Multistep synthesis on SU-8: combining microfabrication and solid-phase chemistry on a single material [0.03%]
基于SU-8的多步合成：在单一材料上结合微细加工和固相化学反应
Gabriel Cavalli,Shahanara Banu,Rohan T Ranasinghe et al.
Gabriel Cavalli et al.
SU-8 is an epoxy-novolac resin and a well-established negative photoresist for microfabrication and microengineering. The photopolymerized resist is an extremely highly crosslinked polymer showing outstanding chemical and physical robustnes...
Parallel synthesis of an amide library based on the 6,8-dioxa-3-azabicyclo[3.2.1]octane scaffold by direct aminolysis of methyl esters [0.03%]
基于6,8-二氧杂-3-氮杂螺环[3.2.1]辛烷的酰胺库平行合成：甲酯直接氨解法
Fabrizio Machetti,Ilaria Bucelli,Giovanni Indiani et al.
Fabrizio Machetti et al.
An efficient synthesis of unsubstituted and substituted amides based on the 6,8-dioxa-3-azabicyclo[3.2.1]octane scaffold is described. The reaction, carried out at 60 degrees C in the absence of solvent, is characterized by its mildness and...
Combinatorial discovery of reusable noncovalent supports for enzyme immobilization and nonaqueous catalysis [0.03%]
用于酶固定化和非水催化的可重复使用非共价支撑物的组合发现
James Long,Gillian A Hutcheon,Andrew I Cooper
James Long
A simple and effective method is described for the preparation of enzyme-containing materials that possess excellent catalytic activity, mechanical strength, and reusability. Uniform spherical beads were produced via the colyophilization of...
Efficient use of Ellman safety-catch linker for solid-phase assisted synthesis of multivalent glycoconjugates [0.03%]
Ellman安全闭锁连接器在固相辅助合成价态糖缀合物中的高效应用
Alejandro Díaz-Moscoso,Juan M Benito,Carmen Ortiz Mellet et al.
Alejandro Díaz-Moscoso et al.
Mariela M Marani,Marta Paradís-Bas,Judit Tulla-Puche et al.
Mariela M Marani et al.
The one-bead-one-compound method gives access to millions of compounds that can be screened directly on the bead. Although characterization techniques are increasingly potent and reliable, problems can still be encountered in deciphering th...
Parallel synthesis of a novel C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) library [0.03%]
新型C2-芳基吡咯并[2,1-c][1,4]苯并二氮杂卓(PBD)库的平行合成法
Dyeison Antonow,Nectaroula Cooper,Philip W Howard et al.
Dyeison Antonow et al.
A 66-member C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) library has been successfully synthesized in parallel via Suzuki coupling using PS-PPh3Pd (catalyst) and PS-DEAM (scavenger) under microwave radiation. Library members were obtaine...
Priyanka Chaudhry,Frank Schoenen,Benjamin Neuenswander et al.
Priyanka Chaudhry et al.
The reactions of 1,2- and 1,3-hydroxyalkyl azides and aldehydes in the presence of Lewis acid result in the one-step construction of oxazolines and dihydrooxazines, respectively. The reaction was adapted to parallel synthesis using a polyme...
Solid-phase synthesis of sn-1,2- and sn-2,3-diacylglycerols via ring-opening of the glycidyl-bound resin [0.03%]
经开环反应制备甘油骨架C-1,2和C-2,3位双酰基甘油脂类化合物
Jin-soo Seo,Cheol Min Yoon,Young-Dae Gong
Jin-soo Seo
A general method developed for the parallel solid-phase synthesis of sn-1,2- and sn-2,3-diacyglycerol derivatives. The technique relies on the use of carboxylic acid-promoted epoxide ring-opening reactions of the glycidyl-bound resin 3. The...
Transition metal-catalyzed orthogonal solid-phase decoration of the 2(1H)-pyrazinone scaffold using a sulfur linker [0.03%]
基于硫链接臂的过渡金属催化正交固相2(1H)吡嗪酮骨架修饰反应
Nadya Kaval,Brajendra Kumar Singh,Denis S Ermolat&#x;ev et al.
Nadya Kaval et al.
A new transition metal-catalyzed orthogonal solid-phase protocol for the synthesis of highly substituted 2(1H)-pyrazinones was developed, on the basis of Chan-Lam arylation and Liebeskind-Srogl cross-coupling reactions. This strategy opens ...
Josep Farrera-Sinfreu,Fernando Albericio,Miriam Royo
Josep Farrera-Sinfreu
A synthetic method for the preparation of sulfamate peptidomimetics is described. The methodology allows sulfamoylation in the solid phase using sulfamoyl chloride in DMA, followed by the acylation of the corresponding sulfamoylated product...