Preparation, characterization, and application of poly(vinyl alcohol)-graft-poly(ethylene glycol) resins: novel polymer matrices for solid-phase synthesis [0.03%]
聚乙烯醇接枝聚乙二醇树脂的制备、表征及应用：固相合成用新型聚合物基质
Juntao Luo,Christophe Pardin,X X Zhu et al.
Juntao Luo et al.
Spherical crosslinked poly(vinyl alcohol) (PVA) beads with good mechanical stability were prepared by reverse-suspension polymerization, using dimethyl sulfoxide (DMSO) as a cosolvent in an aqueous phase. Poly(ethylene glycol)s with varying...
Scaffold-directed traceless synthesis of tetrahydro-beta-carbolinehydantoins [0.03%]
导向合成四氢-β-碳啉氨达喃化合物
Chih-Hau Chen,Chia-Mao Chang,Hsia-Yuan Chen et al.
Chih-Hau Chen et al.
Pharmacologically interesting tetrahydro-beta-carbolinehydantoins have been prepared through four-step traceless synthesis by a combinatorial approach. Two-arm PEG 1 (MW approximately 4000) was used as a soluble polymer support and reacted ...
Peptide-heterocycle hybrid molecules: solid-phase-supported synthesis of substituted N-terminal 5-aminotetrazole peptides via electrocyclization of peptidic imidoylazides [0.03%]
肽类-杂环共轭分子：通过肽基咪唑亚胺盐的电环化反应固相合成N端取代的5-氨基四氮唑肽类化合物
Julia I Gavrilyuk,Ghotas Evindar,Jin Yu Chen et al.
Julia I Gavrilyuk et al.
A method for the synthesis of polypeptides modified with a tetrazole ring at the N-terminus is described. Reaction of the N-terminal amino group of solid-supported peptides with arylisothiocyanates generates thiourea intermediates, which up...
High-throughput screening using porous photoelectrode for the development of visible-light-responsive semiconductors [0.03%]
基于多孔光电极的高通量筛选可见光响应半导体材料的研究
Takeo Arai,Yoshinari Konishi,Yasukazu Iwasaki et al.
Takeo Arai et al.
A high-throughput screening system for new visible-light-responsive semiconductors for photoelectrodes and photocatalysts was developed in this study. Photoelectrochemical measurement was selected to evaluate visible-light responsiveness, a...
Synthesis of novel N-rich polycyclic skeletons based on azoles and pyridines [0.03%]
基于唑类和吡啶的新型富氮并环骨架的合成
Sunil Sharma,Biswajit Saha,Devesh Sawant et al.
Sunil Sharma et al.
An efficient method for the synthesis of new polycyclic skeletons: triaza-benzofluorenes and triaza-pentalenonaphthalene from bicyclic privileged structures imidazopyridine and imidazothiazole, respectively, has been described using the Pic...
Design and synthesis of a 3,4-dehydroproline amide discovery library [0.03%]
3,4-脱氢脯氨酸酰胺发现化合物库的设计与合成
Stefan Werner,Dhanalakshmi Kasi,Kay M Brummond
Stefan Werner
The synthesis of a discovery library of 80 3,4-dehydroproline amides was achieved in a four-step reaction sequence from easily accessible 3-aminoallene-3-carboxylate methyl esters. Diversification of these proline mimics was introduced at f...
Combinatorial solution-phase synthesis of alkyl (1S*,2S*,3R*,5R*,6R*)-1-alkyl-3-aryl-6-benzoylamino-1-hydroxy-7- oxo-5-phenylhexahydropyrazolo[1,2-a]pyrazole-2-carboxylates [0.03%]
新型杂环化合物的组合化学合成法研究
Lidija Pezdirc,David Bevk,Uros Groselj et al.
Lidija Pezdirc et al.
Combinatorial solution-phase cycloadditions of (1Z,4R*,5R*)-4-benzoylamino-5-phenylpyrazolidin-3-on-1-azomethine imines 3 to beta-keto esters 4 afforded a library of 26 bicyclic pyrazolidinones 5 in 6-89% yields and in 14-100% de. All produ...
Survey of the diversity space coverage of reported combinatorial libraries [0.03%]
关于所报道的组合化学库多样性空间覆盖情况的调查研究
Sara H Fitzgerald,Michal Sabat,H Mario Geysen
Sara H Fitzgerald
Courtesy of the annual collections reported by Roland E. Dolle in the Journal of Combinatorial Chemistry, all three-point diverse libraries reported in the literature since 1992 have been evaluated according to their similarity at the libra...
Controlled peptide solvation in portion-mixing libraries of FRET peptides: improved specificity determination for Dengue 2 virus NS2B-NS3 protease and human cathepsin S [0.03%]
用于控制FRET肽部分混合库中肽溶剂化的肽溶解：改进登革热2型病毒NS2B-NS3蛋白酶和人类半胱氨酸天冬氨酸蛋白酶S的特异性确定
Fabiana M Alves,Izaura Y Hirata,Iuri E Gouvea et al.
Fabiana M Alves et al.
The solubility of peptides in aqueous buffers used for the enzyme assays is a common limitation for all peptide libraries. In principle, the more water-soluble peptides are, the more susceptible they will be to peptidase hydrolysis. We have...
Enhanced parallel synthesis efficiency through tandem Pd-catalyzed S- and N-arylation reactions: single-vessel formation of aminobenzothiazoles [0.03%]
通过串联Pd催化S-和N-芳基化反应提升增强型平行合成效率：单锅法构建氨基苯并噻唑类化合物
Matthew D Vera,Jeffrey C Pelletier
Matthew D Vera