Multiomics and deep learning dissect regulatory syntax in human development [0.03%]
多组学和深度学习解析人类发育的调控语法
Betty B Liu,Selin Jessa,Samuel H Kim et al.
Betty B Liu et al.
Transcription factors establish cell identity during development by binding regulatory DNA in a sequence-specific manner, often promoting local chromatin accessibility and regulating gene expression1. Mapping accessible chromatin offers cri...
Genetic predictors of GLP1 receptor agonist weight loss and side effects [0.03%]
GLP-1受体激动剂减重和不良反应的遗传预测因素
Qiaojuan Jane Su,James R Ashenhurst,Wanwan Xu et al.
Qiaojuan Jane Su et al.
The development of glucagon-like peptide 1 (GLP1) receptor agonists, including semaglutide and tirzepatide, has transformed the clinical management of overweight and obesity. However, substantial inter-person variability exists in both weig...
Population-scale repeat expansions elucidate disease risk and brain atrophy [0.03%]
基于人口的大规模重复扩张解析疾病风险和脑萎缩机制
Vijay Kumar Pounraja,Jae Hoon Sul,Joseph Herman et al.
Vijay Kumar Pounraja et al.
Pathogenic expansions of short tandem repeats (STRs) cause over 70 neurological diseases1-3. Here we performed a population-scale survey of pathogenic repeat expansions by analysing repeat length in 37 disease-associated STR loci in a diver...
Mummified early Permian reptile reveals ancient amniote breathing apparatus [0.03%]
早二叠世木乃伊化爬行动物揭示古老的羊膜动物呼吸装置
Robert R Reisz,Ethan D Mooney,Tea Maho et al.
Robert R Reisz et al.
Costal aspiration breathing was an evolutionary innovation that was fundamental to the conquest of the terrestrial realm by amniotes (mammals, reptiles, birds and their common ancestor)1-5. Extant amniotes use an integrated thoracic skeleto...
Jaclyn E Smith,Kevin J Wang,Erin M Kennedy et al.
Jaclyn E Smith et al.
Antigenic variation, using large genomic repertoires of antigen-encoding genes, allows pathogens to evade host antibody. Many pathogens, including the African trypanosome Trypanosoma brucei, extend their antigenic repertoire through genomic...
Heidi Ledford
Heidi Ledford
Jinru Zhang,Zhanao Liu
Jinru Zhang
Richa Chaudhary,Varun Chaudhary
Richa Chaudhary
Alfredo Vannacci
Alfredo Vannacci