Marlise R Luskin
Marlise R Luskin
Philadelphia chromosome-positive (Ph+) ALL is the most common genetic subtype of ALL and primarily affects adults. Ph+ ALL is characterized by the constitutively active ABL1 kinase and is resistant to conventional chemotherapy. Thus, Ph+ AL...
Matthias Stelljes
Matthias Stelljes
Antibody-based and cell-based novel immunotherapies, such as bispecific T-cell engagers (BiTE), antibody-drug conjugates, or chimeric antigen receptor (CAR) T cells are currently standard treatment options for patients with relapsed or refr...
Curtis Marcoux,Partow Kebriaei
Curtis Marcoux
Allogeneic hematopoietic stem cell transplantation (allo-HCT) remains a cornerstone in the treatment of high-risk acute lymphoblastic leukemia (ALL), yet optimal patient selection is challenging in the era of rapidly changing modern therapy...
T-cell-based therapies for treating relapsed or refractory mantle cell lymphoma [0.03%]
基于T细胞的疗法治疗复发或难治性套细胞淋巴瘤
Zachary D Epstein-Peterson,M Lia Palomba
Zachary D Epstein-Peterson
While targeted therapies such as Bruton's tyrosine kinase and BCL2 inhibitors have fundamentally changed the treatment of mantle cell lymphoma (MCL), not all patients respond to these therapies, and responses are finite and can be fleeting,...
Alexandra Borst
Alexandra Borst
The last 2 decades of genetic discovery in the field of vascular anomalies have brought targeted medical therapies to the forefront of care patients with vascular anomalies and have broadened the role of hematologists/oncologists in this fi...
M Teresa Cibeira,Luis Gerardo Rodríguez-Lobato,Aida Alejaldre et al.
M Teresa Cibeira et al.
Monoclonal gammopathy of undetermined significance (MGUS) is a highly prevalent disorder characterized by a small bone marrow plasma cell or lymphoplasmacytic clone (less than 10%) that produces a small amount of monoclonal paraprotein with...
Michele P Lambert
Michele P Lambert
Treatment of immune thrombocytopenia (ITP) has evolved over the last 20 years in response to our increased understanding of the pathophysiology of this complex immune disorder. New treatments in development have taken advantage of our evolv...
Maureen Baldwin,Kristina M Haley,Janice M Staber
Maureen Baldwin
Heavy menstrual bleeding (HMB) is a common symptom in adolescence, often leading to significant disruptions in daily life, such as school absences, shame caused by the stigma surrounding menstruation, and symptoms from iron deficiency. Furt...