Solid-phase synthesis of a combinatorial array of 1,3-bis(acylamino)-2-butanones, inhibitors of the cysteine proteases cathepsins K and L [0.03%]
用于抑制半胱氨酸蛋白酶cathepsins K和L的1,3-双（酰胺基）-2-丁酮组合阵列固相合成
D S Yamashita,X Dong,H J Oh et al.
D S Yamashita et al.
To more rapidly prepare members of the 1,3-bis(acylamino)-2-butanone class of cysteine protease inhibitors, a solid-phase synthesis was developed. 1-Azido-3-amino-2,2-dimethoxybutane (4), which has the two amino groups differentiated and th...