What's behind China's historically high counts of corresponding authors? [0.03%]
中国通讯作者发文量创新高的背后原因是什么？
Dalmeet Singh Chawla
Dalmeet Singh Chawla
This mysterious lung disease affects millions of people - but a drug tested in mice shows promise [0.03%]
这种神秘的肺病影响数以百万计的人——但在小鼠身上进行试验的药物带来希望
Rachel Fieldhouse
Rachel Fieldhouse
Editorial Expression of Concern: Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo [0.03%]
对活细胞中通过诱导蛋白酶体降解鉴定DNA复制蛋白的蛋白质组功能鉴定的编辑部评论意见：编辑部表达关注
Masato Kanemaki,Alberto Sanchez-Diaz,Agnieszka Gambus et al.
Masato Kanemaki et al.
Cell-type-resolved genetic variation shapes inflammatory bowel disease risk [0.03%]
细胞类型特异性遗传变异影响炎症性肠病的发病风险
Tobi Alegbe,Bradley T Harris,Laura Fachal et al.
Tobi Alegbe et al.
Most genetic variants associated with complex diseases lie in non-coding regions1, complicating efforts to identify effector genes and relevant cell types. Here we map cis-expression quantitative trait loci (eQTLs) across 2.2 million single...
A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome [0.03%]
一种天然的depsipeptide类抗生素与细菌核糖体的E位点结合
Manpreet Kaur,Dmitrii Y Travin,Max J Berger et al.
Manpreet Kaur et al.
A key challenge in addressing the antibiotic resistance crisis is identifying new antimicrobial compounds1. Although natural products produced by fungi and bacteria, particularly actinomycetes, have been the source of most antibiotics disco...
Spermine is an endogenous iron chelator that inhibits ferroptosis [0.03%]
spermine是一种内源性铁螯合剂 可以抑制细胞ferroptosis现象
Man Li,Xuexin Yu,Shuqin Ouyang et al.
Man Li et al.
Ferroptosis is an iron-dependent form of cell death driven by lipid peroxidation1. Here we identify spermine-a polyamine derived from spermidine2-as an endogenous iron chelator that directly suppresses ferroptosis. Integrating metabolomics,...
Deguang Song,Brianna Duncan-Lowey,Varnica Khetrapal et al.
Deguang Song et al.
The microbiota produces thousands of potentially bioactive small molecules1-3. High-throughput bioactivity screens of in vitro commensal cultures have exposed microbiota metabolites that shape host physiology by activating diverse G-protein...
Ragini Bhargava,Megan A Mahlke,Tobias T Schmidt et al.
Ragini Bhargava et al.
Alternative lengthening of telomeres (ALT) is a specialized telomere extension mechanism associated with 5-10% of all cancers1. Although ALT has been linked to epigenetic dysregulation and genome instability, specific genomic and epigenetic...
D Nguyen,C Yero,H Szumila-Vance et al.
D Nguyen et al.
Atomic nuclei are intricate quantum systems in which nucleons (protons and neutrons) are held together by the strong nuclear force. At very short distances, nucleons can momentarily form high-momentum pairs-known as short-range-correlated p...