A combinatorial approach to studying the effects of N-alkyl groups on poly(N-alkyl and N,N-dialkylacrylamide) solubility [0.03%]
N-烷基取代对聚（N-烷基丙烯酰胺和N，N-二烷基丙烯酰胺）溶解度影响的组合方法研究
David E Bergbreiter,Nydea A Avilés-Ramos,Denisse Ortiz-Acosta
David E Bergbreiter
Soluble polymers including poly(N-alkylacrylamide)s with low mole percent loadings of pendant groups are of interest in applications in catalysis, synthesis, sequestration, and soluble affinity chromatography where their thermal and phase-d...
Parallel synthesis and yeast growth inhibition screening of succinamic acid libraries [0.03%]
琥珀酰胺酸类化合物的并行合成及其抑酵活性筛选研究
Pedro Serrano,Josefina Casas,Amadeu Llebaria et al.
Pedro Serrano et al.
Libraries of succinamic acid derivatives resulting from the condensation of a series of succinic acid derivatives with amines are reported as putative khafrefungin analogues. A total of 480 compounds derived from the initial condensation of...
Design and synthesis of a cell-permeable synthetic transcription factor mimic [0.03%]
细胞渗透型合成转录因子模似物的设计与合成
Xiangshu Xiao,Peng Yu,Hyun-Suk Lim et al.
Xiangshu Xiao et al.
Synthetic molecules capable of activating the expression of specific genes are of great interest as tools for biological research and, potentially, as a novel class of pharmaceutical agents. It has been demonstrated previously that such syn...
Synthesis of thieno[2,3-d]pyrimidin-2-ylmethanamine combinatorial library with four diversity points [0.03%]
四个多样性位点的噻诺并[2,3-d]吡啶甲胺组合文库合成
Andrey V Bogolubsky,Sergey V Ryabukhin,Svetlana V Stetsenko et al.
Andrey V Bogolubsky et al.
The parallel solution-phase synthesis of more than 230 substituted thieno[2,3-d]pyrimidin-2-ylmethanamines has been accomplished. This strategy is based on the cyclization of 2-aminothiophen-3-carboxylates with chloroacetonitrile to constru...
Optimization of three- and four-component reactions for polysubstituted piperidines: application to the synthesis and preliminary biological screening of a prototype library [0.03%]
用于合成多取代哌啶原型化合物库的三组分和四组分反应优化及初步生物活性筛选研究
Agnieszka Ulaczyk-Lesanko,Eric Pelletier,Maria Lee et al.
Agnieszka Ulaczyk-Lesanko et al.
Several solid- and solution-phase strategies were evaluated for the preparation of libraries of polysubstituted piperidines of type 7 using the tandem aza[4+2]cycloaddition/allylboration multicomponent reaction between 1-aza-4-boronobutadie...
Parallel solution-phase synthesis of 4H-benzo[1,4]thiazin-3-one and 1,1-dioxo-1,4-dihydro-2H-1lambda6-benzo[1,4]thiazin-3-one derivatives from 1,5-difluoro-2,4-dinitrobenzene [0.03%]
由1,5-二氟-2,4-二硝基苯合成4H-和1,1-二氧化-1,4-二氢-2H-苯并[1,4]噻嗪-3-酮类化合物的平行溶液相法
Zhanguo Wang,Yunyun Yuan,Yuyan Chen et al.
Zhanguo Wang et al.
This paper discusses the synthesis of privileged structures 4H-benzo[1,4]thiazin-3-one and 1,1-dioxo-1,4-dihydro-2H-1lambda6-benzo[1,4]thiazin-3-one derivatives in a parallel solution-phase manner using 1,5-difluoro-2,4-dinitrobenzene. Each...
Systematic solution-phase parallel synthesis of active vitamin D3 analogs with elongated side chains and their cell differentiation activities [0.03%]
具有延长侧链的活性维生素D3类似物的系统溶液相平行合成及其细胞分化活性
Yoshiyuki Ono,Hirotaka Kashiwagi,Tohru Esaki et al.
Yoshiyuki Ono et al.
Side-chain elongation of active vitamin D3 is acknowledged as a structural modification to enhance its cell differentiation activity; however, the comprehensive structure-activity relationship (SAR) as a result of this modification has not ...
An efficient method for solution-phase parallel synthesis of 2-quinoxalinol salen Schiff-base ligands [0.03%]
一种高效构建2-喹喔啉醇-沙利文基配体的溶液相平行合成方法
Xianghong Wu,Anne E V Gorden
Xianghong Wu
A solution-phase parallel method for the synthesis of 2-quinoxalinol salen ligands was designed and optimized. The synthesis begins with commercially available 1,5-difluoro-2, 4-dinitrobenzene (DFDNB) and employs a sequence of five straight...
Lidia Feliu,Patricia Vera-Luque,Fernando Albericio et al.
Lidia Feliu et al.
A traceless approach for the solid-phase parallel synthesis of trisubstituted oxindoles [0.03%]
三取代氧吲哚固相平行合成的无痕方法研究
Jinwen Xie,Jing Sun,Guolin Zhang et al.
Jinwen Xie et al.