Bajinder S Dhanoa,Tiziana Cogliati,Akhila G Satish et al.
Bajinder S Dhanoa et al.
The Kelch-like (KLHL) gene family encodes a group of proteins that generally possess a BTB/POZ domain, a BACK domain, and five to six Kelch motifs. BTB domains facilitate protein binding and dimerization. The BACK domain has no known functi...
Vive la différence: naming structural variants in the human reference genome [0.03%]
发扬不同：人类参考基因组结构变异命名法
Ruth L Seal,Mathew W Wright,Kristian A Gray et al.
Ruth L Seal et al.
The HUGO Gene Nomenclature Committee has approved gene symbols for the majority of protein-coding genes on the human reference genome. To adequately represent regions of complex structural variation, the Genome Reference Consortium now incl...
Salamander Hox clusters contain repetitive DNA and expanded non-coding regions: a typical Hox structure for non-mammalian tetrapod vertebrates? [0.03%]
有尾类动物HOX簇包含重复DNA和扩增的非编码区：非哺乳纲四足脊椎动物典型的HOX结构？
Stephen Randal Voss,Srikrishna Putta,John A Walker et al.
Stephen Randal Voss et al.
Hox genes encode transcription factors that regulate embryonic and post-embryonic developmental processes. The expression of Hox genes is regulated in part by the tight, spatial arrangement of conserved coding and non-coding sequences. The ...
Genetic effects of ATP1A2 in familial hemiplegic migraine type II and animal models [0.03%]
ATP1A2基因在家族性半侧瘫痪型偏头痛Ⅱ型和动物模型中的遗传效应
Stephanie M Gritz,Richard A Radcliffe
Stephanie M Gritz
Na(+)/K(+)-ATPase alpha 2 (Atp1a2) is an integral plasma membrane protein belonging to the P-type ATPase family that is responsible for maintaining the sodium (Na(+)) and potassium (K(+)) gradients across cellular membranes with hydrolysis ...
Exome sequencing identifies nonsegregating nonsense ATM and PALB2 variants in familial pancreatic cancer [0.03%]
全外显子组测序鉴定出了非重组型ATM及PALB2错义突变在家族性胰腺癌中的作用
Robert C Grant,Wigdan Al-Sukhni,Ayelet E Borgida et al.
Robert C Grant et al.
We sequenced 11 germline exomes from five families with familial pancreatic cancer (FPC). One proband had a germline nonsense variant in ATM with somatic loss of the variant allele. Another proband had a nonsense variant in PALB2 with somat...
Extrapolating the effect of deleterious nsSNPs in the binding adaptability of flavopiridol with CDK7 protein: a molecular dynamics approach [0.03%]
基于分子动力学的负选择非同义单核苷酸多态性对喜树碱衍生物与细胞周期蛋白依赖性激酶7结合适应性影响的研究
C George Priya Doss,N Nagasundaram,Chiranjib Chakraborty et al.
C George Priya Doss et al.
Background: Recent reports suggest the role of nonsynonymous single nucleotide polymorphisms (nsSNPs) in cyclin-dependent kinase 7 (CDK7) gene associated with defect in the DNA repair mechanism that may contribute to canc...
Value that industrial collaborations bring to research and education efforts in universities: perspective of a professor working in the field of development of therapeutic proteins [0.03%]
工业合作对大学研究及教育工作的价值：一位从事药物蛋白开发的教授的观点
John F Carpenter
John F Carpenter
Editorial
Human genomics. 2013 Mar 5;7(1):7. DOI:10.1186/1479-7364-7-7 2013
Development of a cost-effective high-throughput process of microsatellite analysis involving miniaturized multiplexed PCR amplification and automated allele identification [0.03%]
一种低成本的微卫星分析高通量工艺的发展，包括微型化多重PCR扩增和自动化等位基因识别
Truc T M Nguyen,Shaheen E Lakhan,Barry A Finette
Truc T M Nguyen
Background: Microsatellites are nucleotide sequences of tandem repeats occurring throughout the genome, which have been widely used in genetic linkage analysis, studies of loss of heterozygosity, determination of lineage ...
How to create innovation by building the translation bridge from basic research into medicinal drugs: an industrial perspective [0.03%]
从基础研究到药物的转化桥梁建设促进创新工业视角
Paul G Germann,Alexander Schuhmacher,Juan Harrison et al.
Paul G Germann et al.
The global healthcare industry is undergoing substantial changes and adaptations to the constant decline of approved new medical entities. This decrease in internal research productivity is resulting in a major decline of patent-protected s...
The updated RGD Pathway Portal utilizes increased curation efficiency and provides expanded pathway information [0.03%]
更新后的RGD通路门户利用了增强的编辑效率，并提供了扩展的通路信息
G Thomas Hayman,Pushkala Jayaraman,Victoria Petri et al.
G Thomas Hayman et al.
The RGD Pathway Portal provides pathway annotations for rat, human and mouse genes and pathway diagrams and suites, all interconnected via the pathway ontology. Diagram pages present the diagram and description, with diagram objects linked ...