Cancer metabolism meets systems biology: Pyruvate kinase isoform PKM2 is a metabolic master regulator [0.03%]
癌症代谢与系统生物学：丙酮酸激酶同工酶PKM2是代谢调控大师
Fabian V Filipp
Fabian V Filipp
Pyruvate kinase activity is controlled by a tightly woven regulatory network. The oncofetal isoform of pyruvate kinase (PKM2) is a master regulator of cancer metabolism. PKM2 engages in parallel, feed-forward, positive and negative feedback...
Mapping cancer cell metabolism with(13)C flux analysis: Recent progress and future challenges [0.03%]
用碳同位素示踪法绘制癌细胞代谢图谱：近年进展和未来挑战
Casey Scott Duckwall,Taylor Athanasaw Murphy,Jamey Dale Young
Casey Scott Duckwall
The reprogramming of energy metabolism is emerging as an important molecular hallmark of cancer cells. Recent discoveries linking specific metabolic alterations to cancer development have strengthened the idea that altered metabolism is mor...
Epidermal growth factor receptor mutation in lung adenocarcinoma in India: A single center study [0.03%]
印度肺腺癌表皮生长因子受体突变的单中心研究
Dinesh Chandra Doval,Saud Azam,Ullas Batra et al.
Dinesh Chandra Doval et al.
Background: Adenocarcinoma, a subgroup of non-small cell lung cancer, is the most frequent form occurring in the non-smokers. Mutation in tyrosine kinase domain of epidermal growth factor receptor (EGFR) has been a common...
Effects of maternal dietary exposure to cadmium during pregnancy on mammary cancer risk among female offspring [0.03%]
孕期母体饮食暴露于镉对子代女性乳腺癌风险的影响
Jennifer Davis,Galam Khan,Mary Beth Martin et al.
Jennifer Davis et al.
Background: Since heavy metal cadmium is an endocrine disrupting chemical, we investigated whether maternal exposure to cadmium during the pregnancy alters mammary tumorigenesis among female offspring. ...
Stage-specific analysis of plasma protein profiles in ovarian cancer: Difference in-gel electrophoresis analysis of pooled clinical samples [0.03%]
卵巢癌血浆蛋白质图谱的分期特异性分析及临床标本的差异等电聚焦聚丙烯酰胺凝胶电泳分析
Mark J Bailey,Kristy L Shield-Artin,Karen Oliva et al.
Mark J Bailey et al.
Introduction: Ovarian cancer is the leading cause of death from gynecological cancer. Non-specific symptoms early in disease and the lack of specific biomarkers hinder early diagnosis. Multi-marker blood screening tests h...
Kathleen A Vermeersch,Mark P Styczynski
Kathleen A Vermeersch
The first discovery of metabolic changes in cancer occurred almost a century ago. While the genetic underpinnings of cancer have dominated its study since then, altered metabolism has recently been acknowledged as a key hallmark of cancer a...
Digitoxin induces apoptosis in cancer cells by inhibiting nuclear factor of activated T-cells-driven c-MYC expression [0.03%]
Digitoxin通过抑制活化T细胞核因子驱动的c-MYC表达诱导癌细胞凋亡
Qing Feng Yang,Clifton L Dalgard,Ofer Eidelman et al.
Qing Feng Yang et al.
Background: Cardiac glycosides such as digitoxin have been shown to directly cause apoptotic death of cancer cells both in vitro, and in vivo. However, the mechanism connecting cardiac glycoside action to apoptosis is not...
Targeted agents in non-small cell lung cancer therapy: What is there on the horizon? [0.03%]
非小细胞肺癌治疗的靶向药物：未来展望
Victoria M Villaflor,Ravi Salgia
Victoria M Villaflor
Lung cancer is a heterogeneous group of diseases. There has been much research in lung cancer over the past decade which has advanced our ability to treat these patients with a more personalized approach. The scope of this paper is to revie...
Jennifer M Hanna,Mark W Onaitis
Jennifer M Hanna
Lung cancer is the leading cause of cancer deaths worldwide, and current therapies are disappointing. Elucidation of the cell(s) of origin of lung cancer may lead to new therapeutics. In addition, the discovery of putative cancer-initiating...
Human endogenous retroviral K element encodes fusogenic activity in melanoma cells [0.03%]
人内源性逆转录病毒K族在黑色素瘤细胞中编码融合活性
Gengming Huang,Zhongwu Li,Xiaohua Wan et al.
Gengming Huang et al.
Introduction and hypothesis: Nuclear atypia with features of multi nuclei have been detected in human melanoma specimens. We found that the K type human endogenous retroviral element (HERV K) is expressed in such cells. S...