Family-based exome-sequencing approach identifies rare susceptibility variants for lithium-responsive bipolar disorder [0.03%]
基于家系的外显子组测序识别出罕见的情绪障碍易感变异
Cristiana Cruceanu,Amirthagowri Ambalavanan,Dan Spiegelman et al.
Cristiana Cruceanu et al.
Bipolar disorder (BD) is a psychiatric condition characterized by the occurrence of at least two episodes of clinically disturbed mood including mania and depression. A vast literature describing BD studies suggests that a strong genetic co...
Public attitudes towards genomic risk profiling as a component of routine population screening [0.03%]
公众对基因组风险评估作为常规人口筛查组成部分的态度研究
S G Nicholls,B J Wilson,S M Craigie et al.
S G Nicholls et al.
Including low penetrance genomic variants in population-based screening might enable personalization of screening intensity and follow up. The application of genomics in this way requires formal evaluation. Even if clinically beneficial, up...
Neuregulin 1-alpha regulates phosphorylation, acetylation, and alternative splicing in lymphoblastoid cells [0.03%]
神经调节素1-α调控淋巴母细胞系中的磷酸化、乙酰化和选择性剪接事件
Mohammad M Ghahramani Seno,Fuad G Gwadry,Pingzhao Hu et al.
Mohammad M Ghahramani Seno et al.
Neuregulins (NRGs) are signaling molecules involved in various cellular and developmental processes. Abnormal expression and (or) genomic variations of some of these molecules, such as NRG1, have been associated with disease conditions such...
Microbial community and potential functional gene diversity involved in anaerobic hydrocarbon degradation and methanogenesis in an oil sands tailings pond [0.03%]
油砂尾矿坝中参与厌氧烃类降解和产甲烷的微生物群落及潜在功能基因多样性
Dongshan An,Damon Brown,Indranil Chatterjee et al.
Dongshan An et al.
Oil sands tailings ponds harbor large amounts of tailings resulting from surface mining of bitumen and consist of water, sand, clays, residual bitumen, and hydrocarbon diluent. Oxygen ingress in these ponds is limited to the surface layers,...
Metagenomic analysis of an anaerobic alkane-degrading microbial culture: potential hydrocarbon-activating pathways and inferred roles of community members [0.03%]
无氧烷烃降解微生物群落的元基因组分析：潜在的烃活化途径及成员作用预测
Boonfei Tan,Xiaoli Dong,Christoph W Sensen et al.
Boonfei Tan et al.
A microbial community (short-chain alkane-degrading culture, SCADC) enriched from an oil sands tailings pond was shown to degrade C6-C10 alkanes under methanogenic conditions. Total genomic DNA from SCADC was subjected to 454 pyrosequencing...
Whole genome sequencing of Gir cattle for identifying polymorphisms and loci under selection [0.03%]
奶牛全基因组测序以鉴定多态性和选择性位点
Xiaoping Liao,Fred Peng,Selma Forni et al.
Xiaoping Liao et al.
Genetic variation in Gir cattle (Bos indicus) has so far not been well characterized. In this study, we used whole genome sequencing of three Gir bulls and a pooled sample from another 11 bulls to identify polymorphisms and loci under selec...
Association analysis for feed efficiency traits in beef cattle using preserved haplotypes [0.03%]
基于保育型单倍体的肉牛饲料报酬性状关联分析
Duc Lu,Mehdi Sargolzaei,Changxi Li et al.
Duc Lu et al.
This study reports a genome wide scan for chromosome regions and their haplotypes that significantly associated with average daily gain (ADG), dry matter intake (DMI), and residual feed intake (RFI) in beef cattle. The study used data from ...
Effects of introgression on the genetic population structure of two ecologically and economically important conifer species: lodgepole pine (Pinus contorta var. latifolia) and jack pine (Pinus banksiana) [0.03%]
渐渗对两种生态和经济上重要的冷杉属物种（黑松（Pinus contorta var. latifolia）和杰克松（Pinus banksiana））的遗传种群结构的影响
Catherine I Cullingham,Janice E K Cooke,David W Coltman
Catherine I Cullingham
Forest trees exhibit a remarkable range of adaptations to their environment, but as a result of frequent and long-distance gene flow, populations are often only weakly differentiated. Lodgepole and jack pine hybridize in western Canada, whi...
The impact of a moderate chronic temperature increase on spleen immune-relevant gene transcription depends on whether Atlantic cod (Gadus morhua) are stimulated with bacterial versus viral antigens [0.03%]
中等慢性温度升高对大西洋 cod(Gadus morhua)免疫相关基因转录的影响取决于细菌和病毒抗原的刺激
Tiago S Hori,A Kurt Gamperl,Gord Nash et al.
Tiago S Hori et al.
Exposure to elevated temperature is an inherent feature of Atlantic cod (Gadus morhua) sea-cage culture in some regions (e.g., Newfoundland) and may also become an increasingly prevalent challenge for wild fish populations because of accele...
Jagjit S Ludu,Graham S Plastow
Jagjit S Ludu
The emergence of the middle class in countries such as Brazil, Russia, India, and China is resulting in increasing global demand for animal-based food products. This increase represents a unique opportunity for Canadian livestock producers ...