Reflections on the organization and the physical state of chromatin in eukaryotic cells [0.03%]
论真核细胞染色质的组织和物理状态
Hilmar Strickfaden
Hilmar Strickfaden
In recent years, our perception of chromatin structure and organization in the cell nucleus has changed in fundamental ways. The 30 nm chromatin fiber has lost its status as an essential in vivo structure. Hi-C and related biochemical metho...
Dongbo Ding,Thi Thuy Nguyen,Matthew Y H Pang et al.
Dongbo Ding et al.
Canonical histones (H2A, H2B, H3, and H4) are present in all eukaryotes where they package genomic DNA and participate in numerous cellular processes, such as transcription regulation and DNA repair. In addition to the canonical histones, t...
The neonicotinoid insecticide thiamethoxam enhances expression of stress-response genes in Zea mays in an environmentally specific pattern [0.03%]
新烟碱类杀虫剂噻虫嗪以环境依赖的方式增强玉米应激反应基因的表达
Megan A House,Clarence J Swanton,Lewis N Lukens
Megan A House
Recent studies indicate that thiamethoxam (TMX), a neonicotinoid insecticide, can affect plant responses to environmental stressors, such as neighboring weeds. The molecular mechanisms behind both stable and environmentally specific respons...
Tasnim H Beacon,James R Davie
Tasnim H Beacon
The chicken model organism has advanced the areas of developmental biology, virology, immunology, oncology, epigenetic regulation of gene expression, conservation biology, and genomics of domestication. Further, the chicken model organism h...
Ritesh Krishna,Vadim Elisseev
Ritesh Krishna
Genomics is both a data- and compute-intensive discipline. The success of genomics depends on an adequate informatics infrastructure that can address growing data demands and enable a diverse range of resource-intensive computational activi...
Genes underlying species differences in cuticular hydrocarbon production between Drosophila melanogaster and D. simulans [0.03%]
参与果蝇Drosophila melanogaster和Drosophila simulans表皮烃类生产的基因及其差异分析研究
Heather K E Ward,Amanda J Moehring
Heather K E Ward
Surface chemical compounds are key components of survival and reproduction in many species. Cuticular hydrocarbons (CHCs) are chemical compounds produced by all insects that are used for both desiccation resistance and chemical communicatio...
The treatment of SARS-CoV2 with antivirals and mitigation of the cytokine storm syndrome: the role of gene expression [0.03%]
抗病毒药物治疗SARS-CoV2和减轻细胞因子风暴综合征的作用：基因表达的作用
Wenxia Luo,Olufola O Ige,Tasnim H Beacon et al.
Wenxia Luo et al.
In the absence of a vaccine, the treatment of SARS-CoV2 has focused on eliminating the virus with antivirals or mitigating the cytokine storm syndrome (CSS) that leads to the most common cause of death: respiratory failure. Herein we discus...
The genetics of Cannabis-genomic variations of key synthases and their effect on cannabinoid content [0.03%]
大麻的遗传学：关键合成酶的基因组变异及其对大麻素含量的影响
Aparna Singh,Andriy Bilichak,Igor Kovalchuk
Aparna Singh
Despite being a controversial crop, Cannabis sativa L. has a long history of cultivation throughout the world. Following recent legalization in Canada, Cannabis is emerging as an important plant for both medicinal and recreational purposes....
Environmental DNA detection of endangered and invasive species in Kejimkujik National Park and Historic Site [0.03%]
利用环境DNA检测基米库吉国家公园和历史遗址中的濒危及入侵物种
Tzitziki Loeza-Quintana,Steven Crookes,Pei Yuan Li et al.
Tzitziki Loeza-Quintana et al.
The use of environmental DNA (eDNA) allows the early detection of aquatic species at low densities (e.g., elusive and invasive species), which otherwise could be challenging to monitor using conventional techniques. Here, we assess the abil...
Determination of reverse transcriptase inhibitor resistance mutations in HIV-1 infected children in Côte d'Ivoire [0.03%]
科特迪瓦感染HIV-1儿童中逆转录酶抑制剂耐药突变的判定
Massara Camara-Cisse,Youzan Ferdinad Djohan,Thomas d&#x;Aquin Toni et al.
Massara Camara-Cisse et al.
Treatment scale-up is leading to a progressive increase in HIV resistance to antiretrovirals, especially in children. To assess resistance to reverse transcriptase inhibitors (RTIs) in HIV-1 infected children in Côte d'Ivoire, genotypic re...