Screening of ninety herbal products of commercial interest as potential ingredients for phytocosmetics [0.03%]
筛选出90种具有商业价值的草药产品作为潜在的植物化妆品原料
Mariacaterina Lianza,Manuela Mandrone,Ilaria Chiocchio et al.
Mariacaterina Lianza et al.
Elastase and tyrosinase are important targets both for cosmetics and for dermatological disorders. In this work, ninety herbal products were tested as inhibitors of these two enzymes. Eleven extracts resulted strongly active. Four out of th...
Biochemical and structural characterisation of a protozoan beta-carbonic anhydrase from Trichomonas vaginalis [0.03%]
阴道毛滴虫原生动物β-碳酸酐酶的生化及结构分析
Linda J Urbański,Anna Di Fiore,Latifeh Azizi et al.
Linda J Urbański et al.
We report the biochemical and structural characterisation of a beta-carbonic anhydrase (β-CA) from Trichomonas vaginalis, a unicellular parasite responsible for one of the world's leading sexually transmitted infections, trichomoniasis. CA...
Recent advances in modulators of circadian rhythms: an update and perspective [0.03%]
节律调节点最新研究进展：更新与展望
Shenzhen Huang,Xinwei Jiao,Dingli Lu et al.
Shenzhen Huang et al.
Circadian rhythm is a universal life phenomenon that plays an important role in maintaining the multiple physiological functions and regulating the adaptability to internal and external environments of flora and fauna. Circadian alignment i...
Prognostic value of CAIX expression in oral squamous cell carcinoma: a systematic review and meta-analysis [0.03%]
CAIX在口腔鳞癌中的预后价值：系统评价和Meta分析
Alejandro I Lorenzo-Pouso,Mercedes Gallas-Torreira,Mario Pérez-Sayáns et al.
Alejandro I Lorenzo-Pouso et al.
Carbonic anhydrase IX (CAIX) is a hypoxia-related protein considered as a predictor for oral squamous cell carcinoma (OSCC) biological behaviour. Nevertheless, this prognostic value is still yet to be validated. We aim to quantify prognosti...
Discovery of secondary sulphonamides as IDO1 inhibitors with potent antitumour effects in vivo [0.03%]
体内有效且具有抗肿瘤作用的IDO1抑制剂类磺胺衍生物的发现
Shushan Ge,Haiqing Zhong,Xuewei Ma et al.
Shushan Ge et al.
Indoleamine 2,3-dioxygenase 1 (IDO1) as a key rate-limiting enzyme in the kynurenine pathway of tryptophan metabolism plays an important role in tumour immune escape. Herein, a variety of secondary sulphonamides were synthesised and evaluat...
A nanobody-derived mimotope against VEGF inhibits cancer angiogenesis [0.03%]
一种抗VEGF纳米抗体衍生模拟表位抑制癌症血管生成
Elmira Karami,Jean-Marc Sabatier,Mahdi Behdani et al.
Elmira Karami et al.
Vascular Endothelial Growth Factor (VEGF) promotes angiogenesis in tumours of various cancers. Monoclonal antibodies and nanobodies are one of the potent agents in the treatment of cancer. Due to their high costs, researchers are considerin...
Discovery and antibacterial study of potential PPK1 inhibitors against uropathogenic E. coli [0.03%]
尿路致病性大肠杆菌PPK1潜在抑制剂的发现及抗菌研究
Liang Peng,Liting Zeng,Hongwei Jin et al.
Liang Peng et al.
Novel antibacterial agents are urgently needed to address the infections caused by multi-drug resistant bacteria. Urinary tract infections are common infectious diseases in clinical. Most of these infections are caused by drug-resistant uro...
Natural compounds as inhibitors of transthyretin amyloidosis and neuroprotective agents: analysis of structural data for future drug design [0.03%]
天然化合物作为转运蛋白淀粉样变性和神经保护剂抑制剂：结构数据的分析以用于未来的药物设计
Lidia Ciccone,Nicoló Tonali,Susanna Nencetti et al.
Lidia Ciccone et al.
Natural compounds, such as plant and fruit extracts have shown neuroprotective effect against neurodegenerative diseases. It has been reported that several natural compounds binding to transthyretin (TTR) can be useful in amyloidosis preven...
Carbonic anhydrase modulation of emotional memory. Implications for the treatment of cognitive disorders [0.03%]
碳酸酐酶调节情绪记忆及其对认知障碍治疗的意义
Patrizio Blandina,Gustavo Provensi,Maria Beatrice Passsani et al.
Patrizio Blandina et al.
Carbonic anhydrases (CAs, EC 4.2.1.1) are metalloenzymes which use CO2 as substrate, catalysing its interconversion to bicarbonate and a proton. In humans 15 CAs are expressed, 12 of which are catalytically active: the cytosolic CA I-III, V...
Synthesis of calix[4]azacrown substituted sulphonamides with antioxidant, acetylcholinesterase, butyrylcholinesterase, tyrosinase and carbonic anhydrase inhibitory action [0.03%]
一类具有抗氧化及胆碱酯酶、酪氨酸酶和碳酸酐酶抑制活性的杯[4]芳烃冠醚亚胺类化合物的合成
Mehmet Oguz,Erbay Kalay,Suleyman Akocak et al.
Mehmet Oguz et al.
A series of novel calix[4]azacrown substituted sulphonamide Schiff bases was synthesised by the reaction of calix[4]azacrown aldehydes with different substituted primary and secondary sulphonamides. The obtained novel compounds were investi...