Rupert Faraway,Neve Costello Heaven,Holly Digby et al.
Rupert Faraway et al.
The concentration of proteins containing intrinsically disordered regions must be tightly controlled to maintain cellular homeostasis1,2. However, mechanisms for collective control of these proteins, which tend to localize to membraneless c...
Industry-compatible silicon spin-qubit unit cells exceeding 99% fidelity [0.03%]
适用于行业的硅自旋量子比特单元，保真度超过99%
Paul Steinacker,Nard Dumoulin Stuyck,Wee Han Lim et al.
Paul Steinacker et al.
Among the many types of qubit presently being investigated for a future quantum computer, silicon spin qubits with millions of qubits on a single chip are uniquely positioned to enable quantum computing. However, it has not been clear wheth...
Leonardo Gomes de Lima,Andrea Guarracino,Sergey Koren et al.
Leonardo Gomes de Lima et al.
Robertsonian chromosomes are a type of variant chromosome that is commonly found in nature. Present in 1 in 800 humans, these chromosomes can underlie infertility, trisomies and increased cancer incidence1-5. They have been recognized cytog...
Amir Bahat,Dusanka Milenkovic,Eileen Cors et al.
Amir Bahat et al.
Metabolic dysregulation can lead to inflammatory responses1,2. Imbalanced nucleotide synthesis triggers the release of mitochondrial DNA (mtDNA) to the cytosol and an innate immune response through cGAS-STING signalling3. However, how nucle...
Qiubo Zhang,Max C Gallant,Yi Chen et al.
Qiubo Zhang et al.
Kinetically trapping the high-temperature states through rapid cooling solidification is widely used for the synthesis of high-entropy alloys (HEAs), especially those with intrinsically immiscible elemental combinations1-4. However, strateg...
Yu Guo,Murukarthick Jayakodi,Axel Himmelbach et al.
Yu Guo et al.
Barley is one of the oldest cultivated crops, with a complex evolutionary and domestication history1. Previous studies have rejected the idea of a single origin and instead support a model of mosaic genomic ancestry2,3. With increasingly co...
Holliday junction-ZMM protein feedback enables meiotic crossover assurance [0.03%]
霍利迪连接-ZMM蛋白反馈可保障减数重组交叉型形成
Adrian Henggeler,Lucija Orlić,Daniel Velikov et al.
Adrian Henggeler et al.
Holliday junctions (HJs) are branched four-way DNA structures that link recombining chromosomes during double-strand break repair1. Despite posing a risk to chromosome segregation, HJs accumulate during meiotic prophase I as intermediates i...
Fangyuan Mao,Shan Jiang,Jun Liu et al.
Fangyuan Mao et al.
The evolution of a single-dentary-boned lower jaw and its secondary craniomandibular articulation between the dentary condyle and the squamosal glenoid has been regarded as a pivotal vertebrate innovation and defining mammalian trait1-7. He...
In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma [0.03%]
体内CRISPR筛选鉴定出多发性骨髓瘤中调节CAR-T细胞功能的修饰因子
Nelson H Knudsen,Giulia Escobar,Felix Korell et al.
Nelson H Knudsen et al.
Chimeric antigen receptor (CAR) T cells are highly effective in haematological malignancies1. However, progressive loss of CAR T cells contributes to relapse in many patients2-4. Here we performed in vivo loss-of-function CRISPR screens in ...
Eva Mittler,Alexandra L Tse,Pham-Tue-Hung Tran et al.
Eva Mittler et al.
Tick-borne encephalitis virus (TBEV) causes tick-borne encephalitis (TBE), a severe and sometimes life-threatening disease characterized by viral invasion of the central nervous system with symptoms of neuroinflammation1,2. As with other or...