Isolation of Tumour-Derived Extracellular Vesicles From the Plasma of Dogs Affected by Intracranial Tumours Showing Heterologous and Cross-Species Tropism: A Pilot Study [0.03%]
犬颅内肿瘤衍生的外源性囊泡的分离及其异嗜性和交叉物种感染性的研究：一项初步研究报告
Simona Vincenti,Alessandro Villa,Zemira de Mitri et al.
Simona Vincenti et al.
Canine and human brain tumours exhibit similar incidence rates and prognoses. Recent studies have demonstrated that extracellular vesicles derived from human patients (PDEVs) can be loaded with contrast agents and exhibit tumour tropism in ...
Vincristine Induced Adverse Effects in Lymphoma Bearing Dogs With Asymptomatic Neutropenia at the Time of Drug Administration [0.03%]
给药时无症状中性粒细胞减少的患淋巴瘤犬发生的长春新碱诱导的不良反应
Albert Thomas,Jessica Finlay,Elizabeth McKinnon et al.
Albert Thomas et al.
Vincristine sulphate, a microtubule inhibitor, is used extensively in veterinary oncology for treating lymphoma. Neutropenia during multiagent protocols is a common reason for treatment delay and reduced dose intensity. This study evaluated...
Targeting ATR Kinase as a Strategy for Canine Lymphoma and Leukaemia Treatment [0.03%]
靶向ATR激酶作为治疗犬淋巴瘤和白血病的策略
Marta Henklewska,Aleksandra Pawlak,Bożena Obmińska-Mrukowicz
Marta Henklewska
Ataxia telangiectasia and Rad3-related (ATR) kinase is one of the main regulators of cell response to DNA damage and replication stress. Effectiveness of ATR targeting in human cancers has been confirmed in preclinical studies and ATR inhib...
A Retrospective Study Evaluating the Outcomes of Conventionally Fractionated Radiation Therapy as a Treatment for Infiltrative Lipomas in Twenty-One Dogs [0.03%]
回顾性研究评估常规分割放射治疗21只患浸润性脂肪瘤犬的效果
Adam Hauser,Lily Thorsen,Mary-Keara Boss et al.
Adam Hauser et al.
Infiltrative lipomas represent a subcategorisation of rarer, potentially more aggressive, lipoma-related neoplasms. Twenty-one dogs treated with conventionally fractionated radiotherapy (CFRT) for infiltrative lipomas were included in this ...
Comparison of Fine-Needle Aspiration and Core Needle Biopsy for the Pre-Operative Diagnosis of Canine and Feline Mammary Gland Tumours [0.03%]
细针穿刺和空心针活检在犬猫乳腺肿瘤术前诊断中的比较研究
Thitida Pakdeesaneha,Katriya Chankow,Sirichai Techarungchaikul et al.
Thitida Pakdeesaneha et al.
Mammary gland tumours are common neoplasms that affect female dogs and cats. We compared the accuracy of pre-surgical fine-needle aspiration (FNA) and core needle biopsy (CNB) diagnosing feline (n = 64) and canine (n = 83) mammary gland tum...
Comparative Study
Veterinary and comparative oncology. 2024 Dec;22(4):566-573. DOI:10.1111/vco.13006 2024
Auranofin Suppresses the Growth of Canine Mammary Tumour Cells and Induces Apoptosis via the PI3K/AKT Pathway [0.03%]
金诺芬通过PI3K / AKT途径抑制犬乳腺肿瘤细胞的增殖并诱导凋亡
Zhaoyan Lin,Rong Chen,Jiao Wang et al.
Zhaoyan Lin et al.
Canine mammary gland tumour (CMT) is the most common spontaneous tumour in intact female dogs and often exhibits metastases. Auranofin (AF) is a gold complex used for treating rheumatism. The excellent anti-tumour ability of AF has been dem...
Histologic, Phenotypic, and Molecular Characterization of Feline Hodgkin-Like Lymphoma With Classical Reed-Sternberg Cells [0.03%]
具有经典里-斯特伯格细胞的猫霍奇金样淋巴瘤的组织病理学、表型和分子特征
Laura Marconato,Ilaria Maga,Selina Iussich et al.
Laura Marconato et al.
Hodgkin-like lymphoma (HLL) is a rare neoplasm in cats that shares characteristics with the human disease. The hallmark of HLL is the presence of Reed-Sternberg (RS) cells expressing CD30 and CD20. This study aimed to elucidate the clinicop...
Comprehensive Analysis of the Tumour Immune Microenvironment in Canine Urothelial Carcinoma Reveals Immunosuppressive Mechanisms Induced by the COX-Prostanoid Cascade [0.03%]
对犬膀胱尿路上皮癌肿瘤免疫微环境的综合分析揭示了COX-前列腺素级联诱导的免疫抑制机制
Shotaro Eto,Daiki Kato,Kohei Saeki et al.
Shotaro Eto et al.
A comprehensive understanding of the tumour immune microenvironment (TIME) is essential for advancing precision medicine and identifying potential therapeutic targets. This study focused on canine urothelial carcinoma (cUC) recognised for i...
Impact of 10% Dose Reductions and Duration of Treatment Delays in the Management of Chemotherapy-Induced Neutropenia in Dogs Treated With Common Chemotherapy Protocols: A Single-Centre Experience [0.03%]
单中心研究：化疗引起的中性粒细胞减少症管理中的10％剂量降低和治疗延迟持续时间对接受常见化疗方案的犬的影响
Suzanne Busser,Laura Blackwood,Constanza Pereira et al.
Suzanne Busser et al.
Neutropenia is a common chemotherapy-associated adverse event (AE) in dogs and a significant cause of decreased relative dose intensity. Dose reductions (DRs) and treatment delays (TDs) are frequently applied to decrease the risk of further...
Macrophage Colony Stimulating Factor (M-CSF) and Interleukin-34 (IL-34) Expression in Canine Osteosarcoma in the Context of the Tumour Immune Microenvironment [0.03%]
肿瘤免疫微环境中犬骨肉瘤中巨噬细胞集落刺激因子（M-CSF）和白介素-34（IL-34）的表达
Christopher J Robinson,Cambri E Moeller,Cally N Quick et al.
Christopher J Robinson et al.
Canine osteosarcoma (OSA) is a malignancy that has been shown to modulate the host immune system. Macrophage colony-stimulating factor (M-CSF; CSF1) and interleukin-34 (IL-34; IL34) are both ligands of colony stimulating factor 1 receptor (...