Parallel synthesis of 1,3-dihydro-1,4-benzodiazepine-2-ones employing catch and release [0.03%]
利用捕捉和释放并行合成1,3-二氢-1,4-苯并二氮杂卓-2-酮类化合物
Line S Laustsen,Christian K Sams
Line S Laustsen
An efficient solid-phase method has been developed for the parallel synthesis of 1,3-dihydro-1,4-benzodiazepine-2-one derivatives. A key step in this procedure involves catching crude 2-aminobenzoimine products 4 on an amino acid Wang resin...
Mei-Jung Lin,Wei Zhang,Chung-Ming Sun
Mei-Jung Lin
The fluorous traceless synthesis of substituted indole alkaloids is carried out first by attaching the 3-(perfluorooctyl)propanol with Boc protected L-tryptophan. The reaction of perfluoroalkyl (Rfh)-tagged tryptophan esters with various al...
Melissa R Jeddeloh,Jason B Holden,Dustin H Nouri et al.
Melissa R Jeddeloh et al.
Parallel solution phase methods for the preparation of a 72-membered 3-aryl-4,5-dihydroisoxazole-5-carboxamide library is reported. The reaction order (nitrile oxide 1,3-dipolar cycloaddition followed by amide formation, or vice versa) was ...
Efficient solid-phase synthesis of 3-substituted-5-oxo-5H-thiazolo[2,3-b]-quinazoline-8-carboxamides under mild conditions with two diversity positions [0.03%]
温和条件下含两个多样性位置的3-取代-5-氧代-5H-噻唑并[2,3-b]喹唑啉-8-甲酰胺类化合物固相合成研究
Isabelle Bouillon,Viktor Krchnák
Isabelle Bouillon
Highly efficient solid-phase synthesis of thiazolo[2,3,b]quinazolines under mild conditions was developed using resin-bound 2-amino-terephthalamic acid, Fmoc-NCS, and bromoketones. Primary amines immobilized to an acid-cleavable backbone am...
Combinatorial dapoxyl dye library and its application to site selective probe for human serum albumin [0.03%]
用于人血清白蛋白位点选择性探针的达泊西啶染料组合库及其应用
Jaeki Min,Jae Wook Lee,Young-Hoon Ahn et al.
Jaeki Min et al.
The combinatorial fluorescent dapoxyl dye library was prepared by both solution- and solid-phase synthesis, generating 80 unique dapoxyl derivatives. A fluorescence-based screening toward human serum albumin (HSA) found one highly sensitive...
Traceless liquid-phase synthesis of biphenyls and terphenyls using pentaerythritol as a tetrapodal soluble support [0.03%]
以五味子醇酯为四臂可溶性支撑的联苯和三联苯的无痕液相合成法
Chul-Bae Kim,Chul-Hee Cho,Chang Keun Kim et al.
Chul-Bae Kim et al.
Application of a novel sulfonate-based traceless multifunctional linker system using pentaerythritol as a tetrapodal soluble support was demonstrated using liquid-phase parallel and combinatorial preparation of biphenyl and terphenyl compou...
Novel non-PEG derived polyethers as solid supports. 2. Solid-phase synthesis studies [0.03%]
新型非PEG衍生的聚醚固相合成支持物的研究与发展
Gabriel Cavalli,Andrew G Shooter,David A Pears et al.
Gabriel Cavalli et al.
Novel non-PEG derived polyether resins, coined SLURPS (Superior Liquid Uptake Resins for Polymer-supported Synthesis), were studied for their performance in solid-phase synthesis. Novel amino functional resins, SLURPS-NH2, were prepared wit...
Sergey V Ryabukhin,Andrey S Plaskon,Dmitriy M Volochnyuk et al.
Sergey V Ryabukhin et al.
Chlorotrimethylsilane (TMSCl) has been utilized as an efficient promoter and water scavenger in the Knoevenagel condensations of aromatic aldehydes with various methylene active compounds. High yields and a simple workup of target compounds...
Kinetics of hydrogen production of methanol reformation using Cu/ZnO/Al2O3 catalyst [0.03%]
甲醇制氢反应中Cu/ZnO/Al2O3催化剂的活性及稳定性研究
Ho-Shing Wu,Shun-Chang Chung
Ho-Shing Wu
The catalytic performance of methanol reformation using Cu/ZnO/Al2O3 was investigated at low temperature. The operation conditions, such as composition of Cu, Zn, and Al, temperature, molar ratio of H2O/CH3OH, weight hourly space velocity, ...
Synthesis of N-alkyl-octahydroisoquinolin-1-one-8-carboxamide libraries using a tandem Diels-Alder/acylation sequence [0.03%]
通过Diels-Alder反应/酰化串联合成N-烷基-八氢异喹啉酮-8-羧酰胺类化合物库
Kevin J Frankowski,Erin E Hirt,Yibin Zeng et al.
Kevin J Frankowski et al.
A synthetic sequence was developed in which a diene containing an attached secondary amine was reacted with maleic anhydride to afford the title structures in one step. The reaction involves a Diels-Alder reaction combined with a transacyla...