Human activated protein C variants in a rat model of arterial thrombosis [0.03%]
用人激活蛋白C变异体进行动脉血栓形成的大鼠模型试验
Karl Malm,Björn Arnljots,Björn Dahlbäck
Karl Malm
Background: Activated protein C (APC) inhibits coagulation by degrading activated factor V (FVa) and factor VIII (FVIIIa), protein S (PS) functioning as a cofactor to APC. ...
Clinical factors influencing normalization of prothrombin time after stopping warfarin: a retrospective cohort study [0.03%]
华法林停药后凝血酶原时间正常化的临床影响因素：回顾性队列研究
Sam Schulman,Rajae Elbazi,Michelle Zondag et al.
Sam Schulman et al.
Background: Anticoagulation with warfarin should be stopped 4-6 days before invasive procedures to avoid bleeding complications. Despite this routine, some patients still have high International Normalized Ratio (INR) val...
A new method to determine tissue specific tissue factor thrombomodulin activities: endotoxin and particulate air pollution induced disbalance [0.03%]
一种测定组织特异性组织因子和血栓调节蛋白活性的新方法：内毒素和颗粒状空气污染引起的平衡失调
Kim Frederix,Ingeborg M Kooter,René van Oerle et al.
Kim Frederix et al.
Background: Increase in tissue factor (TF) and loss in thrombomodulin (TM) antigen levels has been described in various inflammatory disorders. The functional consequences of such changes in antigen concentrations in the ...
Prevention and treatment of venous thromboembolism with low-molecular-weight heparins: Clinical implications of the recent European guidelines [0.03%]
低分子肝素预防和治疗静脉血栓栓塞症的临床意义——近期欧洲指南的指导作用
Paolo Prandoni
Paolo Prandoni
Venous thromboembolism (VTE) is an important cause of avoidable morbidity and mortality. However, routine prophylaxis for at-risk patients is underused. Recent guidelines issued by an international consensus group, including the Internation...
Use of rosiglitazone before and after vascular injury in hypercholesterolemic rabbits: Assessment of neointimal formation [0.03%]
罗格列酮在血管损伤前后的应用及其对高胆固醇兔新生内膜形成的影响
Alexandre Alessi,Olímpio Ribeiro França Neto,Paulo Roberto Slud Brofman et al.
Alexandre Alessi et al.
Objectives: To analyse the effects of rosiglitazone administered at different times on neointimal formation in hypercholesterolemic rabbits following vascular injury. ...
Ischemic stroke risk, smoking, and the genetics of inflammation in a biracial population: the stroke prevention in young women study [0.03%]
一项关于年轻女性卒中的族裔研究（SPWS）：炎症遗传学、吸烟和缺血性卒中风险
John W Cole,David W Brown,Wayne H Giles et al.
John W Cole et al.
Background: Although cigarette smoking is a well-established risk factor for vascular disease, the genetic mechanisms that link cigarette smoking to an increased incidence of stroke are not well understood. Genetic variat...
Risk of myocardial infarction and overall mortality in survivors of venous thromboembolism [0.03%]
静脉血栓栓塞幸存者的急性心肌梗死和全因死亡率风险
Consuelo Huerta,Saga Johansson,Mari-Ann Wallander et al.
Consuelo Huerta et al.
Background: Venous thromboembolism (VTE) and thromboembolic arterial diseases are usually considered to be distinct entities, but there is evidence to suggest that these disorders may be linked. The aim of this study was ...
Successful management of acute thromboembolic disease complicated with heparin induced thrombocytopenia type II (HIT II): a case series [0.03%]
成功管理华法林相关性免疫性血小板减少症合并急性肺栓塞病例系列报告
Eva Serasli,Maria Antoniadou,Venetia Tsara et al.
Eva Serasli et al.
Heparin-induced thrombocytopenia type II (HIT II) is a rare immune-mediated complication of heparin. The diagnosis of HIT is considered in patients exposed to heparin, presenting with thrombocytopenia and thrombosis.We present two cases wit...
Venous thromboembolism prevention post neck of femur fractures - does it make a difference? [0.03%]
股骨颈骨折后预防静脉血栓栓塞症的措施有效吗？
Radwane Faroug,Shireesha Konnuru,San S Min et al.
Radwane Faroug et al.
Neck of femur fractures predispose patients to venous thromboembolism (VTE). NICE has issued guideline 46 to reduce this risk through the use of antithrombic agents. We audited our department's VTE practise by reviewing the clinical notes o...
Warfarin dose and INR related to genotypes of CYP2C9 and VKORC1 in patients with myocardial infarction [0.03%]
心肌梗死患者的华法林剂量和INR与CYP2C9和VKORC1基因型相关性研究
Kari Bente Foss Haug,Mohammad N Sharikabad,Marianne K Kringen et al.
Kari Bente Foss Haug et al.
Background: Warfarin treatment has a narrow therapeutic range, requiring meticulous monitoring and dosage titration. Individual dosage requirement has recently partly been explained by genetic variation of the warfarin me...