Michelle K Brenner,Pamela A Christopherson,Veronica H Flood
Michelle K Brenner
Diagnosis of von Willebrand disease (VWD) is a challenge due to variability in laboratory assays, variability in patient von Willebrand factor (VWF) levels, and variability in the different types of VWD. Because of these challenges, it can ...
Rakhi P Naik,Rafal Pawlinski,Nigel S Key
Rakhi P Naik
The pathophysiology of venous thromboembolism (VTE) is complex. While perturbations in the coagulation system have generally been considered the primary driver of VTE risk, there is increasing recognition that additional whole-blood compone...
Arnaud Jaccard,Laurent Magy,Bertrand Arnulf et al.
Arnaud Jaccard et al.
Monoclonal gammopathy is observed in approximately 10% of patients with peripheral neuropathy, which is particularly common in those with the immunoglobulin M monoclonal component. The diagnostic challenge lies in determining whether the ne...
Nidhi Patel,Bethany Samuelson Bannow
Nidhi Patel
Pregnant persons with bleeding disorders (pwBD) have an increased risk of primary and secondary postpartum hemorrhage (PPH). Patients with von Willebrand disease, a bleeding disorder of unknown cause, or qualitative platelet defects (QPDs) ...
From treatment to biology and back: managing iron overload in transfused hemoglobinopathies [0.03%]
从治疗到生物学再回到治疗：输血依赖性珠蛋白生成障碍性贫血的铁过载管理
Thomas D Coates
Thomas D Coates
Before effective iron chelation became available, patients with transfusion-dependent thalassemia often died from iron-induced cardiomyopathy and endocrine failure in their second decade of life. This experience shaped long-standing expecta...
Gene transfer and genome editing of T cells for cancer immunotherapy: from allogeneic HSCT to TCR gene editing [0.03%]
T细胞基因转移和基因编辑用于癌症免疫治疗：从异体造血干细胞移植到TCR基因编辑
Chiara Bonini
Chiara Bonini
Adoptive T-cell therapy has emerged as a transformative modality in cancer immunotherapy, building upon foundational principles established in allogeneic hematopoietic stem cell transplantation. In this setting, while donor T cells mediate ...
Refractory ITP: revisiting definitions, diagnostics, and management paradigms [0.03%]
难治性ITP：重新审视定义、诊断和治疗模式
Sandhya R Panch,Ganesh Raman,James B Bussel
Sandhya R Panch
Immune thrombocytopenia (ITP) is a heterogeneous autoimmune disorder characterized by decreased platelet counts and a variable propensity for bleeding. Significant strides have delineated the pathophysiologic mechanisms of ITP and led to ne...
Molecular diagnostics 101: how to use genetic tests in classical hematology [0.03%]
分子诊断基础：如何在经典血液学中使用基因检测
Andrés Caballero-Oteyza,Miranda Di Biase,Xiao P Peng
Andrés Caballero-Oteyza
Increasing use of clinical diagnostic genomic assays over the past 2 decades has enabled us to expand our understanding of the clinical spectrum of known diseases, as well as the genetic landscape and paradigms surrounding diverse clinical ...
Yasmin Elgammal,Wenying Zhang,Theodosia A Kalfa
Yasmin Elgammal
Red cell disorders may present with overlapping clinical presentation and laboratory findings; in addition, complete phenotypic characterization of the patients' red cells is more challenging in the most severe cases, which are typically tr...
Diagnosis of bleeding disorder of unknown cause: how many tests are enough to diagnose BDUC? [0.03%]
不明原因出血倾向的诊断：多少项检查足以确诊？
Maria N Avgeropoulos,Paula D James
Maria N Avgeropoulos
The challenges associated with achieving a clear diagnosis in patients with a suspected bleeding disorder are evident in those who end up categorized as bleeding disorder of unknown cause (BDUC), which can contribute to uncertainty in manag...