Antisense oligonucleotides directed against insulin-like growth factor-II messenger ribonucleic acids delay the progress of rat hepatocarcinogenesis [0.03%]
针对胰岛素样生长因子Ⅱ信使核糖核酸的反义寡核苷酸可延缓大鼠肝癌的发生发展过程
Miltu Kumar Ghosh,Falguni Patra,Shampa Ghosh et al.
Miltu Kumar Ghosh et al.
Background: Hepatocellular carcinoma (HCC) is a multistep complex process, caused by many of genetic alteration. Insulin-like growth factors and their receptor have been widely implicated to HCC. Insulin-like growth facto...
BRAF and beyond: Tailoring strategies for the individual melanoma patient [0.03%]
BRAF及其他：量体裁衣治疗黑色素瘤患者
Anthony Jarkowski rd,Nikhil I Khushalani
Anthony Jarkowski rd
Until recently, options for therapy in metastatic melanoma were limited. The understanding of immune check-point blockade and the discovery of molecular pathways involving driver mutations like BRAF has transformed the therapeutic landscape...
Thanyanan Reungwetwattana,Grace Kho Dy
Thanyanan Reungwetwattana
The iterative discovery in various malignancies during the past decades that a number of aberrant tumorigenic processes and signal transduction pathways are mediated by "druggable" protein kinases has led to a revolutionary change in drug d...
Peng Jiang,Wenjing Du,Xiaolu Yang
Peng Jiang
The tumor suppressor p53 plays a pre-eminent role in protecting against cancer, through its ability to sense various stresses and in turn invoke anti-proliferative and repair responses. Emerging evidence suggest that p53 is both a central s...
O-6-methylguanine-deoxyribonucleic acid methyltransferase methylation enhances response to temozolomide treatment in esophageal cancer [0.03%]
O-6-甲基鸟嘌呤脱氧核糖核酸甲基转移酶甲基化增强食管癌患者替莫唑胺治疗的疗效
Rifat Hasina,Mosmi Surati,Ichiro Kawada et al.
Rifat Hasina et al.
Background: World-wide, esophageal cancer is a growing epidemic and patients frequently present with advanced disease that is surgically inoperable. Hence, chemotherapy is the predominate treatment. Cytotoxic platinum com...
Sneha Sundaram,Amy R Johnson,Liza Makowski
Sneha Sundaram
Historically, cancer research has focused on identifying mutations or amplification of genes within the tumor, which informed the development of targeted therapies against affected pathways. This work often considers tumor cells in isolatio...
Intersection of Smoking, Human immunodeficiency virus/acquired immunodeficiency syndrome and Cancer: Proceedings of the 8(th) Annual Texas Conference on Health Disparities [0.03%]
吸烟、人类免疫缺陷病毒/获得性免疫缺陷综合征和癌症的交汇点：第八届德克萨斯健康差异大会会议纪要
Smrithi Rajendiran,Meghana V Kashyap,Jamboor K Vishwanatha
Smrithi Rajendiran
The Texas Center for Health Disparities, a National Institute on Minority Health and Health Disparities Center of Excellence, presents an annual conference to discuss prevention, awareness education and ongoing research about health dispari...
Michael A Reid,Mei Kong
Michael A Reid
Increased nutrient uptake and usage is a hallmark of many human malignancies. During the course of tumorigenesis, cancer cells often outstrip their local nutrient supply leading to periods of nutrient deprivation. Interestingly, cancer cell...
Unravelling the connection between metabolism and tumorigenesis through studies of the liver kinase B1 tumour suppressor [0.03%]
通过肝脏激酶B1肿瘤抑制因子研究解开代谢与肿瘤发生之间联系的秘密
David B Shackelford
David B Shackelford
The liver kinase B1 (LKB1) tumour suppressor functions as a master regulator of growth, metabolism and survival in cells, which is frequently mutated in sporadic human non-small cell lung and cervical cancers. LKB1 functions as a key upstre...
Restoration of the methylation status of hypermethylated gene promoters by microRNA-29b in human breast cancer: A novel epigenetic therapeutic approach [0.03%]
microRNA-29b通过作用于人乳腺癌中高甲基化基因的启动子来恢复其甲基化状态：一种新的表观遗传学治疗方法
Athena Starlard-Davenport,Kristi Kutanzi,Volodymyr Tryndyak et al.
Athena Starlard-Davenport et al.
It is well established that transcriptional silencing of critical tumor-suppressor genes by DNA methylation is a fundamental component in the initiation of breast cancer. However, the involvement of microRNAs (miRNAs) in restoring abnormal ...