Genomic and transcriptomic data reveal molecular differences between homologous recombination deficiency subgroups in Chinese ovarian cancer patients [0.03%]
基因组和转录组图谱揭示中国卵巢癌患者同源重组缺陷亚型的分子特征差异
Hongxia Wang,Wenhong Zhao,Wenhao Zhou et al.
Hongxia Wang et al.
Background: Ovarian cancer (OV) has the highest mortality rate among gynecological cancers and shows varied responses to chemotherapy combined with PARP inhibitors based on homologous recombination deficiency (HRD) subtyp...
DNA methylation in adaptation to high-altitude environments and pathogenesis of related diseases [0.03%]
DNA 甲基化在高海拔环境适应及相关疾病发生发展中的作用机制研究
Xingkai Zhang,Yuxi Yang,Qinghai Shi
Xingkai Zhang
High-altitude environments, characterized by hypoxia, low temperatures, and intense ultraviolet radiation, pose significant challenges to human physiology and health. DNA methylation, as a key epigenetic regulatory mechanism, plays a centra...
Multi-omics signature of healthy versus unhealthy lifestyles reveals associations with diseases [0.03%]
多组学健康与不健康生活方式标志物的特征及其与疾病的关系
Grace Fu,Blake R Rushing,Lee Graves et al.
Grace Fu et al.
This multi-omics cross-sectional study investigated differences in metabolomics, proteomics, and epigenomics profiles between two groups of adults matched for age but differing in lifestyle factors such as body composition, diet, and physic...
Integrative single-cell and bulk transcriptomic analysis reveals the landscape of T cell mitotic catastrophe associated genes in esophageal squamous cell carcinoma [0.03%]
整合单细胞和批量转录组分析揭示食管鳞癌T细胞有丝分裂 catastrophe相关基因的图谱
Shuang Li,Zheng Tao,Nan Wang et al.
Shuang Li et al.
Background: Mitotic catastrophe (MC) is a well-recognized endogenous mechanism of tumor cell death, characterized as a delayed cell death process associated with aberrant mitosis. However, its prognostic significance in t...
Comparative outcome and prognostic factor analysis among MDS/AML patients with TP53 mutations, snps, and wild type [0.03%]
TP53突变、单核苷酸多态性及野生型基因在MDS/AML患者中的预后因素分析及疗效比较
Xiaodi Yang,Zeyin Liang,Li Ji et al.
Xiaodi Yang et al.
While variant TP53 is an adverse prognosis factor in myelodysplastic syndromes (MDS)/acute myeloid leukemia (AML), current clinical prognosis and variation feature analysis of TP53 alterations remain limited. We evaluated 333 MDS/AML patien...
Increasing pathogenic germline variant diagnosis rates in precision medicine: current best practices and future opportunities [0.03%]
精准医学中提高致病性生殖系变异诊断率：当前最佳实践和未来机遇
Sonam Dukda,Manoharan Kumar,Andrew Calcino et al.
Sonam Dukda et al.
The accurate diagnosis of pathogenic variants is essential for effective clinical decision making within precision medicine programs. Despite significant advances in both the quality and quantity of molecular patient data, diagnostic rates ...
Clinical and prognostic significance of m6A hypomethylation and IGF2BP3 overexpression in gastric cancer: an integrated epigenomic-transcriptomic analysis [0.03%]
胃癌中m6A低甲基化和IGF2BP3过表达的临床及预后意义：整合表观基因组-转录组分析
Xiangchen Hu,Zhe Wang,Youwei Kou et al.
Xiangchen Hu et al.
Background: Gastric cancer (GC) ranks as the fifth most prevalent malignancy and the third leading cause of cancer-related mortality worldwide, with complex pathogenesis driven by genetic and epigenetic alterations. While...
Flu-CNN: identifying host specificity of Influenza A virus using convolutional networks [0.03%]
利用卷积网络识别流感病毒的宿主特异性 Flu-CNN
Mingda Hu,Nan Luo,Boqian Wang et al.
Mingda Hu et al.
Influenza A viruses (IAVs) have historically posed significant public health threats, causing severe pandemics. Viral host specificity is typically constrained by host barriers, limiting the range of species that can be infected. However, t...
Variants of NLRP genes encoding subcortical maternal complex components are linked to biparental placental mesenchymal dysplasia [0.03%]
编码非固醇母系复合体组分的NLRP基因变异与双亲型胎盘间质细胞发育不良相关
Ayaka Murase,Hiroyuki Mishima,Saori Aoki et al.
Ayaka Murase et al.
Background: Placental mesenchymal dysplasia (PMD) is a placental abnormality resembling partial hydatidiform moles without trophoblastic proliferation. Although many PMD cases involve androgenetic/biparental mosaicism or ...
George P Patrinos,Juergen K V Reichardt,Piero Carninci et al.
George P Patrinos et al.