Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools [0.03%]
利用互补计算工具解析一类以喹唑啉为基本框架的抗血吸虫药剂新家族的作用酶靶点
Victor Sebastian-Perez,Alfonso García-Rubia,Sayed H Seif El-Din et al.
Victor Sebastian-Perez et al.
A previous phenotypic screening campaign led to the identification of a quinazoline derivative with promising in vitro activity against Schistosoma mansoni. Follow-up studies of the antischistosomal potential of this candidate are presented...
Sulfocoumarins as dual inhibitors of human carbonic anhydrase isoforms IX/XII and of human thioredoxin reductase [0.03%]
硫香豆素作为人碳酐酶同工酶IX / XII和人硫氧还蛋白还原酶的双靶标抑制剂
Mikhail Krasavin,Raivis Žalubovskis,Aiga Grandāne et al.
Mikhail Krasavin et al.
The hypothesis that sulfocoumarin acting as inhibitors of human carbonic anhydrase (CA, EC 4.2.1.1) cancer-associated isoforms hCA IX and - hCA XII is being able to also inhibit thioredoxin reductase was verified and confirmed. The dual tar...
Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes [0.03%]
高效可逆的丁酰胆碱酯酶抑制剂类荧光探针的设计合成与发展研究
Stane Pajk,Damijan Knez,Urban Košak et al.
Stane Pajk et al.
Brain butyrylcholinesterase (BChE) is an attractive target for drugs designed for the treatment of Alzheimer's disease (AD) in its advanced stages. It also potentially represents a biomarker for progression of this disease. Based on the cry...
Synthesis and human carbonic anhydrase I, II, VA, and XII inhibition with novel amino acid-sulphonamide conjugates [0.03%]
新型氨基酸-磺酰胺缀合物的合成及其对人碳酐酶I、II、VA和XII的抑制作用
Hasan Küçükbay,Nesrin Buğday,F Zehra Küçükbay et al.
Hasan Küçükbay et al.
A series of amino acid-sulphonamide conjugates was prepared through benzotriazole mediated coupling reactions and characterised by 1H-NMR, 13C-NMR, MS, and FTIR spectroscopic techniques as well as elemental analysis. The carbonic anhydrase ...
Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators [0.03%]
异喹啉-5-карбальдохим作为乙酰胆碱酯酶和丁酰胆碱酯酶再活化剂的合成，体外筛选及分子对接研究
David Malinak,Rafael Dolezal,Vendula Hepnarova et al.
David Malinak et al.
The series of symmetrical and unsymmetrical isoquinolinium-5-carbaldoximes was designed and prepared for cholinesterase reactivation purposes. The novel compounds were evaluated for intrinsic acetylcholinesterase (AChE) or butyrylcholineste...
Synthesis and biological evaluation of novel (E)- N'-benzylidene hydrazides as novel c-Met inhibitors through fragment based virtual screening [0.03%]
基于片段的虚拟筛选发现新型(E)-N'-苯亚甲基肼类c-Met抑制剂及其生物活性研究
Jing-Wei Liang,Shi-Long Li,Shan Wang et al.
Jing-Wei Liang et al.
C-Met plays a crucial role in the development and progression of neoplastic disease. Type II c-Met inhibitors recognise the inactive DFG-out conformation of the kinase, result in better anti-tumour effects due to synergistic effect against ...
Novel CDKs inhibitors for the treatment of solid tumour by simultaneously regulating the cell cycle and transcription control [0.03%]
一种同时调节细胞周期和转录控制的新型CDK抑制剂用于实体瘤的治疗
Xin Wang,Kaiyuan Deng,Cheng Wang et al.
Xin Wang et al.
A novel series of cyclin-dependent kinases (CDKs) inhibitors, which play critical roles in the cell cycle control and regulation of cell transcription, were synthesised. A systematic study of enzymatic and cellular assays led to the identif...
Sulphonamides incorporating 1,3,5-triazine structural motifs show antioxidant, acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibitory profile [0.03%]
含三嗪基元的磺胺类衍生物的抗氧化及乙酰胆碱酯酶、丁酸胆碱酯酶和酪氨酸酶抑制活性研究
Nabih Lolak,Mehmet Boga,Muhammed Tuneg et al.
Nabih Lolak et al.
A series of 16 novel benzenesulfonamides incorporating 1,3,5-triazine moieties substituted with aromatic amines, dimethylamine, morpholine and piperidine were investigated. These compounds were assayed for antioxidant properties by using 1,...
Design, synthesis and cholinesterase inhibitory properties of new oxazole benzylamine derivatives [0.03%]
新型氧唑苯胺衍生物的设计、合成及乙酰胆碱酯酶抑制活性研究
Ivana Šagud,Nikolina Maček Hrvat,Ana Grgičević et al.
Ivana Šagud et al.
The enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are primary targets in attenuating the symptoms of neurodegenerative diseases. Their inhibition results in elevated concentrations of the neurotransmitter acetylcholin...
Design, synthesis, and antiprotozoal evaluation of new 2,4-bis[(substituted-aminomethyl)phenyl]quinoline, 1,3-bis[(substituted-aminomethyl)phenyl]isoquinoline and 2,4-bis[(substituted-aminomethyl)phenyl]quinazoline derivatives [0.03%]
新的2,4-双（取代氨甲基）苯基喹啉、1,3-双（取代氨甲基）苯基异喹啉和2,4-双（取代氨甲基）苯基噌啉衍生物的设计、合成及抗原生动物活性评价
Jean Guillon,Anita Cohen,Clotilde Boudot et al.
Jean Guillon et al.
A series of new 2,4-bis[(substituted-aminomethyl)phenyl]quinoline, 1,3-bis[(substituted-aminomethyl)phenyl]isoquinoline, and 2,4-bis[(substituted-aminomethyl)phenyl]quinazoline derivatives was designed, synthesised, and evaluated in vitro a...