Discovery of novel ATAD2 bromodomain inhibitors that trigger apoptosis and autophagy in breast cells by structure-based virtual screening [0.03%]
基于结构的虚拟筛选发现新型ATAD2溴结构域抑制剂可触发乳腺细胞凋亡和自噬
Dahong Yao,Jin Zhang,Jinhui Wang et al.
Dahong Yao et al.
ATAD2 has been reported to play an important role in the processes of numerous cancers and validated to be a potential therapeutic target. This work is to discover potent ATAD2 inhibitors and elucidate the underlying mechanisms in breast ca...
Synthesis, biological evaluation and molecular modelling of 2,4-disubstituted-5-(6-alkylpyridin-2-yl)-1 H-imidazoles as ALK5 inhibitors [0.03%]
作为ALK5抑制剂的2,4-取代-5-(6-烷基吡啶-2-基)-1H-咪唑的合成、生物评价及分子建模研究
Myoung-Soon Park,Hyun-Ju Park,Young Jae An et al.
Myoung-Soon Park et al.
A series of 2,4-disubstituted-5-(6-alkylpyridin-2-yl)-1H-imidazoles, 7a-c, 11a-h, and 16a-h has been synthesised and evaluated for their ALK5 inhibitory activity in an enzyme assay and in a cell-based luciferase reporter assay. Incorporatio...
Examination of sulfonamide-based inhibitors of MMP3 using the conditioned media of invasive glioma cells [0.03%]
利用侵袭性胶质瘤细胞的培养上清液检测磺胺类MMP3抑制剂
Alisha T Poole,Christopher A Sitko,Caitlin Le et al.
Alisha T Poole et al.
Glioblastoma multiforme (GBM) is the deadliest and the most common primary malignant brain tumour. The median survival for patients with GBM is around one year due to the nature of glioma cells to diffusely invade that make the complete sur...
Synthesis and characterisation of thiobarbituric acid enamine derivatives, and evaluation of their α-glucosidase inhibitory and anti-glycation activity [0.03%]
噻巴酸烯胺衍生物的合成、表征及其α-糖苷酶抑制和抗 glycation活性评价
M Ali,Assem Barakat,Ayman El-Faham et al.
M Ali et al.
A new series of thiobarbituric (thiopyrimidine trione) enamine derivatives and its analogues barbituric acid derivatives was synthesised, characterised, and screen for in vitro evaluation of α-glucosidase enzyme inhibition and anti-glycati...
Design, synthesis and antifungal activity of threoninamide carbamate derivatives via pharmacophore model [0.03%]
基于药效团模型的丝氨酰胺甲酸酯类化合物的设计、合成及抗真菌活性研究
Xiu-Jiang Du,Xing-Jie Peng,Rui-Qi Zhao et al.
Xiu-Jiang Du et al.
Thirty-six novel threoninamide carbamate derivatives were designed and synthesised using active fragment-based pharmacophore model. Antifungal activities of these compounds were tested against Oomycete fungi Phytophthora capsici in vitro an...
Combining carbonic anhydrase and thioredoxin reductase inhibitory motifs within a single molecule dramatically increases its cytotoxicity [0.03%]
在一个分子中结合碳酸酐酶和硫氧还蛋白还原酶抑制基序可显著增加其细胞毒性
Mikhail Krasavin,Tatiana Sharonova,Vladimir Sharoyko et al.
Mikhail Krasavin et al.
A hypothesis that simultaneous targeting cancer-related carbonic anhydrase hCA IX and hCA XII isoforms (whose overexpression is a cancer cell's defence mechanism against hypoxia) along with thioredoxin reductase (overexpressed in cancers as...
Mariantonia Logozzi,Davide Mizzoni,Rossella Di Raimo et al.
Mariantonia Logozzi et al.
Telomeres length and telomerase activity are currently considered aging molecular stigmata. Water is a major requirement for our body and water should be alkaline. Recent reports have shown that aging is related to a reduced water intake. W...
7-Acylamino-3H-1,2-benzoxathiepine 2,2-dioxides as new isoform-selective carbonic anhydrase IX and XII inhibitors [0.03%]
新的形式选择性碳酸酐酶IX和XII抑制剂：7-酰氨基-3H-1，2-苯并氧硫平2，2-二氧化物
Aleksandrs Pustenko,Alessio Nocentini,Anastasija Balašova et al.
Aleksandrs Pustenko et al.
A series of 3H-1,2-benzoxathiepine 2,2-dioxides incorporating 7-acylamino moieties were obtained by an original procedure starting from 5-nitrosalicylaldehyde, which was treated with propenylsulfonyl chloride followed by Wittig reaction of ...
Discovery of small molecule inhibitors of Leishmania braziliensis Hsp90 chaperone [0.03%]
莱什曼原虫HSP90分子抑制剂的发现
Fernanda A H Batista,Sérgio L Ramos Jr,Giusy Tassone et al.
Fernanda A H Batista et al.
Leishmaniasis is a neglected disease caused by the protozoa Leishmania ssp. Environmental differences found by the parasites in the vector and the host are translated into cellular stress, leading to the production of heat shock proteins (H...
Aspartic peptidase of Phialophora verrucosa as target of HIV peptidase inhibitors: blockage of its enzymatic activity and interference with fungal growth and macrophage interaction [0.03%]
表皮葡萄球菌天冬肽酶作为HIV肽酶抑制剂的作用靶点：其酶活性的阻断，以及对真菌生长和巨噬细胞相互作用的影响
Marcela Q Granato,Ingrid S Sousa,Thabatta L S A Rosa et al.
Marcela Q Granato et al.
Phialophora verrucosa causes several fungal human diseases, mainly chromoblastomycosis, which is extremely difficult to treat. Several studies have shown that human immunodeficiency virus peptidase inhibitors (HIV-PIs) are attractive candid...