Liver xenotransplantation: Progress, mechanistic barriers and strategies for clinical translation [0.03%]
肝脏异种移植：进展、机制障碍及临床转化策略
Yuan-Yi Mang,Muhammad Ameen Jamal,Yu-Jie Liu et al.
Yuan-Yi Mang et al.
Pig-to-human liver xenotransplantation holds promise for alleviating the severe shortage of human donor livers. In recent years, China has achieved milestone progress in this field. Livers from gene-edited pigs have been successfully transp...
Modulating hepatic stellate cell senescence: A promising therapeutic strategy for liver fibrosis [0.03%]
调节肝星状细胞衰老：抗肝纤维化治疗的新策略
Muthusethupathi Sharmila,Karthik Shree Harini,Devaraj Ezhilarasan
Muthusethupathi Sharmila
Fibrosis is characterized by the abnormal deposition of extracellular matrix (ECM) components in liver tissue following chronic liver injury, ultimately leading to hepatic cirrhosis. Following liver damage, hepatic stellate cells (HSCs) und...
Tripartite motif-containing 67 promotes progression of hepatocellular carcinoma by regulating MAPK signaling pathway [0.03%]
三聚体 motives 含有的 67 通过调节 MAPK 信号通路促进肝细胞癌的发展进展
Zhuang Zhou,Shi-Yi Zhang,Ying-Song Jiang et al.
Zhuang Zhou et al.
Background: Hepatocellular carcinoma (HCC) remains a significant health concern, given its rising incidence and the increasing complexity associated with its management. The exploration of novel intervention approaches, p...
Proximal splenic artery ligation improves liver reperfusion, mitigates graft injury and decreases complications after liver transplantation [0.03%]
近端脾动脉结扎可改善肝移植再灌注质量、减轻移植物损伤和术后并发症
Zhao-Yi Wu,Neng-Sheng Fu,Yu-Jun Ji et al.
Zhao-Yi Wu et al.
Background: Graft restoration after liver transplantation (LT) critically depends on adequate hepatic arterial blood flow. Splenic artery ligation (SAL) demonstrates flow-enhancing effects, though its safety and efficacy ...
Is the 0.80% graft-to-recipient weight threshold still relevant in modern adult living donor liver transplantation? [0.03%]
在现代成人活体肝移植中，80%的移植物受体体重阈值仍具有相关性吗？
Dimitri A Raptis,Leen Alshibi,Sami A Kareem et al.
Dimitri A Raptis et al.
The graft-to-recipient weight ratio (GRWR) threshold of 0.80% has long been used to guide graft selection in adult living donor liver transplantation (LDLT) as a pragmatic surrogate for graft adequacy. However, expanding use of donor-sparin...
Yi-Heng Jiang,Wei Yu,Lin-Yan Zeng et al.
Yi-Heng Jiang et al.
Exosomal hnRNPA2B1 suppresses irinotecan-induced ferroptosis in pancreatic cancer [0.03%]
外泌体hnRNPA2B1通过抑制铁死亡诱导的胰腺癌细胞凋亡
Xu-Lin Zhou,Wei Liu,Xiao-Chun Sun et al.
Xu-Lin Zhou et al.
Background: Irinotecan is a commonly used chemotherapeutic drug for pancreatic cancer (PC), but its specific mechanism of inducing cell death is yet to be elucidated. Exosomes are key mediators of intercellular communicat...
Machine learning-driven prognostication in liver transplantation: A tacrolimus intrapatient variability enhanced predictive model [0.03%]
基于 Tacrolimus 患者内变异性的机器学习驱动的肝脏移植预后预测模型
Yao-Xing Ren,Yan Wang,Jun-Xi Xiang et al.
Yao-Xing Ren et al.
Background: Accurately predicting long-term survival after liver transplantation (LT) remains a major clinical challenge. Tacrolimus intrapatient variability (Tac-IPV) has emerged as a potential prognostic marker, yet its...
Jan P Lerut,Samuele Iesari
Jan P Lerut
Robotic surgery in liver transplantation: Current status and perspectives from living and deceased donor settings [0.03%]
机器人手术在肝移植中的现状及活体供肝和尸体供肝的前景分析
Cristiano Guidetti,Roberta Odorizzi,Barbara Catellani et al.
Cristiano Guidetti et al.
Background: Robotic surgery has progressively expanded its role in hepatopancreatobiliary surgery, and its application to liver transplantation represents one of the most advanced developments in minimally invasive surger...