DNA vaccine elicits an efficient antitumor response by targeting the mutant Kras in a transgenic mouse lung cancer model [0.03%]
靶向突变型Kras基因的DNA疫苗在转基因小鼠肺癌模型中激发高效抗肿瘤免疫应答
T-Y Weng,M-C Yen,C-T Huang et al.
T-Y Weng et al.
Mutant Kras (V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) is observed in more than 20% of non-small-cell lung cancers; however, no effective Kras target therapy is available at present. The Kras DNA vaccine may represent as a novel...
A dual-reporter, diagnostic vector for prostate cancer detection and tumor imaging [0.03%]
一种用于检测和肿瘤成像的前列腺癌双报告基因诊断载体
J R Richter,M Mahoney,J M Warram et al.
J R Richter et al.
Detection of prostate-specific antigen (PSA) as a screening strategy for prostate cancer is limited by the inability of the PSA test to differentiate between malignant cancer and benign hyperplasia. Here, we report the use of a cancer-speci...
Differential targeting of feline photoreceptors by recombinant adeno-associated viral vectors: implications for preclinical gene therapy trials [0.03%]
重组腺相关病毒载体对猫视网膜感光细胞的差异性感染及其在临床基因治疗试验中的意义
A L Minella,F M Mowat,K L Willett et al.
A L Minella et al.
The cat is emerging as a promising large animal model for preclinical testing of retinal dystrophy therapies, for example, by gene therapy. However, there is a paucity of studies investigating viral vector gene transfer to the feline retina...
Long-term efficiency of mesenchymal stromal cell-mediated CD-MSC/5FC therapy in human melanoma xenograft model [0.03%]
人黑色素瘤异种移植模型中间质细胞介导的CD-MSC/5FC治疗的长期疗效研究
L Kucerova,S Skolekova,L Demkova et al.
L Kucerova et al.
Mesenchymal stromal cells (MSC) can be exploited as cellular delivery vehicles for the enzymes converting non-toxic prodrugs to toxic substances. Because of their inherent chemoresistance, they exert potent bystander and antitumor effect. H...
A dystrophic muscle broadens the contribution and activation of immune cells reacting to rAAV gene transfer [0.03%]
一种 dystrophic 肌肉扩大了对 rAAV 基因转移的免疫细胞的贡献和激活范围
M Ferrand,A Galy,F Boisgerault
M Ferrand
Recombinant adeno-associated viral vectors (rAAVs) are used for therapeutic gene transfer in skeletal muscle, but it is unclear if immune reactivity to gene transfer and persistence of transgene are affected by pathologic conditions such as...
AdLTR2EF1α-FGF2-mediated prevention of fractionated irradiation-induced salivary hypofunction in swine [0.03%]
ADLTR2和EF1α-FGF2介导的分次辐射诱导的猪唾液减少的预防作用研究
L Guo,R Gao,J Xu et al.
L Guo et al.
Patients frequently experience a loss of salivary function following irradiation (IR) for the treatment of an oral cavity and oropharyngeal cancer. Herein, we tested if transfer of fibroblast growth factor-2 (FGF2) cDNA could limit salivary...
Overexpression of superoxide dismutase 3 gene blocks high-fat diet-induced obesity, fatty liver and insulin resistance [0.03%]
超氧化物歧化酶3基因过表达抑制高脂饮食诱导的肥胖、脂肪肝和胰岛素抵抗
R Cui,M Gao,S Qu et al.
R Cui et al.
Oxidative stress has an important role in the development of obesity and obesity-associated metabolic disorders. As an endogenous antioxidant enzyme, superoxide dismutase 3 (SOD3) has the potential to affect diet-induced obesity and obesity...
Antitumor effects of baculovirus-infected dendritic cells against human pancreatic carcinoma [0.03%]
家蚕杆状病毒感染的树突状细胞的抗肿瘤效应作用于人类胰腺癌细胞中
A Fujihira,T Suzuki,M O Chang et al.
A Fujihira et al.
Recently, we showed that baculovirus (BV)-infected dendritic cells (DCs) (BV-DCs) induced antitumor immunity against established tumors in mice. These antitumor effects were CD8(+) T-cell and natural killer (NK) cell dependent but CD4(+) T-...
A Puppo,G Cesi,E Marrocco et al.
A Puppo et al.
Retinal gene therapy with adeno-associated viral (AAV) vectors is safe and effective in humans. However, the limited cargo capacity of AAV prevents their use for therapy of those inherited retinopathies (IRs) due to mutations in large (>5 k...
One-year follow-up of transgene expression by integrase-defective lentiviral vectors and their therapeutic potential in spinocerebellar ataxia model mice [0.03%]
整合酶缺陷型慢病毒载体的转基因表达一年随访及其在小鼠脊髓小脑共济失调模型中的治疗潜力
H Saida,Y Matsuzaki,K Takayama et al.
H Saida et al.
We examined integrase-defective lentiviral vectors (IDLVs) with a mutant (D64V) integrase in terms of their residual integration capability, the levels and duration of transgene expression and their therapeutic potential in comparison to wi...