Exploration of neutrophil-associated genes in the prognosis of bladder urothelial carcinoma based on a machine learning and multi-omics data integration framework [0.03%]
基于机器学习和多组学数据集成框架探索中性粒细胞相关基因在膀胱尿路上皮癌预后中的作用
Muya Ran,Xiaoming Chen,Guancheng Xiao et al.
Muya Ran et al.
Genetic contribution to severe COVID-19 in adults under 60 years without major comorbidities in the German National Pandemic Cohort Network (NAPKON) [0.03%]
德国国家大流行病队列网络(NAPKON)中，无严重合并症的60岁以下成人新冠肺炎重症病例的遗传因素贡献率
Ayda Abolhassani,T Madhusankha Alawathurage,Axel Schmidt et al.
Ayda Abolhassani et al.
While genome-wide association studies (GWAS) have linked common genetic variants to COVID-19 susceptibility and severity, rare high-impact variants may also contribute to phenotypic heterogeneity. Inborn errors of type I interferon immunity...
Jenny Ji Hyun Kim,Tyler B Yang,Xinyue Zhang et al.
Jenny Ji Hyun Kim et al.
The interaction between the genome and the exposome is increasingly recognized as central to human health and disease. While exposome research has generally focused on adverse exposures such as pollutants and toxins, the concept of the bene...
APM⁺ macrophages associated with plaque vulnerability via MIF-CD74 signaling: a multi-omics study [0.03%]
与易损斑块相关的APM⁺巨噬细胞通过MIF-CD74信号通路：一项多组学研究
Xiang Xu,Yuanze Li,Siqi Xiang et al.
Xiang Xu et al.
Background: Atherosclerosis (AS) is a chronic vascular disease and the principal cause leading to ischemic cardiomyopathy (ICM). It involves complex metabolic dysregulation beyond the resolution of single-omics. Emerging ...
Charting exposomethics: a roadmap for the ethical foundations of the human exposome project [0.03%]
绘制出表观伦理学：人类暴露组计划的道德基础路线图
Fenna C M Sillé,Myriem Belkadi,Kirsten Koehler et al.
Fenna C M Sillé et al.
Background: The Human Exposome Project (HEP) aims to chart lifelong environmental exposures and their biological consequences, furnishing the environmental counterpart to the genomic revolution. Yet the fine‑grained, mul...
Integrating next-generation sequencing with biochemical screening to optimize first-tier newborn screening systems [0.03%]
整合新一代测序与生化筛选以优化新生儿初步筛查系统
Yifan Yin,Liang Ye,Min Chen et al.
Yifan Yin et al.
Bryony Braschi,Ruth L Seal,Elspeth A Bruford
Bryony Braschi
The HUGO Gene Nomenclature Committee (HGNC) assigns unique symbols and names to human genes and its sister project, the Vertebrate Gene Nomenclature Committee (VGNC), names genes across selected vertebrates (chimp, macaque, horse, cattle, p...
Epimutation analysis reveals involvement of SLIT2/ROBO signaling pathway in painful diabetic neuropathy [0.03%]
表观遗传调控在糖尿病神经病理性疼痛发病机制中的作用及其相关信号通路的研究
Katarzyna Malgorzata Kwiatkowska,Paolo Garagnani,Francesca Ferraresi et al.
Katarzyna Malgorzata Kwiatkowska et al.
Changes in gene function or expression caused by epigenetic modifications may play a role in painful diabetic neuropathy. Two independent cohorts of patients deeply phenotyped for painful diabetic neuropathy underwent whole genome DNA methy...
Molecular mechanisms and therapeutic strategies for the recurrent F9 (c.520 + 13 A > G) variant in hemophilia B [0.03%]
血友病B反复出现F9(c.520+13A>G)变异体的分子机制及治疗策略
Huayang Zhang,Chong Wang,Meixiu Gu et al.
Huayang Zhang et al.
Background: Hemophilia B (HB), an X-linked recessive disorder, results from variants in the coagulation factor IX gene (F9). The F9 c.520 + 13 A > G variant is a recurrent intronic variant in HB patients, accounting for 1...
DNA methylation analysis of the epigenome in oral squamous cell carcinoma [0.03%]
口腔鳞状细胞癌表观基因组DNA甲基化分析
Jun Ma,Yu Huang,Yuxin Bai et al.
Jun Ma et al.
Background: Oral squamous cell carcinoma (OSCC) is one of the most common oral malignancies, which can occur in any part of the mouth and is highly malignant. DNA Methylation is an epigenetic modification of the genome, w...