Early mutational events and clonal dynamics in normal crypts: implications for colorectal tumorigenesis [0.03%]
正常隐窝中的早期突变事件和克隆动态及其对结直肠肿瘤发生的意义
Charlie Marvalim,Dedrick Kok Hong Chan
Charlie Marvalim
Genetic insights into 5-LOX-activating protein: a narrative review of disease associations [0.03%]
5-LOX活化蛋白的遗传学见解：疾病关联叙述性综述
Katharina Rataj,Ulrike Garscha
Katharina Rataj
The 5-lipoxygenase-activating protein (FLAP) is an integral membrane protein that is essential for 5-lipoxygenase-mediated leukotriene formation, thereby playing a key role in inflammation and serving as a potential therapeutic target. For ...
Association of MALAT1 gene polymorphisms with neuroblastoma susceptibility in children from Jiangsu Province [0.03%]
江苏省MALAT1基因多态性与儿童神经母细胞瘤易感性的关联分析
Yong Lian,Lili He,Siqi Dong et al.
Yong Lian et al.
Background: Neuroblastoma, a clinically heterogeneous pediatric tumor, has varying outcomes ranging from spontaneous regression to aggressive metastasis. Recent studies have emphasized non-coding RNAs, particularly long n...
Identification of diagnostic and prognostic phospholipid biomarkers in idiopathic pulmonary fibrosis via machine learning and in vivo validation [0.03%]
基于机器学习和体内验证的特发性肺纤维化诊断及预后磷脂标志物鉴定
Liqing Yang,Lian Liu,Yi Liao et al.
Liqing Yang et al.
Background: Idiopathic pulmonary fibrosis (IPF) is a type of progressive interstitial lung disease with an unclear cause and generally poor prognosis. Phospholipids have been implicated in IPF, motivating this investigati...
Genetically predicted the causal relationship between gut-brain axis and chronic pain: a Mendelian randomization study [0.03%]
遗传预测的肠-脑轴与慢性疼痛的因果关系：一项孟德尔随机化研究
Shaopeng Shi,Xinyu Zhou,Chunxiang Ma et al.
Shaopeng Shi et al.
Genetic screening for hearing loss of 38,589 neonates with follow-up in South China [0.03%]
华南38,589名新生儿听力丧失基因筛查及随访研究
Xia Gu,Runzhong Huang,Jie Xie et al.
Xia Gu et al.
Background: Hearing loss (HL) is a prevalent disease in children, and conventional neonatal hearing screening has a limited effect. The objective of this study was to analyze the frequency of frequent deafness-associated ...
Recurrent somatic copy number alterations in resected cerebral cavernous malformations [0.03%]
可手术脑海绵状血管畸形的复发性体细胞拷贝数改变
Andrew K Ressler,Evon Debose-Scarlett,Amanda Fuenzalida et al.
Andrew K Ressler et al.
Cerebral Cavernous Malformations (CCMs) are brain vascular lesions that occur in sporadic or inherited (autosomal dominant) forms. The malformations are driven by mutations in KRIT1, CCM2, PDCD10 or MAP3K3. Known oncogenic variants in PIK3C...
Multi-omics and comprehensive multi-trait analysis identify shared genetic etiology of heart failure and related cancers [0.03%]
多组学和综合多性状分析识别出心力衰竭及相关癌症的共享遗传病因
Wen Shui,Xianzhen Wu,Huiping Liu et al.
Wen Shui et al.
From bulk RNA sequencing to spatial transcriptomics: a comparative review of differential gene expression analysis methods [0.03%]
从RNA测序到空间转录组学：差异基因表达分析方法的比较综述
Maryam Kalantari-Dehaghi,Neda Ghohabi-Esfahani,Modjtaba Emadi-Baygi
Maryam Kalantari-Dehaghi
Genome-wide methylation profiles of primary and matched distant metastasis: insights from the Dutch Early-Stage melanoma (D-ESMEL) study [0.03%]
荷兰早期期黑色素瘤(D-ESMEL)研究中的基因组范围甲基化谱：原发灶及其匹配的远处转移灶的启示
Jasper Ouwerkerk,Thamila Kerkour,Antien Mooyaart et al.
Jasper Ouwerkerk et al.
Background: Early-stage (stage I-II) cutaneous melanoma accounts for the majority of melanoma diagnoses. However, more than 40% of patients who die due to melanoma were initially diagnosed with an early-stage melanoma. Th...