Gene selection and cancer type classification of diffuse large-B-cell lymphoma using a bivariate mixture model for two-species data [0.03%]
基于二元混合模型的弥漫性大B细胞淋巴瘤基因选择及肿瘤类型分类研究
Yuhua Su,Dahlia Nielsen,Lei Zhu et al.
Yuhua Su et al.
: A bivariate mixture model utilizing information across two species was proposed to solve the fundamental problem of identifying differentially expressed genes in microarray experiments. The model utility was illustrated using a dog and hu...
Yushi Liu,Toru Nyunoya,Shuguang Leng et al.
Yushi Liu et al.
The estimation of genetic ancestry in human populations has important applications in medical genetic studies. Genetic ancestry is used to control for population stratification in genetic association studies, and is used to understand the g...
CXCL5 polymorphisms are associated with variable blood pressure in cardiovascular disease-free adults [0.03%]
CXC基序配体5基因多态性与无心血管疾病的成人血压变异相关
Amber L Beitelshees,Christina L Aquilante,Hooman Allayee et al.
Amber L Beitelshees et al.
Objective: Leukocyte count has been associated with blood pressure, hypertension, and hypertensive complications. We hypothesized that polymorphisms in the CXCL5 gene, which encodes the neutrophilic chemokine ENA-78, are ...
Local sequence determinants of two in-frame triplet deletion/duplication hotspots in the RHD/RHCE genes [0.03%]
Rh基因(RHD/RHCE)两个三联体缺失/重复热点区域的序列决定因素
Jian-Min Chen,David N Cooper,Claude Férec
Jian-Min Chen
GWIDD: a comprehensive resource for genome-wide structural modeling of protein-protein interactions [0.03%]
GWIDD：一个关于蛋白质-蛋白质相互作用的全基因组结构模型综合资源
Petras J Kundrotas,Zhengwei Zhu,Ilya A Vakser
Petras J Kundrotas
Protein-protein interactions are a key component of life processes. The knowledge of the three-dimensional structure of these interactions is important for understanding protein function. Genome-Wide Docking Database (http://gwidd.bioinform...
James J Galligan,Dennis R Petersen
James J Galligan
Enzyme-mediated disulfide bond formation is a highly conserved process affecting over one-third of all eukaryotic proteins. The enzymes primarily responsible for facilitating thiol-disulfide exchange are members of an expanding family of pr...
SNPTrack™ : an integrated bioinformatics system for genetic association studies [0.03%]
SNPTrack：遗传关联研究的生物信息学集成系统
Joshua Xu,Reagan Kelly,Guangxu Zhou et al.
Joshua Xu et al.
A genetic association study is a complicated process that involves collecting phenotypic data, generating genotypic data, analyzing associations between genotypic and phenotypic data, and interpreting genetic biomarkers identified. SNPTrack...
Louise C Daugherty,Ruth L Seal,Mathew W Wright et al.
Louise C Daugherty et al.
The HUGO Gene Nomenclature Committee (HGNC) assigns approved gene symbols to human loci. There are currently over 33,000 approved gene symbols, the majority of which represent protein-coding genes, but we also name other locus types such as...
Mitochondrial and nuclear genomics and the emergence of personalized medicine [0.03%]
线粒体和核基因组学与个性化医疗的兴起
Ryan L Parr,Luis H Martin
Ryan L Parr
Developing early detection biosensors for disease has been the long‒held goal of the Human Genome Project, but with little success. Conversely, the biological properties of the mitochondrion coupled with the relative simplicity of the mito...
Estimating ancestral proportions in a multi-ethnic US sample: implications for studies of admixed populations [0.03%]
估计多民族美国样本的祖先比例：对混血人群研究的意义
Orna Levran,Olaoluwakitan Awolesi,Pei-Hong Shen et al.
Orna Levran et al.
This study was designed to determine the ancestral composition of a multi-ethnic sample collected for studies of drug addictions in New York City and Las Vegas, and to examine the reliability of self-identified ethnicity and three-generatio...
Multicenter Study
Human genomics. 2012 Jul 5;6(1):2. DOI:10.1186/1479-7364-6-2 2012