Inference about binocular sensitivity and specificity of screening tests for paired organs [0.03%]
关于配对器官筛查试验的双眼敏感性与特异性的推断
Tsung-Shan Tsou,Wei-Cheng Hsiao
Tsung-Shan Tsou
Recently Perera et al. introduced two new binocular accuracy measures to evaluate diagnostic tests for paired organs. They adopted the Gaussian copula model to account for correlation between fellow eyes. As the measures are functions of se...
Clustered allocation as a way of understanding historical controls: Components of variation and regulatory considerations [0.03%]
聚类分配作为一种理解历史对照的方法：变异成分及监管考量
Olivier Collignon,Anna Schritz,Stephen J Senn et al.
Olivier Collignon et al.
There has been increasing interest in recent years in the possibility of increasing the efficiency of clinical trials by using historical controls. There has been a general recognition that in replacing concurrent by historical controls, th...
Two-level approaches to missing data in longitudinal trials with daily patient-reported outcomes [0.03%]
纵向试验中处理每日患者报告结果缺失数据的两级方法
Man Jin,Dai Feng,Guanghan Liu et al.
Man Jin et al.
In longitudinal clinical trials with daily patient-reported outcomes, the analysis endpoints are often defined as the averaged daily diary outcomes in a treatment cycle (such as a month or a week). Conventional methods often deal with missi...
Influence function-based empirical likelihood for inference of quantile medical costs with censored data [0.03%]
基于影响函数的实证似然方法在医学费用分位数推断中的应用研究
Jenny Jeyarajah,Guanhao Wei,Gengsheng Qin
Jenny Jeyarajah
In this paper, we propose empirical likelihood methods based on influence function and Jackknife techniques to construct confidence intervals for quantile medical costs with censored data. We show that the influence function-based empirical...
Toon Braeye
Toon Braeye
Time-stratified case-crossover design applied with conditional logistic regression is not free from overlap bias [0.03%]
条件逻辑回归下的时间分层病例交叉设计并非没有重叠偏倚
Xiaoming Wang,Sukun Wang,Warren Kindzierski
Xiaoming Wang
Group sequential design for time-to-event data using the concept of proportional time [0.03%]
基于时间比例概念的生存数据序贯设计方法研究
Milind A Phadnis,Matthew S Mayo
Milind A Phadnis
Sequential monitoring of efficacy and safety is an important part of clinical trials. A Group Sequential design allows researchers to perform interim monitoring after groups of patients have completed the study. Statistical literature is we...
Sample size considerations for comparing dynamic treatment regimens in a sequential multiple-assignment randomized trial with a continuous longitudinal outcome [0.03%]
序贯多分组随机临床试验中比较动态治疗方案的样本量考虑因素——连续型纵向结局指标的情形
Nicholas J Seewald,Kelley M Kidwell,Inbal Nahum-Shani et al.
Nicholas J Seewald et al.
Clinicians and researchers alike are increasingly interested in how best to personalize interventions. A dynamic treatment regimen is a sequence of prespecified decision rules which can be used to guide the delivery of a sequence of treatme...
Propensity score matching for treatment delay effects with observational survival data [0.03%]
利用观察性生存数据进行治疗延迟效应的倾向值匹配分析
Erinn M Hade,Giovanni Nattino,Heather A Frey et al.
Erinn M Hade et al.
In observational studies with a survival outcome, treatment initiation may be time dependent, which is likely to be affected by both time-invariant and time-varying covariates. In situations where the treatment is necessary for the study po...
On the use of the modified power series family of distributions in a cure rate model context [0.03%]
关于在一个治愈率模型环境中使用修改后的幂级数分布族的研究
Diego I Gallardo,Yolanda M Gómez,Héctor W Gómez et al.
Diego I Gallardo et al.
In this paper, we propose a generalization of the power series cure rate model for the number of competing causes related to the occurrence of the event of interest. The model includes distributions not yet used in the cure rate models cont...