Song et al.
Acid phosphatases primarily catalyze phosphate ester hydrolysis, yet some members exhibit promiscuous phosphotransferase activity, enabling substrate phosphorylation using inexpensive inorganic phosphate. This catalytic promiscuity provides...
Green Mold of Citrus: Recent Insights into Penicillium digitatum Pathogenicity and Biological Control Strategies [0.03%]
绿霉菌病害研究进展：串珠青霉的致病机理及生物防治策略近期新进展
Evandro Silva,Maria Clara Santana Aguiar,Eder de Vilhena Araújo et al.
Evandro Silva et al.
P. digitatum, the causal agent of citrus green mold, remains the most destructive postharvest pathogen of citrus worldwide. Recent advances have greatly expanded our understanding of the molecular dialogue between P. digitatum and citrus ho...
Discovery of Novel FXIa Inhibitory Peptides from Deep-Sea Gigantidas platifrons Hydrolysates: AI-Guided Screening, Anticoagulant Activity, and Mechanistic Insights [0.03%]
基于AI的筛选：发现具有抑制FXIa活性和抗凝血作用的新肽及机制研究
Yuhong Ouyang,Hao Chen,Jing Wang et al.
Yuhong Ouyang et al.
The development of anticoagulants targeting coagulation factor XIa (FXIa) is a promising strategy to reduce thrombotic risk while minimizing bleeding complications. However, FXIa inhibitory peptides derived from the deep sea remain largely ...
Oxymatrine: Hepatoprotective Effects of a Multitarget Natural Alkaloid [0.03%]
氧基麻黄碱：一种多靶标天然生物碱的肝保护作用
Ye Zhang,Xianyi Ding,Muge Zhou et al.
Ye Zhang et al.
Liver diseases are a major global health burden with an occult onset and atypical symptoms, hindering early diagnosis. Herbal medicines feature low toxicity and multitarget effects; oxymatrine (OMT) from Sophora flavescens possesses anti-in...
Soybean SUMO Protease GmOTSa Targets the GmLOX31 to Promote Drought and Salt Tolerance in Soybean [0.03%]
大豆SUMO蛋白酶GmOTSa通过靶向降解GmLOX31促进大豆耐旱和耐盐性
Sibo Wang,Jingsong Guo,Shaoqing Gao et al.
Sibo Wang et al.
Soybean productivity is significantly impacted by drought and salt stress, yet the precise molecular mechanisms responsible for abiotic stress tolerance mediated by the SUMO protease GmOTSa remain unclear. To address this gap, GmOTSa-overex...