A multinomial quadrivariate D-vine copula mixed model for meta-analysis of diagnostic studies in the presence of non-evaluable subjects [0.03%]
考虑非评价受试者的诊断研究Meta分析的多项式四变量Dvinecopula混合模型
Aristidis K Nikoloulopoulos
Aristidis K Nikoloulopoulos
Diagnostic test accuracy studies observe the result of a gold standard procedure that defines the presence or absence of a disease and the result of a diagnostic test. They typically report the number of true positives, false positives, tru...
Sample size calculation and re-estimation based on the prevalence in a single-arm confirmatory diagnostic accuracy study [0.03%]
基于单一臂确证性诊断准确性研究中患病率的样本量计算和再估计
Maria Stark,Antonia Zapf
Maria Stark
Introduction: In a confirmatory diagnostic accuracy study, sensitivity and specificity are considered as co-primary endpoints. For the sample size calculation, the prevalence of the target population must be taken into ac...
Clustering clinical and health care processes using a novel measure of dissimilarity for variable-length sequences of ordinal states [0.03%]
一种新型异质性度量在长度可变的序数状态序列的聚类中的应用——基于临床和医疗过程数据的分析研究
Hannah Johns,John Hearne,Julie Bernhardt et al.
Hannah Johns et al.
Clinical and health care processes are often summarised through sequences of ordinal data describing patient's state over time. Identifying patterns in these sequences can provide valuable insights into patient progression trajectories for ...
Joshua N Sampson,Mitchell H Gail
Joshua N Sampson
We provide methods to estimate the confidence interval for the difference between two relative risks. Letting p0, p1, and p2 be the probabilities of an event in three groups (i.e. control, treatment 1, treatment 2), our methods estimate a c...
Estimating the sample mean and standard deviation from commonly reported quantiles in meta-analysis [0.03%]
利用元分析中常用的分位数估计样本均值和标准差
Sean McGrath,XiaoFei Zhao,Russell Steele et al.
Sean McGrath et al.
Researchers increasingly use meta-analysis to synthesize the results of several studies in order to estimate a common effect. When the outcome variable is continuous, standard meta-analytic approaches assume that the primary studies report ...
Lifeng Lin
Lifeng Lin
Publication bias frequently appears in meta-analyses when the included studies' results (e.g., p-values) influence the studies' publication processes. Some unfavorable studies may be suppressed from publication, so the meta-analytic results...
Semiparametric integrative interaction analysis for non-small-cell lung cancer [0.03%]
非小细胞肺癌的半参数综合相互作用分析方法研究
Yang Li,Fan Wang,Rong Li et al.
Yang Li et al.
In genomic analysis, it is significant though challenging to identify markers associated with cancer outcomes or phenotypes. Based on the biological mechanisms of cancers and the characteristics of datasets, we propose a novel integrative i...
Modelling the patient accrual with truncated Gaussian mixture distribution for the accurate estimation of sample size in survival trials [0.03%]
基于生存试验中样本量精确估计的截断型高斯混合分布患者纳入模型化研究
Haixia Hu,Ling Wang,Chen Li et al.
Haixia Hu et al.
In survival trials with fixed trial length, the patient accrual rate has a significant impact on the sample size estimation or equivalently, on the power of trials. A larger sample size is required for the staggered patient entry. During en...
Accurate confidence intervals for proportion in studies with clustered binary outcome [0.03%]
具有聚类二元结果研究中的精确比例置信区间
Guogen Shan
Guogen Shan
Clustered binary data are commonly encountered in many medical research studies with several binary outcomes from each cluster. Asymptotic methods are traditionally used for confidence interval calculations. However, these intervals often h...
Optimized multiple testing procedures for nested sub-populations based on a continuous biomarker [0.03%]
基于连续生物标志物的嵌套亚群的优化多重检验方法
Alexandra Christine Graf,Dominic Magirr,Alex Dmitrienko et al.
Alexandra Christine Graf et al.
An important step in the development of targeted therapies is the identification and confirmation of sub-populations where the treatment has a positive treatment effect compared to a control. These sub-populations are often based on continu...