A novel cancer syndrome caused by KCNQ1-deficiency in the golden Syrian hamster [0.03%]
由KCNQ1缺陷引起的金仓鼠癌症新综合征
Rong Li,Jinxin Miao,Alexandru-Flaviu Tabaran et al.
Rong Li et al.
Background: The golden Syrian hamster is an emerging model organism. To optimize its use, our group has made the first genetically engineered hamsters. One of the first genes that we investigated is KCNQ1 which encodes fo...
Bhairavi N Vajaria,Kinjal A Patel,Prabhudas S Patel
Bhairavi N Vajaria
Background: Carcinogenesis, a multistep process involves sequential changes during neoplastic transformation. The various hallmarks of cancer aid in cell survival, proliferation, and dissemination. Aberrant glycosylation,...
A case-control study on the association of abdominal obesity and hypercholesterolemia with the risk of colorectal cancer [0.03%]
腹部肥胖和高胆固醇血症与大肠癌发病风险的病例对照研究
Vaidehi Ulaganathan,Mirnalini Kandiah,Zalilah Mohd Shariff
Vaidehi Ulaganathan
Background: Obesity has frequently been associated with the dyslipidemic state and with the risk of various chronic diseases. Objective: ...
Genetic inhibition of autophagy in a transgenic mouse model of anal cancer [0.03%]
自噬小鼠肛癌转基因模型遗传抑制研究
Brooks L Rademacher,Louise M Meske,Kristina A Matkowskyj et al.
Brooks L Rademacher et al.
Background: The dynamic role of autophagy in cancer development is a topic of considerable research and debate. Previously published studies have shown that anal cancer development can be promoted or prevented with the ph...
Oncogenic and tumor suppressive roles of special AT-rich sequence-binding protein [0.03%]
特殊富AT序列结合蛋白的致癌和抑癌作用
Qiao Yi Chen,Max Costa
Qiao Yi Chen
In recent years, research efforts have been centered on the functional roles of special AT-rich sequence-binding protein (SATB2) in cancer development. Existing studies differ in the types of tumor tissues and cell lines used, resulting in ...
Evidence-based approaches to reduce cancer health disparities: Discover, develop, deliver, and disseminate [0.03%]
基于证据的方法来减少癌症健康差异：发现、发展、交付和传播
Priyanka P Desai,Jana B Lampe,Sulaimon A Bakre et al.
Priyanka P Desai et al.
The Texas Center for Health Disparities (TCHD) at the University of North Texas Health Science Center is a National Institute on Minority Health and Health Disparities-funded, specialized center of excellence for health disparities. TCHD or...
The impact of gender, race, socioeconomic status, and treatment on outcomes in esophageal cancer: A population-based analysis [0.03%]
性别、种族、社会经济状态以及治疗对食管癌预后影响的流行病学研究
Phu N Tran,Thomas H Taylor,Samuel J Klempner et al.
Phu N Tran et al.
Background: African Americans and Hispanics are reported to have higher mortality from esophageal cancer (EC) than Caucasians. In this study, we analyzed the independent effects of race, gender, treatment, and socioeconom...
Role of matrix metalloproteinase 13 gene expression in the evaluation of radiation response in oral squamous cell carcinoma [0.03%]
基质金属蛋白酶13基因表达在评估口腔鳞癌放射反应中的作用
Shankar Sharan Singh,Madan Lal Brahma Bhatt,Vandana Singh Kushwaha et al.
Shankar Sharan Singh et al.
Background: Matrix Metalloproteinase 13 (MMP13) is a member of collagenase family and it is involved in the degradation of extracellular matrix and basement membrane protein. It is thought to be associated with tumor inva...
Review of hepatocellular carcinoma: Epidemiology, etiology, and carcinogenesis [0.03%]
肝细胞癌的回顾：流行病学、病因和致癌机制
Yezaz Ahmed Ghouri,Idrees Mian,Julie H Rowe
Yezaz Ahmed Ghouri
Since the 1970s, the epidemic of hepatocellular carcinoma (HCC) has spread beyond the Eastern Asian predominance and has been increasing in Northern hemisphere, especially in the United States (US) and Western Europe. It occurs more commonl...
The well-accepted notion that gene amplification contributes to increased expression still remains, after all these years, a reasonable but unproven assumption [0.03%]
基因放大有助于提高表达量这一广为接受的观点时至今日仍然是一个合理的但未被证明的假设
Yuping Jia,Lichan Chen,Qingwen Jia et al.
Yuping Jia et al.
"Gene amplification causes overexpression" is a longstanding and well-accepted concept in cancer genetics. However, raking the whole literature, we find only statistical analyses showing a positive correlation between gene copy number and e...