Skeletal diversity in small-molecule synthesis using ligand-controlled catalysis [0.03%]
基于配体调控催化的分子多样性合成研究
B Lawrence Gray,Stuart L Schreiber
B Lawrence Gray
Two Pd-catalyzed reductive transformations of diynes tethered through a silyl ether linkage were developed, where the reaction outcomes were controlled solely by selection of phosphine ligand. We screened Pd precatalysts, ligands, and addit...
The development of a semiautomated procedure for the synthesis and screening of a large group of molecularly imprinted polymers [0.03%]
一种合成及筛选大量分子印迹聚合物的半自动程序的发展
Myra T Koesdjojo,Henrik T Rasmussen,Adam M Fermier et al.
Myra T Koesdjojo et al.
A method for synthesis and evaluation of molecularly imprinted polymers (MIPs) on a semiautomated miniature scale is reported. This technique combines molecular imprinting with the combinatorial chemistry approach, allowing rapid screening ...
Alkyl chain length effects on copolymerization kinetics of a monoacrylate with hexanediol diacrylate [0.03%]
含不同烷基链长的单丙烯酸酯与己二醇二丙烯酸酯共聚动力学研究
Peter M Johnson,Jeffrey W Stansbury,Christopher N Bowman
Peter M Johnson
Copolymerizations of hexanediol diacrylate with three monoacrylates were analyzed using high-throughput conversion analysis to elucidate the effects of varying alkyl pendant groups at different compositions. Each analyzed copolymerization s...
Microwave-assisted combinatorial synthesis of polysubstituent imidazo[1,2-a]quinoline, pyrimido[1,2-a]quinoline and quinolino[1,2-a]quinazoline derivatives [0.03%]
微波促进的多取代imidazo[1,2- a]喹啉，pyrimido[1,2-a]喹啉和quinolino[1,2-a]喹唑啉衍生物组合合成
Shujiang Tu,Chunmei Li,Guigen Li et al.
Shujiang Tu et al.
A series of unusual fused heterocyclic compound derivatives, consisting of a pyridine and a imidazole or pyrimidine core, with a bridgehead nitrogen, were successfully synthesized by a microwave-assisted, three-component domino reaction of ...
Design and synthesis of novel tricycles based on 4H-benzo[1,4]thiazin-3-one and 1,1-dioxo-1,4-dihydro-2H-1lambda6-benzo[1,4]thiazin-3-one [0.03%]
基于4H-苯并[1,4]噻嗪-3-酮和1,1-二氧-1,4-二氢-2H-[1λ6]-苯并[1,4]噻嗪-3-酮的新型三环化合物的设计与合成
Li Li,Zhanguo Wang,Yuyan Chen et al.
Li Li et al.
This paper reports our recent efforts to develop novel tricycles based on 4H-benzo[1,4]thiazin-3-one ( 2) and 1,1-dioxo-1,4-dihydro-2H-1lambda(6)-benzo[1,4]thiazin-3-one (3) using 1,5-difluoro-2,4-dinitrobenzene (1). All of these tricycles ...
G K Surya Prakash,Csaba Weber,Sujith Chacko et al.
G K Surya Prakash et al.
Solid phase synthesis of highly substituted tetrahydropyrans by tandem ene-reaction/intramolecular Sakurai cyclization [0.03%]
固相合成高度取代的四氢吡喃：串联ene反应/分子内Sakurai环化反应
Sylvain Broussy,Herbert Waldmann
Sylvain Broussy
A solid-phase tandem ene-reaction/intramolecular Sakurai cyclization sequence has been developed to synthesize highly substituted tetrahydropyran derivatives in two steps from aldehydes and with complete control of the relative stereochemis...
Convenient synthesis of 2,7-naphthyridine Lophocladines A and B and their analogues [0.03%]
苯并菲啶类生物碱洛波氯定A和B及其类似物的合成
Ao Zhang,Chunyong Ding,Chen Cheng et al.
Ao Zhang et al.
A general method for designing combinatorial peptide libraries decodable by amino acid analysis [0.03%]
一种通用的组合肽库设计方法及其氨基酸分析解码法
Jacob Kofoed,Jean-Louis Reymond
Jacob Kofoed
Herein we describe an algorithm for designing combinatorial peptide libraries for split-and-mix synthesis on solid support that are decodable by amino acid analysis (AAA) of the beads. AAA is a standard service analysis available in most bi...
Solution-phase parallel synthesis of diverse 1,5-benzodiazepin-2-ones [0.03%]
溶液相平行合成多樣的1,5-苯并二氮杂卓-2-酮类化合物
Hai-Yan Zhao,Gang Liu
Hai-Yan Zhao
A practical and efficient parallel method has been developed for the synthesis of 1,5-benzodiazepin-2-ones with a large variety of substituents at the 3-, 4-, 5-, 7-, and 8-positions using 1,5-difluoro-2,4-dinitrobenzene as the starting mat...