In silico toxicology models and databases as FDA Critical Path Initiative toolkits [0.03%]
基于计算机的毒理学模型和数据库可作为美国食品药品管理局关键路径行动计划工具包
Luis G Valerio Jr
Luis G Valerio Jr
In silico toxicology methods are practical, evidence-based and high throughput, with varying accuracy. In silico approaches are of keen interest, not only to scientists in the private sector and to academic researchers worldwide, but also t...
Eneritz Agirre,Eduardo Eyras
Eneritz Agirre
Recent advances in high-throughput sequencing have facilitated the genome-wide studies of small non-coding RNAs (sRNAs). Numerous studies have highlighted the role of various classes of sRNAs at different levels of gene regulation and disea...
The human fatty acid-binding protein family: evolutionary divergences and functions [0.03%]
人类脂质结合蛋白家族：进化分歧及功能研究
Rebecca L Smathers,Dennis R Petersen
Rebecca L Smathers
Fatty acid-binding proteins (FABPs) are members of the intracellular lipid-binding protein (iLBP) family and are involved in reversibly binding intracellular hydrophobic ligands and trafficking them throughout cellular compartments, includi...
Mirella Filocamo,Amelia Morrone
Mirella Filocamo
Lysosomal storage disorders (LSDs) are a large group of more than 50 different inherited metabolic diseases which, in the great majority of cases, result from the defective function of specific lysosomal enzymes and, in few cases, of non-en...
Difficulties in finding DNA mutations and associated phenotypic data in web resources using simple, uncomplicated search terms, and a suggested solution [0.03%]
使用简单的、不复杂的搜索词在网页资源中查找DNA突变及其相关表型数据的困难及解决方案建议
Elizabeth A Webb,Timothy D Smith,Richard G H Cotton
Elizabeth A Webb
DNA mutation data currently reside in many online databases, which differ markedly in the terminology used to describe or define the mutation and also in completeness of content, potentially making it difficult both to locate a mutation of ...
Comparative Study
Human genomics. 2011 Mar;5(3):141-55. DOI:10.1186/1479-7364-5-3-141 2011
Vasilis Vasiliou
Vasilis Vasiliou
Mary Shimoyama,Jennifer R Smith,Tom Hayman et al.
Mary Shimoyama et al.
The Rat Genome Database (RGD) (http://rgd.mcw.edu) provides a comprehensive platform for comparative genomics and genetics research. RGD houses gene, QTL and polymorphic marker data for rat, mouse and human and provides easy access to data ...
Comparative Study
Human genomics. 2011 Jan;5(2):124-9. DOI:10.1186/1479-7364-5-2-124 2011
Hyunmin Kim,Jihye Kim,Heather Selby et al.
Hyunmin Kim et al.
Chromatin immunoprecipitation followed by massively parallel next-generation sequencing (ChIP-seq) is a valuable experimental strategy for assaying protein-DNA interaction over the whole genome. Many computational tools have been designed t...
Transient receptor potential (TRP) gene superfamily encoding cation channels [0.03%]
瞬时受体电位(TRP)通道基因超家族
Zan Pan,Hua Yang,Peter S Reinach
Zan Pan
Transient receptor potential (TRP) non-selective cation channels constitute a superfamily, which contains 28 different genes. In mammals, this superfamily is divided into six subfamilies based on differences in amino acid sequence homology ...
Exploring the potential relevance of human-specific genes to complex disease [0.03%]
探究人类特有基因与复杂疾病的相关性
David N Cooper,Hildegard Kehrer-Sawatzki
David N Cooper
Although human disease genes generally tend to be evolutionarily more ancient than non-disease genes, complex disease genes appear to be represented more frequently than Mendelian disease genes among genes of more recent evolutionary origin...