T regulatory cells: an overview and intervention techniques to modulate allergy outcome [0.03%]
调节性T细胞：概览及干预技术以调控过敏反应
Subhadra Nandakumar,Christopher Wt Miller,Uday Kumaraguru
Subhadra Nandakumar
Dysregulated immune response results in inflammatory symptoms in the respiratory mucosa leading to asthma and allergy in susceptible individuals. The T helper type 2 (Th2) subsets are primarily involved in this disease process. Nevertheless...
Daniel A Ramirez Jr,Sami L Bahna
Daniel A Ramirez Jr
Though not widely recognized, food hypersensitivity by inhalation can cause major morbidity in affected individuals. The exposure is usually more obvious and often substantial in occupational environments but frequently occurs in non-occupa...
Mapping of IgE-binding regions on recombinant Cyn d 1, a major allergen from Bermuda Grass Pollen (BGP) [0.03%]
重组Cyn d 1（草地革缕草花粉主要过敏原）IgE结合表位的定位研究
Ruby Tiwari,Prem L Bhalla,Mohan B Singh
Ruby Tiwari
Background: Bermuda grass (Cynodon dactylon; subfamily Chloridoideae) is an important source of seasonal aeroallergens in warm tropical and sub-tropical areas worldwide. Improved approaches to diagnosis and therapy of all...
Matthew M Huckabee,R Stokes Peebles Jr
Matthew M Huckabee
Viruses are the predominant infectious cause of asthma exacerbations in the developed world. In addition, recent evidence strongly suggests that viral infections may also have a causal role in the development of childhood asthma. In this ar...
Should digestion assays be used to estimate persistence of potential allergens in tests for safety of novel food proteins? [0.03%]
消化试验能否用于估算新型食品蛋白过敏性试验中潜在过敏原的持久性？
Santiago Schnell,Rod A Herman
Santiago Schnell
Food allergies affect an estimated 3 to 4% of adults and up to 8% of children in developed western countries. Results from in vitro simulated gastric digestion studies with purified proteins are routinely used to assess the allergenic poten...
Anaphylaxis to husband's seminal plasma and treatment by local desensitization [0.03%]
对丈夫精液过敏的过敏性休克及局灶性脱敏治疗病例报告
Jaechun Lee,Sohyung Kim,Miok Kim et al.
Jaechun Lee et al.
Hypersensitivity to human seminal fluid is rare but can be life threatening. We report a case of IgE-mediated anaphylaxis to seminal plasma that was diagnosed by skin prick tests and successfully treated by local desensitization. A 32-year-...
Differential response of human basophil activation markers: a multi-parameter flow cytometry approach [0.03%]
人基质细胞激活标志物的差异反应：一种多参数流式细胞仪方法
Salvatore Chirumbolo,Antonio Vella,Riccardo Ortolani et al.
Salvatore Chirumbolo et al.
Background: Basophils are circulating cells involved in hypersensitivity reactions and allergy but many aspects of their activation, including the sensitivity to external triggering factors and the molecular aspects of ce...
Erick Forno,Andrew B Onderdonk,John McCracken et al.
Erick Forno et al.
Background: A modest number of prospective studies of the composition of the intestinal microbiota and eczema in early life have yielded conflicting results. ...
CpG Immunotherapy in Chenopodium album sensitized mice: The comparison of IFN-gamma, IL-10 and IgE responses in intranasal and subcutaneous administrations [0.03%]
CpG免疫疗法在 Chenopodium album 感染小鼠中的作用：与鼻内和皮下给药的IFN-γ、IL-10 和IgE反应的比较
Tahereh Mousavi,Nader Tajik,Maziar Moradi et al.
Tahereh Mousavi et al.
Background: Mucosal-based immunotherapy has been already used as an alternative form of allergen delivery. In asthma, the poor success rate of immune modulation could be a consequence of inadequate immune modulation in th...
Three dimensional structure directs T-cell epitope dominance associated with allergy [0.03%]
三维结构决定了与过敏相关的T细胞表位优势效应
Scott J Melton,Samuel J Landry
Scott J Melton
Background: CD4+ T-cell epitope immunodominance is not adequately explained by peptide selectivity in class II major histocompatibility proteins, but it has been correlated with adjacent segments of conformational flexibi...