Rapid identification of immunostimulatory alpha-galactosylceramides using synthetic combinatorial libraries [0.03%]
利用合成组合库快速鉴定免疫刺激α-半乳糖神经酰胺分子
Qian Li,Rachel M Ndonye,Petr A Illarionov et al.
Qian Li et al.
Two 60+-membered libraries of alpha-galactosylceramides have been prepared by reactions between activated ester resins and two core, fully deprotected galactosylated sphingoid bases. The libraries were evaluated for their ability to stimula...
Parallel synthesis of a lipopeptide library by hydrazone-based chemical ligation [0.03%]
基于腙类化合物固相偶联法的脂肽库合成
Pascaline Dubs,Line Bourel-Bonnet,Gilles Subra et al.
Pascaline Dubs et al.
alpha-Melanocyte-stimulating hormone (alpha-MSH) is an endogeneous linear tridecapeptide with potential application for the modulation of skin tanning. To evaluate the interest of introducing a lipid moiety onto this peptide, we developed a...
Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2006 [0.03%]
药物发现和化学生物学中的化学文库的全面调查：2006年
Roland E Dolle,Bertrand Le Bourdonnec,Allan J Goodman et al.
Roland E Dolle et al.
Solid-phase synthesis and modification of Thiazole Orange and its derivatives and their spectral properties [0.03%]
固相结合物合成及修饰胸腺素橙及其衍生物的光谱性能研究
Xuening Fei,Shaobin Yang,Baolian Zhang et al.
Xuening Fei et al.
A new solid-phase synthesis is shown to be effective in the preparation of cyanine dye Thiazole Orange (TO) and its derivatives, which can be obtained as a traceless cleavage of the Merrifield resin method. The influence of different solven...
meso-Tetra(pentafluorophenyl)porphyrin as an efficient platform for combinatorial synthesis and the selection of new photodynamic therapeutics using a cancer cell line [0.03%]
基于癌细胞系的光动力治疗药物的筛选及组合合成的有效平台：中间位四（五氟苯基）卟啉
Diana Samaroo,Mikki Vinodu,Xin Chen et al.
Diana Samaroo et al.
The four para fluoro groups on 5,10,15,20-tetrakis-(2,3,4,5,6-pentafluorophenyl)-porphyrin (TPPF20) are known to react with a variety of nucleophiles, but the reaction conditions for this substitution reaction depend on the nature of the nu...
Expedient Lewis acid catalyzed synthesis of a 3-substituted 5-arylidene-1-methyl-2-thiohydantoin Library [0.03%]
一步合成含硫杂并四苯取代基库的新方法
Brian T Gregg,Kathryn C Golden,John F Quinn et al.
Brian T Gregg et al.
An efficient and rapid solution phase combinatorial synthesis of a 3-substituted 5-arylidene-1-methyl-2-thiohydantoin library was developed. The salient feature for this library production procedure is the addition of the Lewis acid catalys...
Natural products in parallel chemistry--novel 5-lipoxygenase inhibitors from BIOS-based libraries starting from alpha-santonin [0.03%]
基于生物素的库发现裂环环烯醚萜类茋天然产物是α-桑松烃的新型5-脂氧合酶抑制剂
Oliver Schwarz,Sven Jakupovic,Horst-Dieter Ambrosi et al.
Oliver Schwarz et al.
Recently, we developed a concept known as biology-oriented synthesis (BIOS), which targets the design and synthesis of small- to medium-sized compound libraries on the basis of genuine natural product templates to provide screening compound...
Diversification of the three-component coupling of 2-aminoheterocycles, aldehydes, and isonitriles: efficient parallel synthesis of a diverse and druglike library of imidazo- and tetrahydroimidazo[1,2-a] heterocycles [0.03%]
2-氨基杂环与醛和异氰的三组分偶联衍生化反应：高效并行合成药物分子样亚胺硫杂环化合物库
Timothy Kercher,Chang Rao,Josef R Bencsik et al.
Timothy Kercher et al.
Due to their diverse range of biological activities, imidazoheterocycles are recognized as privileged structures making these structural motifs attractive targets for library preparation. We report herein the synthesis of a sizable collecti...
Parallel solution-phase synthesis of 2-alkylthio-5-arylidene-3,5-dihydro-4H-imidazol-4-one by one-pot three-component domino reaction [0.03%]
一锅三组分串联反应合成2-烷基硫代-5-芳亚甲基-1,3,5-二氢-4H-咪唑-4-酮类化合物
Stéven Renault,Sarah Bertrand,François Carreaux et al.
Stéven Renault et al.
A practical protocol for the preparation of a parallel solution-phase library of 5-arylidene imidazolone is reported. Target compounds were obtained in good yield, stereoselectively, and purity by one-pot domino reaction from various thiohy...
Microwave-enhanced one-pot synthesis of diversified 3-acyl-5-hydroxybenzofurans [0.03%]
一步微波合成多样的3-酰基-5-羟基苯并呋喃类化合物
Xia-Min Cheng,Xue-Wei Liu
Xia-Min Cheng