Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily [0.03%]
人secretoglobin（SCGB）基因超家族的更新及小鼠Scgb基因超家族中androgen-结合蛋白基因“进化繁盛”的例子
Brian C Jackson,David C Thompson,Mathew W Wright et al.
Brian C Jackson et al.
The secretoglobins (SCGBs) comprise a family of small, secreted proteins found in animals exclusively of mammalian lineage. There are 11 human SCGB genes and five pseudogenes. Interestingly, mice have 68 Scgb genes, four of which are highly...
Neurofibromatosis type 1-associated tumours: their somatic mutational spectrum and pathogenesis [0.03%]
神经纤维瘤病Ⅰ型相关肿瘤及其体细胞突变光谱和发病机制
Sebastian Laycock-van Spyk,Nick Thomas,David N Cooper et al.
Sebastian Laycock-van Spyk et al.
Somatic gene mutations constitute key events in the malignant transformation of human cells. Somatic mutation can either actively speed up the growth of tumour cells or relax the growth constraints normally imposed upon them, thereby confer...
Human genetics and genomics a decade after the release of the draft sequence of the human genome [0.03%]
人类基因组草图公布后的十年间的人类遗传学和基因组学
Nasheen Naidoo,Yudi Pawitan,Richie Soong et al.
Nasheen Naidoo et al.
Substantial progress has been made in human genetics and genomics research over the past ten years since the publication of the draft sequence of the human genome in 2001. Findings emanating directly from the Human Genome Project, together ...
The role of ALDH2 and ADH1B polymorphism in alcohol consumption and stroke in Han Chinese [0.03%]
ALDH2和ADH1B多态性在中国汉族人饮酒及脑卒中发生中的作用研究
Chung-Tay Yao,Chun-An Cheng,Hsu-Kun Wang et al.
Chung-Tay Yao et al.
The genes encoding the enzymes for metabolising alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2) - exhibit genetic polymorphism and ethnic variations. Although the ALDH2*2 variant allele has been widely accepted as prot...
Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration [0.03%]
系统生物学分析揭示了维生素D代谢在年龄相关性黄斑变性疾病发生发展中的新作用
Margaux A Morrison,Alexandra C Silveira,Nancy Huynh et al.
Margaux A Morrison et al.
Vitamin D has been shown to have anti-angiogenic properties and to play a protective role in several types of cancer, including breast, prostate and cutaneous melanoma. Similarly, vitamin D levels have been shown to be protective for risk o...
Comparative Study
Human genomics. 2011 Oct;5(6):538-68. DOI:10.1186/1479-7364-5-6-538 2011
Role of CYP2E1 genotypes in susceptibility to colorectal cancer in the Kashmiri population [0.03%]
CYP2E1基因多态性在喀什米尔人群结直肠癌易感性中的作用研究
A Syed Sameer,Saniya Nissar,Qurteeba Qadri et al.
A Syed Sameer et al.
Cytochrome P450 2E1 (CYP2E1) is a key enzyme involved in the metabolic activation of procarcinogens such as N-nitrosoamines and low-molecular-weight organic compounds. The main aim of this study was to determine whether CYP450 2E1 polymorph...
Comparative Study
Human genomics. 2011 Oct;5(6):530-7. DOI:10.1186/1479-7364-5-6-530 2011
J Mark Petrash,Philip A Ruzycki,Gregory J Zablocki
J Mark Petrash
e-PKGene: a knowledge-based research tool for analysing the impact of genetics on drug exposure [0.03%]
e-PKGene：一个基于知识的针对遗传因素对药物作用影响的研究工具
Houda Hachad,Casey Lynnette Overby,Sophie Argon et al.
Houda Hachad et al.
e-PKGene (www.pharmacogeneticsinfo.org) is a manually curated knowledge product developed in the Department of Pharmaceutics at the University of Washington, USA. The tool integrates information from the literature, public repositories, ref...
Survey of public domain software for docking simulations and virtual screening [0.03%]
对接模拟和虚拟筛选的公共领域软件调查
Jacek Biesiada,Aleksey Porollo,Prakash Velayutham et al.
Jacek Biesiada et al.
Progress in functional genomics and structural studies on biological macromolecules are generating a growing number of potential targets for therapeutics, adding to the importance of computational approaches for small molecule docking and v...
Athanassios Vassilopoulos,Kristofer S Fritz,Dennis R Petersen et al.
Athanassios Vassilopoulos et al.
The sirtuin family of proteins is categorised as class III histone deacetylases that play complex and important roles in ageing-related pathological conditions such as cancer and the deregulation of metabolism. There are seven members in hu...