Pharmacokinetic monitoring of busulfan in pediatric patients undergoing hematopoietic cell transplantation: Comparison of non-compartmental and compartmental analysis [0.03%]
布硫酸盐在造血细胞移植儿科患者药代动力学监测：非隔室分析与隔室分析的比较
Sandra García-Contreras,María Remedios Marqués-Miñana,Carolina Fuentes-Socorro et al.
Sandra García-Contreras et al.
IntroductionPharmacokinetic monitoring of busulfan allows individualized dosing in patients, which is essential due to its high interindividual variability and narrow therapeutic range. Non-compartmental and compartmental methods are used i...
Effectiveness and safety of first-line therapies, dual immunotherapy versus immunotherapy plus targeted therapy in advanced renal cell carcinoma: A systematic review and meta-analysis [0.03%]
一线免疫联合治疗对比单药治疗晚期肾细胞癌的疗效和安全性系统评价和meta分析
Avinash Khadela,Vaishnavi Patel,Beema T Yoosuf et al.
Avinash Khadela et al.
IntroductionThe preferred first-line regimen in advanced renal cell carcinoma (aRCC) remains uncertain, because rapid evolution of immunotherapy-based combination regimens quickly outdates the existing evidence. Current strategies for synth...
Impact of a pharmacist-led breast cancer clinic on oncology consultant workload and patient experience in a UK cancer centre [0.03%]
英国癌症治疗中心药剂师主导的乳腺癌诊所对肿瘤科医生工作量和患者体验的影响
Mr Michal Sladkowski
Mr Michal Sladkowski
PurposeUK oncology services face increasing demand alongside workforce constraints. This study evaluated the impact of a pharmacist-led breast cancer clinic on consultant workload and clinic utilisation in a UK district general hospital.Met...
Methodological considerations in a real-world study of first-line nivolumab plus ipilimumab for metastatic renal cell carcinoma [0.03%]
一线纳武利尤单抗联合伊匹木肽治疗转移性肾细胞癌的真实世界研究方法学考虑因素
Saptanil Das,Archana Dhyani,Rajnish Kumar et al.
Saptanil Das et al.
Lenvatinib use across multiple cancer types: A single-centre evaluation of dosing patterns, tolerability and opportunities for dose optimisation [0.03%]
仑伐替尼在多种癌症类型中的应用：单中心剂量模式、耐受性和剂量优化机会的评估
Jin Quan Eugene Tan,Natansh D Modi,Ramin Hassankhani et al.
Jin Quan Eugene Tan et al.
PurposeLenvatinib is an oral multi-kinase inhibitor prescribed in renal cell carcinoma (RCC), endometrial cancer (EC), hepatocellular carcinoma (HCC), and radioactive iodine-refractory differentiated thyroid cancer (DTC). Lenvatinib is poor...
Optimizing glycemic control in oncology patients with diabetes mellitus [0.03%]
糖尿病患者的血糖控制优化措施在肿瘤学中的应用
S Anandkumar,P Shobana,B Tharun et al.
S Anandkumar et al.
BackgroundCo-morbidity cancer and diabetes mellitus is a complex clinical issue due to the fact that cancer treatments, corticosteroid use, and polypharmacy can greatly interfere with glycemic control and predispose patients to the risk of ...
Remote collection of patient-reported quality of life outcomes via text messaging in cancer patients receiving oral anti-cancer therapy [0.03%]
利用手机短信远程收集癌症患者口服抗肿瘤药物治疗期间的功能状况及生活治疗相关数据
Sakib T Haque,Byung S Park,Joshua Choung et al.
Sakib T Haque et al.
PurposePatient-reported outcome measures (PROMs) are valuable tools for capturing how oral chemotherapy affects patients' quality of life (QOL), yet their integration into routine clinical practice remains limited. This study aimed to evalu...
Pharmacology-Guided venetoclax dose reduction with azacitidine in older or unfit acute myeloid leukemia: A North African experience from a Moroccan single-center cohort and exploratory hospital cost-effectiveness analysis [0.03%]
基于药理学的维奈克拉与阿扎胞苷联合治疗老年或合并症急性髓系白血病减剂量方案：来自摩洛哥单中心队列的北非用药经验及探索性医院成本效益分析
Baztami Youssef,Ilham Jebrane,Mohamed Amine Aznag et al.
Baztami Youssef et al.
IntroductionAzacitidine-venetoclax has improved outcomes in older or intensive chemotherapy-ineligible acute myeloid leukemia (AML) patients. However, real-world experience and pharmacoeconomic evidence remain scarce in resource-limited set...
Structural and thermal stability assessment of repackaged bevacizumab using RT-PCR-based differential scanning fluorimetry and intrinsic fluorescence spectroscopy [0.03%]
基于RT-PCR的差示扫描荧光法和固有荧光光谱法评估重构贝伐单抗的二级结构及热稳定性
Ludovica Palladino,Loredana Paglia,Giorgia Meschiari et al.
Ludovica Palladino et al.
IntroductionBevacizumab is a humanized monoclonal anti-VEGF antibody widely used in oncology and ophthalmology for the treatment of age-related macular degeneration and diabetic macular edema. Its intravitreal administration requires galeni...