Ryan V Raut,Zachary P Rosenthal,Xiaodan Wang et al.
Ryan V Raut et al.
Neural activity in awake organisms shows widespread, spatiotemporally diverse correlations with behavioural and physiological measurements1-4. We propose that this covariation reflects in part the structured, nonlinear dynamics of an underl...
Systematic discovery of CRISPR-boosted CAR T cell immunotherapies [0.03%]
利用CRISPR技术增强CAR-T细胞免疫疗法的系统性研究方法
Paul Datlinger,Eugenia V Pankevich,Cosmas D Arnold et al.
Paul Datlinger et al.
Chimeric antigen receptor (CAR) T cell therapy has shown remarkable success in treating blood cancers, but CAR T cell dysfunction remains a common cause of treatment failure1. Here we present CELLFIE, a CRISPR screening platform for enhanci...
Tailoring polymer electrolyte solvation for 600 Wh kg-1 lithium batteries [0.03%]
用于600 Wh kg-1锂金属电池的聚合物电解质溶剂化结构调控
Xue-Yan Huang,Chen-Zi Zhao,Wei-Jin Kong et al.
Xue-Yan Huang et al.
Polymer electrolytes paired with lithium-rich manganese-based layered oxide (LRMO) cathodes and anode-free cell design are considered one of the most promising high-energy-density and high-safety systems1-4. However, the unstable anode morp...
Protecting double Holliday junctions ensures crossing over during meiosis [0.03%]
保护双霍洛利节帮确保减数分裂时交换的进行
Shangming Tang,Sara Hariri,Regina Bohn et al.
Shangming Tang et al.
Chromosomal linkages formed through crossover recombination are essential for the accurate segregation of homologous chromosomes during meiosis1. The DNA events of recombination are linked to structural components of meiotic chromosomes2. I...
Design of facilitated dissociation enables timing of cytokine signalling [0.03%]
设计促进解离使细胞因子信号传导的定时成为可能
Adam J Broerman,Christoph Pollmann,Yang Zhao et al.
Adam J Broerman et al.
Protein design has focused on the design of ground states, ensuring that they are sufficiently low energy to be highly populated1. Designing the kinetics and dynamics of a system requires, in addition, the design of excited states that are ...
Low-overhead transversal fault tolerance for universal quantum computation [0.03%]
适用于通用量子计算的低开销穿越容错方案
Hengyun Zhou,Chen Zhao,Madelyn Cain et al.
Hengyun Zhou et al.
Fast, reliable logical operations are essential for realizing useful quantum computers1-3. By redundantly encoding logical qubits into many physical qubits and using syndrome measurements to detect and correct errors, we can achieve low log...
Proximal cooperative aerial manipulation with vertically stacked drones [0.03%]
垂直堆叠的无人机进行协同操作式航拍omanipulation
Huazi Cao,Jiahao Shen,Yin Zhang et al.
Huazi Cao et al.
Enabling vertical-stack proximal cooperation between multirotor flying robots can facilitate the execution of complex aerial manipulation tasks. However, vertical-stack proximal flight is commonly regarded as a dangerous condition that shou...
Sarah Cherkaoui,Christina S Turn,Yuan Yuan et al.
Sarah Cherkaoui et al.
Neuroblastoma is a highly lethal childhood tumour derived from differentiation-arrested neural crest cells1,2. Like all cancers, its growth is fuelled by metabolites obtained from either circulation or local biosynthesis3,4. Neuroblastomas ...
SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer [0.03%]
SPP1是维持胰腺癌间充质细胞命运所必需的
Huafu Li,Linxiang Lan,Hengxing Chen et al.
Huafu Li et al.
Elucidating the complex network of communication between tumour cells is central to understanding cell fate decisions and progression of pancreatic ductal adenocarcinoma (PDAC)1,2. We previously showed that constant suppression of BMP activ...
Samantha L Rumschlag,Brian Gallagher,Ryan Hill et al.
Samantha L Rumschlag et al.
Worldwide, freshwater systems contain more than 18,000 fish species1-3, which are critical to the functioning of these ecosystems4 and are vital cultural and economic resources to humans5-7; despite this value, fish biodiversity is at risk ...