The blocking effect of the glycoprotein IIb/IIIa receptor in the mouse model of asthma [0.03%]
甘丙糖蛋白IIb/IIIa受体在哮喘小鼠模型中的抑制作用
Seo-Hee Kim,Hoang Kim Tu Trinh,Hae-Sim Park et al.
Seo-Hee Kim et al.
Background: It is apparent that the interaction between platelets and eosinophils plays a critical role in the activation of allergic inflammation. We investigated whether blocking of the glycoprotein (GP) IIb/IIIa recept...
Personalized medicine and allergen immunotherapy: the beginning of a new era? [0.03%]
个性化医学与过敏免疫治疗：一个新时代的开始？
Cristoforo Incorvaia,Erminia Ridolo,Diego Bagnasco et al.
Cristoforo Incorvaia et al.
The concept of personalized medicine as a diagnostic and therapeutic approach tailored to the medical needs of each patient is currently revolutionizing all fields of medicine and in particular allergology. Allergen immunotherapy (AIT) meet...
Dupilumab elicits a favorable response in type-2 inflammatory comorbidities of severe atopic dermatitis [0.03%]
杜普利尤单抗改善重度特应性皮炎伴发2型炎症共病症状
Eustachio Nettis,Lucia Masciopinto,Elisabetta Di Leo et al.
Eustachio Nettis et al.
Background: This case is the first report describing rapid, successful treatment of severe atopic dermatitis (AD) and comorbid type-2 inflammatory diseases in the same patient, with dupilumab treatment, with no side-effec...
Eleonora Di Salvo,Alessandro Allegra,Marco Casciaro et al.
Eleonora Di Salvo et al.
Pruritus is one of the most common symptoms experienced by neoplastic patients. The pathogenesis of neoplastic itch is complex and multifactorial and could be due to an unbalanced production of humoral mediators by altered immune effector c...
Marcello Cottini,Anita Licini,Carlo Lombardi et al.
Marcello Cottini et al.
Asthma is a common chronic condition, affecting approximately 339 million people worldwide. The main goal of the current asthma treatment guidelines is to achieve clinical control, encompassing both the patient symptoms and limitations and ...
Significant association between Taq1 gene polymorphism in vitamin D receptor and chronic spontaneous urticaria in the Northeast of Iran [0.03%]
维A受体Taq1基因多态性与伊朗东北地区慢性自发性荨麻疹的关联分析
Maryam Khoshkhui,Farzaneh Iravani,Farahzad Jabbari-Azad et al.
Maryam Khoshkhui et al.
Objective: Chronic spontaneous urticaria (CSU) is defined as urticaria with an unknown etiology which persists for more than 6 weeks. CSU is an uncomfortable cutaneous condition that occurs due to an immune-mediated infla...
Defining type 2 asthma and patients eligible for dupilumab in Italy: a biomarker-based analysis [0.03%]
基于生物标志物的分析定义意大利2型哮喘患者及杜匹卢单抗适用人群
Giorgio Walter Canonica,Francesco Blasi,Nunzio Crimi et al.
Giorgio Walter Canonica et al.
Background: Asthma is a chronic disease characterized by airway hyperresponsiveness, inflammation and mucus production. In Type 2 asthma, two phenotypic components are often co-expressed (eosinophilic and allergic). Eleva...
H2-antagonist in IgE-mediated type I hypersensitivity reactions: what literature says so far? [0.03%]
H2抗原在IgE介导的Ⅰ型变态反应中作用的文献回顾
Matteo Borro,Simone Negrini,Andrew Long et al.
Matteo Borro et al.
Histamine is a monoamine synthesized from the amino acid histidine that is well-known for its role in IgE-mediated anaphylaxis but has shown pleiotropic effects on the immune system, especially in order to promote inflammatory responses. H1...
Hereditary angioedema due to C1 inhibitor deficiency in Belarus: epidemiology, access to diagnosis and seven novel mutations in SERPING1 gene [0.03%]
白俄罗斯补体C1抑制剂缺乏引起的遗传性血管水肿的流行病学、诊疗现状及SERPING1基因突变分析
Irina Guryanova,Chiara Suffritti,Debora Parolin et al.
Irina Guryanova et al.
Background: Hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE) is a rare disease. Few states in developing countries have an adequate management of HAE, but none of them belongs to the former USSR area. Thi...
Tropomyosin in mugwort cross-reacts to house dust mite, eliciting non-Th2 response in allergic rhinitis patients sensitized to house dust mite [0.03%]
艾蒿肌动蛋白与尘螨交叉反应并激活非Th2型过敏性鼻炎患者的免疫反应
Su Duan,Limin Zhao,Yuling Zhang et al.
Su Duan et al.
Background: Mugwort and house dust mite (HDM) are two of the most common inhalant allergens in Asia, however, whether mugwort affects polysensitized HDM+ allergic rhinitis (AR) patients has not been elucidated. ...